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DCST1-201 ,DCST1 ,Q5T197
  • Uniprot Accession= Q5T197
  • Ensembl Transcript= ENST00000295542.6
  • Uniprot Name= DCST1
  • Name= E3 ubiquitin-protein ligase DCST1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 11
GO term GO name GO namespace GO def
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0061630 ubiquitin protein ligase activity molecular_function Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond
GO:0006511 ubiquitin-dependent protein catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. [GOC:go_curators]
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization biological_process The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head. [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
GO:0016567 protein ubiquitination biological_process The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
GO:0035036 sperm-egg recognition biological_process The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. [GOC:bf]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0060339 negative regulation of type I interferon-mediated signaling pathway biological_process Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]
GO:0002080 acrosomal membrane cellular_component The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. [GOC:dph]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]