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DFFA-202 ,DFFA ,O00273
  • Uniprot Accession= O00273
  • Ensembl Transcript= ENST00000377038.8
  • Uniprot Name= DFFA
  • Name= DNA fragmentation factor subunit alpha
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 17
GO term GO name GO namespace GO def
GO:1902511 negative regulation of apoptotic DNA fragmentation biological_process Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. [GOC:hjd, GOC:TermGenie, PMID:15572351]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0019904 protein domain specific binding molecular_function Binding to a specific domain of a protein. [GOC:go_curators]
GO:0044183 protein folding chaperone molecular_function Binding to a protein or a protein-containing complex to assist the protein folding process. [GOC:mtg_cambridge_2009]
GO:0060703 deoxyribonuclease inhibitor activity molecular_function Binds to and stops, prevents or reduces the activity of deoxyribonuclease. [GOC:dph, GOC:tb]
GO:0006309 apoptotic DNA fragmentation biological_process The cleavage of DNA during apoptosis, which usually occurs in two stages
GO:0032076 negative regulation of deoxyribonuclease activity biological_process Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. [GOC:mah]
GO:0043065 positive regulation of apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0061077 chaperone-mediated protein folding biological_process The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. [GOC:dph, GOC:vw]
GO:0070242 thymocyte apoptotic process biological_process Any apoptotic process in a thymocyte, an immature T cell located in the thymus. [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
GO:1900118 negative regulation of execution phase of apoptosis biological_process Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0000785 chromatin cellular_component The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]