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CSF1-201 ,CSF1 ,P09603
  • Uniprot Accession= P09603
  • Ensembl Transcript= ENST00000329608.11
  • Uniprot Name= CSF1
  • Name= Macrophage colony-stimulating factor 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 55
GO term GO name GO namespace GO def
GO:0008284 positive regulation of cell population proliferation biological_process Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
GO:0005125 cytokine activity molecular_function The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]
GO:0005157 macrophage colony-stimulating factor receptor binding molecular_function Binding to a macrophage colony-stimulating factor receptor. [GOC:ai]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008083 growth factor activity molecular_function The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]
GO:0042802 identical protein binding molecular_function Binding to an identical protein or proteins. [GOC:jl]
GO:0042803 protein homodimerization activity molecular_function Binding to an identical protein to form a homodimer. [GOC:jl]
GO:0001780 neutrophil homeostasis biological_process The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]
GO:0001954 positive regulation of cell-matrix adhesion biological_process Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. [GOC:hjd]
GO:0002158 osteoclast proliferation biological_process The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. [CL:0000092, GOC:hjd]
GO:0002931 response to ischemia biological_process Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd]
GO:0003006 developmental process involved in reproduction biological_process A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. [GOC:dph, GOC:isa_complete]
GO:0006954 inflammatory response biological_process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
GO:0007265 Ras protein signal transduction biological_process An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]
GO:0010628 positive regulation of gene expression biological_process Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0010743 regulation of macrophage derived foam cell differentiation biological_process Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
GO:0010744 positive regulation of macrophage derived foam cell differentiation biological_process Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb]
GO:0010759 positive regulation of macrophage chemotaxis biological_process Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]
GO:0030224 monocyte differentiation biological_process The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]
GO:0030225 macrophage differentiation biological_process The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]
GO:0030278 regulation of ossification biological_process Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]
GO:0030316 osteoclast differentiation biological_process The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]
GO:0030335 positive regulation of cell migration biological_process Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
GO:0032946 positive regulation of mononuclear cell proliferation biological_process Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]
GO:0035702 monocyte homeostasis biological_process The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [CL:0000576, GOC:BHF, PMID:18832716]
GO:0038145 macrophage colony-stimulating factor signaling pathway biological_process The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor]
GO:0040018 positive regulation of multicellular organism growth biological_process Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:go_curators, GOC:tb]
GO:0042117 monocyte activation biological_process The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth biological_process Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. [GOC:jl, PMID:15355794]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0045651 positive regulation of macrophage differentiation biological_process Any process that activates or increases the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]
GO:0045657 positive regulation of monocyte differentiation biological_process Any process that activates or increases the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]
GO:0045672 positive regulation of osteoclast differentiation biological_process Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]
GO:0045860 positive regulation of protein kinase activity biological_process Any process that activates or increases the frequency, rate or extent of protein kinase activity. [GOC:go_curators]
GO:0046579 positive regulation of Ras protein signal transduction biological_process Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]
GO:0048873 homeostasis of number of cells within a tissue biological_process Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. [GOC:isa_complete]
GO:0051247 positive regulation of protein metabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]
GO:0060444 branching involved in mammary gland duct morphogenesis biological_process The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph]
GO:0060611 mammary gland fat development biological_process The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts. [GOC:dph]
GO:0060763 mammary duct terminal end bud growth biological_process The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty. [GOC:dph, PMID:10804170]
GO:0061518 microglial cell proliferation biological_process The expansion of a microglial cell population by cell division. [GOC:dph, PMID:17344397]
GO:0061519 macrophage homeostasis biological_process The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:dph, PMID:21727904]
GO:0097529 myeloid leukocyte migration biological_process The movement of a myeloid leukocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:22342843, PMID:24157461]
GO:1902228 positive regulation of macrophage colony-stimulating factor signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. [GOC:TermGenie, PMID:16705167]
GO:1904141 positive regulation of microglial cell migration biological_process Any process that activates or increases the frequency, rate or extent of microglial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
GO:1905523 positive regulation of macrophage migration biological_process Any process that activates or increases the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
GO:0005576 extracellular region cellular_component The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
GO:0005615 extracellular space cellular_component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
GO:0005788 endoplasmic reticulum lumen cellular_component The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0016604 nuclear body cellular_component Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
GO:0048471 perinuclear region of cytoplasm cellular_component Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
GO:1990682 CSF1-CSF1R complex cellular_component A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797]