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CDC42-208 ,CDC42 ,P60953
  • Uniprot Accession= P60953
  • Ensembl Transcript= ENST00000656825.1
  • Uniprot Name= CDC42
  • Name= Cell division control protein 42 homolog
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 97
GO term GO name GO namespace GO def
GO:0005813 centrosome cellular_component A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
GO:0003924 GTPase activity molecular_function Catalysis of the reaction
GO:0003925 G protein activity molecular_function A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). [PMID:16923326, PMID:24470015]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005525 GTP binding molecular_function Binding to GTP, guanosine triphosphate. [GOC:ai]
GO:0019901 protein kinase binding molecular_function Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
GO:0030742 GTP-dependent protein binding molecular_function Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. [GOC:go_curators, GOC:krc]
GO:0031435 mitogen-activated protein kinase kinase kinase binding molecular_function Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. [GOC:bf]
GO:0031996 thioesterase binding molecular_function Binding to a thioesterase. [GOC:dl]
GO:0032427 GBD domain binding molecular_function Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. [GOC:mah, GOC:pg, PMID:9119069]
GO:0034191 apolipoprotein A-I receptor binding molecular_function Binding to an apolipoprotein A-I receptor. [GOC:BHF, GOC:rl]
GO:0042802 identical protein binding molecular_function Binding to an identical protein or proteins. [GOC:jl]
GO:0061630 ubiquitin protein ligase activity molecular_function Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond
GO:0002040 sprouting angiogenesis biological_process The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. [PMID:16391003, PMID:23031691]
GO:0003161 cardiac conduction system development biological_process The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. [GOC:mtg_heart]
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis biological_process The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. [GOC:mtg_heart]
GO:0006911 phagocytosis, engulfment biological_process The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms
GO:0007015 actin filament organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:mah]
GO:0007030 Golgi organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. [GOC:dph, GOC:jl, GOC:mah]
GO:0007088 regulation of mitotic nuclear division biological_process Any process that modulates the frequency, rate or extent of mitosis. [GOC:go_curators]
GO:0007097 nuclear migration biological_process The directed movement of the nucleus to a specific location within a cell. [GOC:ai]
GO:0007163 establishment or maintenance of cell polarity biological_process Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. [GOC:mah]
GO:0007229 integrin-mediated signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
GO:0008104 protein localization biological_process Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]
GO:0010591 regulation of lamellipodium assembly biological_process Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]
GO:0010592 positive regulation of lamellipodium assembly biological_process Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]
GO:0021762 substantia nigra development biological_process The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]
GO:0030036 actin cytoskeleton organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
GO:0030225 macrophage differentiation biological_process The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]
GO:0030307 positive regulation of cell growth biological_process Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
GO:0030335 positive regulation of cell migration biological_process Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
GO:0031274 positive regulation of pseudopodium assembly biological_process Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]
GO:0031333 negative regulation of protein-containing complex assembly biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. [GOC:mah]
GO:0032467 positive regulation of cytokinesis biological_process Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]
GO:0032956 regulation of actin cytoskeleton organization biological_process Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah]
GO:0034329 cell junction assembly biological_process A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. [GOC:mah]
GO:0034332 adherens junction organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]
GO:0035050 embryonic heart tube development biological_process The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. [GOC:go_curators]
GO:0036336 dendritic cell migration biological_process The movement of a dendritic cell within or between different tissues and organs of the body. [CL:0000451, GOC:nhn, PMID:19339990]
GO:0038189 neuropilin signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, PMID:12852851]
GO:0043525 positive regulation of neuron apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]
GO:0044788 modulation by host of viral process biological_process A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. [GOC:jl]
GO:0045198 establishment of epithelial cell apical/basal polarity biological_process The specification and formation of the apicobasal polarity of an epithelial cell. [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
GO:0045740 positive regulation of DNA replication biological_process Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators]
GO:0046330 positive regulation of JNK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
GO:0046847 filopodium assembly biological_process The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
GO:0048549 positive regulation of pinocytosis biological_process Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]
GO:0048664 neuron fate determination biological_process The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dph]
GO:0051489 regulation of filopodium assembly biological_process Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]
GO:0051491 positive regulation of filopodium assembly biological_process Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]
GO:0051492 regulation of stress fiber assembly biological_process Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]
GO:0051496 positive regulation of stress fiber assembly biological_process Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]
GO:0051683 establishment of Golgi localization biological_process The directed movement of the Golgi to a specific location. [GOC:ai]
GO:0051835 positive regulation of synapse structural plasticity biological_process Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity. [GOC:ai]
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction biological_process Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
GO:0051988 regulation of attachment of spindle microtubules to kinetochore biological_process Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. [GOC:ai]
GO:0060047 heart contraction biological_process The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph]
GO:0060071 Wnt signaling pathway, planar cell polarity pathway biological_process A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton. [PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416]
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis biological_process Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. [GOC:dph]
GO:0060661 submandibular salivary gland formation biological_process The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed. [GOC:dph, PMID:17336109]
GO:0060997 dendritic spine morphogenesis biological_process The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]
GO:0071346 cellular response to type II interferon biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. [GOC:mah]
GO:0072384 organelle transport along microtubule biological_process The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. [GOC:mah]
GO:0086101 endothelin receptor signaling pathway involved in heart process biological_process An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
GO:0090135 actin filament branching biological_process The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments. [GOC:ascb_2009, GOC:dph, GOC:tb]
GO:0090316 positive regulation of intracellular protein transport biological_process Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. [GOC:tb]
GO:0099159 regulation of modification of postsynaptic structure biological_process Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. [GOC:dos]
GO:0099175 regulation of postsynapse organization biological_process Any process that modulates the physical form of a postsynapse. [GOC:ai, GOC:dph, GOC:tb]
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading biological_process Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]
GO:0000139 Golgi membrane cellular_component The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
GO:0000322 storage vacuole cellular_component A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. [GOC:krc]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005789 endoplasmic reticulum membrane cellular_component The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0005911 cell-cell junction cellular_component A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
GO:0005925 focal adhesion cellular_component A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0030141 secretory granule cellular_component A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]
GO:0030175 filopodium cellular_component Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. [GOC:mah, GOC:pr, ISBN:0815316194]
GO:0030496 midbody cellular_component A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194]
GO:0031256 leading edge membrane cellular_component The portion of the plasma membrane surrounding the leading edge of a motile cell. [GOC:mah]
GO:0036464 cytoplasmic ribonucleoprotein granule cellular_component A ribonucleoprotein granule located in the cytoplasm. [GOC:bf, GOC:PARL, PMID:15121898]
GO:0043005 neuron projection cellular_component A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
GO:0043025 neuronal cell body cellular_component The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
GO:0043197 dendritic spine cellular_component A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
GO:0045177 apical part of cell cellular_component The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194]
GO:0045335 phagocytic vesicle cellular_component A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732]
GO:0051233 spindle midzone cellular_component The area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749]
GO:0070062 extracellular exosome cellular_component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
GO:0072686 mitotic spindle cellular_component A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
GO:0098685 Schaffer collateral - CA1 synapse cellular_component A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]
GO:0098978 glutamatergic synapse cellular_component A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
GO:0017119 Golgi transport complex cellular_component A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
GO:0032488 Cdc42 protein signal transduction biological_process An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal. [GOC:mah, PMID:18558478]
GO:0006897 endocytosis biological_process A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]