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BCL10-202 ,BCL10 ,O95999
  • Uniprot Accession= O95999
  • Ensembl Transcript= ENST00000648566.1
  • Uniprot Name= BCL10
  • Name= B-cell lymphoma/leukemia 10
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of GO Term: 55
GO term GO name GO namespace GO def
GO:0032755 positive regulation of interleukin-6 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
GO:0032761 positive regulation of lymphotoxin A production biological_process Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production. [GOC:mah]
GO:0032765 positive regulation of mast cell cytokine production biological_process Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production. [GOC:mah]
GO:0019209 kinase activator activity molecular_function Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]
GO:0002020 protease binding molecular_function Binding to a protease or a peptidase. [GOC:hjd]
GO:0003713 transcription coactivator activity molecular_function A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0031625 ubiquitin protein ligase binding molecular_function Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
GO:0042802 identical protein binding molecular_function Binding to an identical protein or proteins. [GOC:jl]
GO:0043422 protein kinase B binding molecular_function Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, http://www.heartandmetabolism.org/]
GO:0043621 protein self-association molecular_function Binding to a domain within the same polypeptide. [GOC:jl]
GO:0044877 protein-containing complex binding molecular_function Binding to a macromolecular complex. [GOC:jl]
GO:0050700 CARD domain binding molecular_function Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. [PMID:12054670]
GO:0051059 NF-kappaB binding molecular_function Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. [GOC:ai]
GO:0140296 general transcription initiation factor binding molecular_function Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. [GOC:txnOH-2018]
GO:0001783 B cell apoptotic process biological_process Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
GO:0001843 neural tube closure biological_process The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. [GOC:dph, ISBN:0878932437]
GO:0002224 toll-like receptor signaling pathway biological_process The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
GO:0002250 adaptive immune response biological_process An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
GO:0002906 negative regulation of mature B cell apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]
GO:0006968 cellular defense response biological_process A defense response that is mediated by cells. [GOC:ebc]
GO:0012501 programmed cell death biological_process A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. [GOC:lr, GOC:mtg_apoptosis]
GO:0016064 immunoglobulin mediated immune response biological_process An immune response mediated by immunoglobulins, whether cell-bound or in solution. [GO_REF:0000022, GOC:add, ISBN:0781735149]
GO:0031398 positive regulation of protein ubiquitination biological_process Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [GOC:mah, GOC:signaling, PMID:15379975]
GO:0032094 response to food biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. [GOC:add, ISBN:0721601464]
GO:0032757 positive regulation of interleukin-8 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
GO:0038061 non-canonical NF-kappaB signal transduction biological_process An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]
GO:0042327 positive regulation of phosphorylation biological_process Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. [GOC:jl]
GO:0043065 positive regulation of apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0045893 positive regulation of DNA-templated transcription biological_process Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
GO:0050852 T cell receptor signaling pathway biological_process The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add]
GO:0050862 positive regulation of T cell receptor signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]
GO:0050870 positive regulation of T cell activation biological_process Any process that activates or increases the frequency, rate or extent of T cell activation. [GOC:ai]
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
GO:0051260 protein homooligomerization biological_process The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]
GO:0061760 antifungal innate immune response biological_process An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [GOC:dph, PMID:22470487]
GO:0070231 T cell apoptotic process biological_process Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
GO:0071222 cellular response to lipopolysaccharide biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
GO:0071260 cellular response to mechanical stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah]
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
GO:0001772 immunological synapse cellular_component An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376300]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005764 lysosome cellular_component A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005881 cytoplasmic microtubule cellular_component Any microtubule in the cytoplasm of a cell. [GOC:mah]
GO:0045121 membrane raft cellular_component Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]
GO:0048471 perinuclear region of cytoplasm cellular_component Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
GO:0002096 polkadots cellular_component A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals. [PMID:14724296, PMID:16495340]
GO:0032449 CBM complex cellular_component A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation. [PMID:12909454, PMID:30467369]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]