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ARID1A-201 ,ARID1A ,O14497
  • Uniprot Accession= O14497
  • Ensembl Transcript= ENST00000324856.13
  • Uniprot Name= ARID1A
  • Name= AT-rich interactive domain-containing protein 1A
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of GO Term: 31
GO term GO name GO namespace GO def
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0003713 transcription coactivator activity molecular_function A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0016922 nuclear receptor binding molecular_function Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]
GO:0006337 nucleosome disassembly biological_process The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. [GOC:mah]
GO:0006338 chromatin remodeling biological_process A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
GO:0006357 regulation of transcription by RNA polymerase II biological_process Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0007399 nervous system development biological_process The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
GO:0030071 regulation of mitotic metaphase/anaphase transition biological_process Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:mah]
GO:0030520 intracellular estrogen receptor signaling pathway biological_process The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
GO:0030521 androgen receptor signaling pathway biological_process The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah]
GO:0042921 glucocorticoid receptor signaling pathway biological_process The series of molecular signals initiated by glucocorticoid binding to its receptor. [GOC:mah]
GO:0045582 positive regulation of T cell differentiation biological_process Any process that activates or increases the frequency, rate or extent of T cell differentiation. [GOC:go_curators]
GO:0045597 positive regulation of cell differentiation biological_process Any process that activates or increases the frequency, rate or extent of cell differentiation. [GOC:go_curators]
GO:0045663 positive regulation of myoblast differentiation biological_process Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
GO:0045815 transcription initiation-coupled chromatin remodeling biological_process An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:34414474]
GO:0045893 positive regulation of DNA-templated transcription biological_process Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
GO:0070316 regulation of G0 to G1 transition biological_process A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]
GO:1902459 positive regulation of stem cell population maintenance biological_process Any process that activates or increases the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]
GO:2000045 regulation of G1/S transition of mitotic cell cycle biological_process Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
GO:2000781 positive regulation of double-strand break repair biological_process Any process that activates or increases the frequency, rate or extent of double-strand break repair. [GOC:BHF]
GO:2000819 regulation of nucleotide-excision repair biological_process Any process that modulates the frequency, rate or extent of nucleotide-excision repair. [GOC:jp, PMID:18836076]
GO:0000785 chromatin cellular_component The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0016514 SWI/SNF complex cellular_component A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. [GOC:bhm, PMID:12672490]
GO:0035060 brahma complex cellular_component A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. [GOC:bhm, PMID:10809665, PMID:12482982]
GO:0071564 npBAF complex cellular_component A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. [GOC:mah, GOC:ss, PMID:17640523]
GO:0071565 nBAF complex cellular_component A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [GOC:mah, GOC:ss, PMID:17640523]
GO:0140092 bBAF complex cellular_component A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581]
GO:0031491 nucleosome binding molecular_function Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]