Filter in search result
Please select a valid state.
ATP1A2-201 ,ATP1A2 ,P50993
  • Uniprot Accession= P50993
  • Ensembl Transcript= ENST00000361216.8
  • Uniprot Name= ATP1A2
  • Name= Sodium/potassium-transporting ATPase subunit alpha-2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 73
GO term GO name GO namespace GO def
GO:0001662 behavioral fear response biological_process An acute behavioral change resulting from a perceived external threat. [GOC:dph, PMID:9920659]
GO:0002026 regulation of the force of heart contraction biological_process Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:dph, GOC:tb, PMID:10358008]
GO:0002087 regulation of respiratory gaseous exchange by nervous system process biological_process A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. [GOC:dph, GOC:tb, PMID:12458206]
GO:0006937 regulation of muscle contraction biological_process Any process that modulates the frequency, rate or extent of muscle contraction. [GOC:go_curators]
GO:0021764 amygdala development biological_process The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
GO:0021989 olfactory cortex development biological_process The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
GO:0040011 locomotion biological_process Self-propelled movement of a cell or organism from one location to another. [GOC:dgh]
GO:0045822 negative regulation of heart contraction biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. [GOC:go_curators]
GO:0045823 positive regulation of heart contraction biological_process Any process that activates or increases the frequency, rate or extent of heart contraction. [GOC:go_curators]
GO:0051481 negative regulation of cytosolic calcium ion concentration biological_process Any process that decreases the concentration of calcium ions in the cytosol. [GOC:ai]
GO:0005391 P-type sodium:potassium-exchanging transporter activity molecular_function Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction
GO:0005496 steroid binding molecular_function Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005524 ATP binding molecular_function Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GO:0016791 phosphatase activity molecular_function Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. [GOC:curators, GOC:pg]
GO:0016887 ATP hydrolysis activity molecular_function Catalysis of the reaction
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity molecular_function Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction
GO:0030955 potassium ion binding molecular_function Binding to a potassium ion (K+). [GOC:mah]
GO:0031402 sodium ion binding molecular_function Binding to a sodium ion (Na+). [GOC:mah]
GO:0046982 protein heterodimerization activity molecular_function Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
GO:0051087 protein-folding chaperone binding molecular_function Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]
GO:1990239 steroid hormone binding molecular_function Binding to a steroid hormone. [GOC:ln]
GO:0001504 neurotransmitter uptake biological_process The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]
GO:0006813 potassium ion transport biological_process The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
GO:0006814 sodium ion transport biological_process The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
GO:0006883 intracellular sodium ion homeostasis biological_process A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]
GO:0006940 regulation of smooth muscle contraction biological_process Any process that modulates the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]
GO:0006942 regulation of striated muscle contraction biological_process Any process that modulates the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]
GO:0008217 regulation of blood pressure biological_process Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
GO:0008344 adult locomotory behavior biological_process Locomotory behavior in a fully developed and mature organism. [GOC:ai]
GO:0008542 visual learning biological_process Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. [GOC:jid, ISBN:0582227089]
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient biological_process The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion biological_process Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:BHF, GOC:dph, GOC:tb]
GO:0010996 response to auditory stimulus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
GO:0019229 regulation of vasoconstriction biological_process Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. [GOC:jl]
GO:0030007 intracellular potassium ion homeostasis biological_process A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah]
GO:0035094 response to nicotine biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
GO:0035641 locomotory exploration behavior biological_process The specific movement from place to place of an organism in response to a novel environment. [GOC:sart, PMID:17151232]
GO:0035725 sodium ion transmembrane transport biological_process A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
GO:0036376 sodium ion export across plasma membrane biological_process The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]
GO:0045988 negative regulation of striated muscle contraction biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]
GO:0046034 ATP metabolic process biological_process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse biological_process Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. [GOC:ai]
GO:0051966 regulation of synaptic transmission, glutamatergic biological_process Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
GO:0055119 relaxation of cardiac muscle biological_process The process in which the extent of cardiac muscle contraction is reduced. [GOC:ecd]
GO:0060048 cardiac muscle contraction biological_process Muscle contraction of cardiac muscle tissue. [GOC:dph]
GO:0071260 cellular response to mechanical stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah]
GO:0071383 cellular response to steroid hormone stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:mah]
GO:0071805 potassium ion transmembrane transport biological_process A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
GO:0086004 regulation of cardiac muscle cell contraction biological_process Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
GO:0086009 membrane repolarization biological_process The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
GO:0086012 membrane depolarization during cardiac muscle cell action potential biological_process The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
GO:0086064 cell communication by electrical coupling involved in cardiac conduction biological_process The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
GO:0098655 monoatomic cation transmembrane transport biological_process The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. [GOC:dos, GOC:vw]
GO:0150104 transport across blood-brain barrier biological_process The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
GO:1903170 negative regulation of calcium ion transmembrane transport biological_process Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]
GO:1903280 negative regulation of calcium:sodium antiporter activity biological_process Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
GO:1903416 response to glycoside biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus. [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970]
GO:1990573 potassium ion import across plasma membrane biological_process The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005768 endosome cellular_component A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0005901 caveola cellular_component A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]
GO:0014704 intercalated disc cellular_component A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0030315 T-tubule cellular_component Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]
GO:0031090 organelle membrane cellular_component A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. [GOC:dos, GOC:mah]
GO:0042995 cell projection cellular_component A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
GO:0043025 neuronal cell body cellular_component The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
GO:0043197 dendritic spine cellular_component A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
GO:1903561 extracellular vesicle cellular_component Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]
GO:0005890 sodium:potassium-exchanging ATPase complex cellular_component Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]
GO:1902600 proton transmembrane transport biological_process The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]