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CDC73-201 ,CDC73 ,Q6P1J9
  • Uniprot Accession= Q6P1J9
  • Ensembl Transcript= ENST00000367435.5
  • Uniprot Name= CDC73
  • Name= Parafibromin
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of GO Term: 29
GO term
GO name
GO namespace
GO def
GO:0000993 RNA polymerase II complex binding molecular_function Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0001558 regulation of cell growth biological_process Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
GO:0001711 endodermal cell fate commitment biological_process The cell differentiation process that results in commitment of a cell to become part of the endoderm. [GOC:go_curators, ISBN:0878932437]
GO:0006368 transcription elongation by RNA polymerase II biological_process The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]
GO:0007049 cell cycle biological_process The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. [GOC:go_curators, GOC:mtg_cell_cycle]
GO:0008285 negative regulation of cell population proliferation biological_process Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
GO:0016055 Wnt signaling pathway biological_process The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]
GO:0019827 stem cell population maintenance biological_process The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms
GO:0030177 positive regulation of Wnt signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. [GOC:dph, GOC:go_curators, GOC:tb]
GO:0031124 mRNA 3'-end processing biological_process Any process involved in forming the mature 3' end of an mRNA molecule. [GOC:mah]
GO:0031442 positive regulation of mRNA 3'-end processing biological_process Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. [GOC:mah]
GO:0031648 protein destabilization biological_process Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah]
GO:0043066 negative regulation of apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0045638 negative regulation of myeloid cell differentiation biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
GO:0048147 negative regulation of fibroblast proliferation biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
GO:0050680 negative regulation of epithelial cell proliferation biological_process Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. [GOC:ai]
GO:0071222 cellular response to lipopolysaccharide biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
GO:1902808 positive regulation of cell cycle G1/S phase transition biological_process Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle biological_process Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
GO:0000781 chromosome, telomeric region cellular_component The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0016593 Cdc73/Paf1 complex cellular_component A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. [PMID:11884586]
GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex biological_process The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript. [PMID:18195044]
GO:0032968 positive regulation of transcription elongation by RNA polymerase II biological_process Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]