| GO term | GO name | GO namespace | GO def |
| GO:0000781 | chromosome, telomeric region | cellular_component | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0008409 | 5'-3' exonuclease activity | molecular_function | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. [GOC:ai] |
| GO:0008800 | beta-lactamase activity | molecular_function | Catalysis of the reaction |
| GO:0042803 | protein homodimerization activity | molecular_function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| GO:0044877 | protein-containing complex binding | molecular_function | Binding to a macromolecular complex. [GOC:jl] |
| GO:0000723 | telomere maintenance | biological_process | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] |
| GO:0010833 | telomere maintenance via telomere lengthening | biological_process | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. [GOC:dph, GOC:tb] |
| GO:0016233 | telomere capping | biological_process | A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] |
| GO:0031627 | telomeric loop formation | biological_process | The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region. [GOC:vw, PMID:10338214] |
| GO:0031848 | protection from non-homologous end joining at telomere | biological_process | A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. [GOC:mah] |
| GO:0031860 | telomeric 3' overhang formation | biological_process | The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans. [PMID:16096639] |
| GO:0036297 | interstrand cross-link repair | biological_process | Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. [GOC:vw, PMID:16464006, PMID:22064477] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0005737 | cytoplasm | cellular_component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| GO:0005813 | centrosome | cellular_component | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684] |
| GO:0016604 | nuclear body | cellular_component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
| GO:0003684 | damaged DNA binding | molecular_function | Binding to damaged DNA. [GOC:jl] |
| GO:0035312 | 5'-3' DNA exonuclease activity | molecular_function | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. [ISBN:0198547684] |
| GO:0006303 | double-strand break repair via nonhomologous end joining | biological_process | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. [GOC:rph, PMID:10827453, PMID:24837021] |