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ADORA1-202 ,ADORA1 ,P30542
  • Uniprot Accession= P30542
  • Ensembl Transcript= ENST00000337894.9
  • Uniprot Name= ADORA1
  • Name= Adenosine receptor A1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 72
GO term GO name GO namespace GO def
GO:0001664 G protein-coupled receptor binding molecular_function Binding to a G protein-coupled receptor. [GOC:ceb, GOC:dph]
GO:0001883 purine nucleoside binding molecular_function Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. [GOC:hjd]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0031072 heat shock protein binding molecular_function Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw]
GO:0031683 G-protein beta/gamma-subunit complex binding molecular_function Binding to a complex of G-protein beta/gamma subunits. [GOC:nln, GOC:vw]
GO:0032795 heterotrimeric G-protein binding molecular_function Binding to a heterotrimeric G-protein. [GOC:nln]
GO:0046982 protein heterodimerization activity molecular_function Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
GO:0001659 temperature homeostasis biological_process A homeostatic process in which an organism modulates its internal body temperature. [GOC:jl]
GO:0001666 response to hypoxia biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
GO:0001973 G protein-coupled adenosine receptor signaling pathway biological_process The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. [GOC:dph]
GO:0002087 regulation of respiratory gaseous exchange by nervous system process biological_process A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. [GOC:dph, GOC:tb, PMID:12458206]
GO:0002674 negative regulation of acute inflammatory response biological_process Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. [GOC:add]
GO:0002686 negative regulation of leukocyte migration biological_process Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. [GOC:add]
GO:0002793 positive regulation of peptide secretion biological_process Any process that activates or increases the frequency, rate, or extent of peptide secretion. [GOC:add]
GO:0003084 positive regulation of systemic arterial blood pressure biological_process The process that increases the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]
GO:0003085 negative regulation of systemic arterial blood pressure biological_process The process that reduces the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]
GO:0003093 regulation of glomerular filtration biological_process Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. [GOC:mtg_cardio]
GO:0006612 protein targeting to membrane biological_process The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators]
GO:0006909 phagocytosis biological_process A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732]
GO:0006954 inflammatory response biological_process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
GO:0007165 signal transduction biological_process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway biological_process A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
GO:0007267 cell-cell signaling biological_process Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
GO:0007399 nervous system development biological_process The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
GO:0008285 negative regulation of cell population proliferation biological_process Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
GO:0010035 response to inorganic substance biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]
GO:0014050 negative regulation of glutamate secretion biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]
GO:0014074 response to purine-containing compound biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. [GOC:ef]
GO:0016042 lipid catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
GO:0032229 negative regulation of synaptic transmission, GABAergic biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]
GO:0032244 positive regulation of nucleoside transport biological_process Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
GO:0032900 negative regulation of neurotrophin production biological_process Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin. [GOC:mah]
GO:0035307 positive regulation of protein dephosphorylation biological_process Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. [GOC:bf]
GO:0042311 vasodilation biological_process An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. [GOC:pr, ISBN:0192800981]
GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep biological_process Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. [GOC:jl]
GO:0043066 negative regulation of apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0043268 positive regulation of potassium ion transport biological_process Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]
GO:0043410 positive regulation of MAPK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
GO:0046888 negative regulation of hormone secretion biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]
GO:0050890 cognition biological_process The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. [ISBN:0721619908]
GO:0050900 leukocyte migration biological_process The movement of a leukocyte within or between different tissues and organs of the body. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
GO:0050965 detection of temperature stimulus involved in sensory perception of pain biological_process The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
GO:0050995 negative regulation of lipid catabolic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]
GO:0050996 positive regulation of lipid catabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]
GO:0051930 regulation of sensory perception of pain biological_process Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. [GOC:ai]
GO:0051967 negative regulation of synaptic transmission, glutamatergic biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
GO:0055089 fatty acid homeostasis biological_process Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. [GOC:BHF, GOC:rl]
GO:0060079 excitatory postsynaptic potential biological_process A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
GO:0060292 long-term synaptic depression biological_process A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]
GO:0070254 mucus secretion biological_process The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. [GOC:add, ISBN:068340007X, ISBN:0721662544]
GO:0070256 negative regulation of mucus secretion biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]
GO:0070328 triglyceride homeostasis biological_process Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. [GOC:BHF, GOC:mah]
GO:0086004 regulation of cardiac muscle cell contraction biological_process Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
GO:0097190 apoptotic signaling pathway biological_process The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis]
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration biological_process Any process that regulates the concentration of calcium in the presynaptic cytosol. [GOC:dos]
GO:1900272 negative regulation of long-term synaptic potentiation biological_process Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]
GO:1900453 negative regulation of long-term synaptic depression biological_process Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0016323 basolateral plasma membrane cellular_component The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
GO:0030673 axolemma cellular_component The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]
GO:0032279 asymmetric synapse cellular_component A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. [GOC:dgh, GOC:ef]
GO:0042734 presynaptic membrane cellular_component A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
GO:0043025 neuronal cell body cellular_component The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
GO:0043195 terminal bouton cellular_component Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
GO:0043197 dendritic spine cellular_component A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
GO:0044305 calyx of Held cellular_component The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]
GO:0045211 postsynaptic membrane cellular_component A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]
GO:0048786 presynaptic active zone cellular_component A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
GO:0007186 G protein-coupled receptor signaling pathway biological_process The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
GO:0045202 synapse cellular_component The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
GO:0001609 G protein-coupled adenosine receptor activity molecular_function Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah, PMID:9755289]
GO:0030425 dendrite cellular_component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]