| GO term | GO name | GO namespace | GO def |
| GO:0120020 | cholesterol transfer activity | molecular_function | Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] |
| GO:0005102 | signaling receptor binding | molecular_function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| GO:0005319 | lipid transporter activity | molecular_function | Enables the directed movement of lipids into, out of or within a cell, or between cells. [GOC:ai] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005543 | phospholipid binding | molecular_function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| GO:0008289 | lipid binding | molecular_function | Binding to a lipid. [GOC:ai] |
| GO:0015485 | cholesterol binding | molecular_function | Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732] |
| GO:0019899 | enzyme binding | molecular_function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| GO:0031072 | heat shock protein binding | molecular_function | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw] |
| GO:0031210 | phosphatidylcholine binding | molecular_function | Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:mah, ISBN:0198506732] |
| GO:0034190 | apolipoprotein receptor binding | molecular_function | Binding to an apolipoprotein receptor. [GOC:BHF, GOC:rl] |
| GO:0042803 | protein homodimerization activity | molecular_function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| GO:0046982 | protein heterodimerization activity | molecular_function | Binding to a nonidentical protein to form a heterodimer. [GOC:ai] |
| GO:0055102 | lipase inhibitor activity | molecular_function | Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:rl] |
| GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity | molecular_function | Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615] |
| GO:0070653 | high-density lipoprotein particle receptor binding | molecular_function | Binding to a high-density lipoprotein receptor. [GOC:BHF, GOC:mah] |
| GO:0002719 | negative regulation of cytokine production involved in immune response | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. [GOC:add] |
| GO:0006641 | triglyceride metabolic process | biological_process | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [ISBN:0198506732] |
| GO:0006656 | phosphatidylcholine biosynthetic process | biological_process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [ISBN:0198506732] |
| GO:0009395 | phospholipid catabolic process | biological_process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| GO:0009410 | response to xenobiotic stimulus | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| GO:0009749 | response to glucose | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:jl] |
| GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling | biological_process | Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:tb] |
| GO:0018158 | protein oxidation | biological_process | The modification of a protein amino acid by oxidation. [GOC:ai] |
| GO:0018206 | peptidyl-methionine modification | biological_process | The modification of peptidyl-methionine. [GOC:go_curators] |
| GO:0030300 | regulation of intestinal cholesterol absorption | biological_process | Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption. [GOC:mah, PMID:11099417] |
| GO:0031100 | animal organ regeneration | biological_process | The regrowth of a lost or destroyed animal organ. [GOC:mah] |
| GO:0031647 | regulation of protein stability | biological_process | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb] |
| GO:0032375 | negative regulation of cholesterol transport | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| GO:0032757 | positive regulation of interleukin-8 production | biological_process | Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah] |
| GO:0033344 | cholesterol efflux | biological_process | The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:sart] |
| GO:0033700 | phospholipid efflux | biological_process | The directed movement of a phospholipid out of a cell or organelle. [GOC:mah] |
| GO:0034370 | triglyceride-rich lipoprotein particle remodeling | biological_process | The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
| GO:0034374 | low-density lipoprotein particle remodeling | biological_process | The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
| GO:0034375 | high-density lipoprotein particle remodeling | biological_process | The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
| GO:0034380 | high-density lipoprotein particle assembly | biological_process | The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. [GOC:BHF, GOC:mah] |
| GO:0034384 | high-density lipoprotein particle clearance | biological_process | The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah] |
| GO:0042632 | cholesterol homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| GO:0043627 | response to estrogen | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732] |
| GO:0043691 | reverse cholesterol transport | biological_process | The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. [GOC:ecd, PMID:7751809] |
| GO:0046340 | diacylglycerol catabolic process | biological_process | The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11717312] |
| GO:0050766 | positive regulation of phagocytosis | biological_process | Any process that activates or increases the frequency, rate or extent of phagocytosis. [GOC:ai] |
| GO:0050821 | protein stabilization | biological_process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| GO:0050995 | negative regulation of lipid catabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai] |
| GO:0050996 | positive regulation of lipid catabolic process | biological_process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai] |
| GO:0051384 | response to glucocorticoid | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123] |
| GO:0060192 | negative regulation of lipase activity | biological_process | Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. [GOC:dph, GOC:tb] |
| GO:0060621 | negative regulation of cholesterol import | biological_process | Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb] |
| GO:0060695 | negative regulation of cholesterol transporter activity | biological_process | Any process that decreases the rate, frequency, or extent of cholesterol transporter activity. [GOC:BHF, GOC:dph, GOC:tb] |
| GO:0120009 | intermembrane lipid transfer | biological_process | The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] |
| GO:1905920 | positive regulation of CoA-transferase activity | biological_process | Any process that activates or increases the frequency, rate or extent of CoA-transferase activity. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] |
| GO:0005576 | extracellular region | cellular_component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| GO:0005769 | early endosome | cellular_component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
| GO:0005788 | endoplasmic reticulum lumen | cellular_component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0070062 | extracellular exosome | cellular_component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| GO:0072562 | blood microparticle | cellular_component | A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184] |
| GO:0034361 | very-low-density lipoprotein particle | cellular_component | A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
| GO:0034364 | high-density lipoprotein particle | cellular_component | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl] |
| GO:0034366 | spherical high-density lipoprotein particle | cellular_component | A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
| GO:0042627 | chylomicron | cellular_component | A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. [GOC:jl, GOC:rl, PMID:10580165] |
| GO:0008035 | high-density lipoprotein particle binding | molecular_function | Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. [GOC:mah] |
| GO:0030301 | cholesterol transport | biological_process | The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, ISBN:0198506732] |