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DHX9-201 ,DHX9 ,Q08211
  • Uniprot Accession= Q08211
  • Ensembl Transcript= ENST00000367549.4
  • Uniprot Name= DHX9
  • Name= ATP-dependent RNA helicase A
  • Chromosome= chr1
  • Driver status= Compendium
  • Number of GO Term: 98
GO term GO name GO namespace GO def
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
GO:0000993 RNA polymerase II complex binding molecular_function Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH]
GO:0001069 regulatory region RNA binding molecular_function Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. [GOC:txnOH]
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0003678 DNA helicase activity molecular_function Unwinding of a DNA helix, driven by ATP hydrolysis. [GOC:jl]
GO:0003688 DNA replication origin binding molecular_function Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. [GOC:curators]
GO:0003690 double-stranded DNA binding molecular_function Binding to double-stranded DNA. [GOC:elh, GOC:vw]
GO:0003697 single-stranded DNA binding molecular_function Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174]
GO:0003712 transcription coregulator activity molecular_function A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]
GO:0003713 transcription coactivator activity molecular_function A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
GO:0003723 RNA binding molecular_function Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
GO:0003724 RNA helicase activity molecular_function Unwinding of an RNA helix, driven by ATP hydrolysis. [GOC:jl, PMID:19158098]
GO:0003725 double-stranded RNA binding molecular_function Binding to double-stranded RNA. [GOC:jl]
GO:0003727 single-stranded RNA binding molecular_function Binding to single-stranded RNA. [GOC:jl]
GO:0003729 mRNA binding molecular_function Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005524 ATP binding molecular_function Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GO:0016887 ATP hydrolysis activity molecular_function Catalysis of the reaction
GO:0017111 ribonucleoside triphosphate phosphatase activity molecular_function Catalysis of the reaction
GO:0031490 chromatin DNA binding molecular_function Binding to DNA that is assembled into chromatin. [GOC:mah]
GO:0033679 3'-5' DNA/RNA helicase activity molecular_function Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis. [GOC:mah]
GO:0034458 3'-5' RNA helicase activity molecular_function Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis. [GOC:jp]
GO:0035197 siRNA binding molecular_function Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. [PMID:15066275, PMID:15066283]
GO:0035613 RNA stem-loop binding molecular_function Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. [GOC:sart, PMID:16568238, PMID:20455544]
GO:0043022 ribosome binding molecular_function Binding to a ribosome. [GOC:go_curators]
GO:0043138 3'-5' DNA helicase activity molecular_function Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. [EC:5.6.2.4, GOC:jl]
GO:0045142 triplex DNA binding molecular_function Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. [PMID:10681538]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0047429 nucleoside triphosphate diphosphatase activity molecular_function Catalysis of the reaction
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding molecular_function Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]
GO:0061676 importin-alpha family protein binding molecular_function Binding to a member of the importin-alpha family. [PMID:15350979, PMID:17170104, PMID:23734157]
GO:0070063 RNA polymerase binding molecular_function Binding to an RNA polymerase molecule or complex. [GOC:BHF, GOC:mah, GOC:txnOH]
GO:1905172 RISC complex binding molecular_function Binding to a RISC complex. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364]
GO:1905538 polysome binding molecular_function Binding to a polysome. [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
GO:1990518 single-stranded 3'-5' DNA helicase activity molecular_function Catalysis of the reaction
GO:1990825 sequence-specific mRNA binding molecular_function Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. [PMID:11886857]
GO:1990841 promoter-specific chromatin binding molecular_function Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]
GO:0000380 alternative mRNA splicing, via spliceosome biological_process The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. [GOC:krc, PMID:12110900]
GO:0001649 osteoblast differentiation biological_process The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid]
GO:0006260 DNA replication biological_process The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. [GOC:mah]
GO:0006353 DNA-templated transcription termination biological_process The completion of transcription
GO:0006357 regulation of transcription by RNA polymerase II biological_process Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0006954 inflammatory response biological_process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
GO:0010501 RNA secondary structure unwinding biological_process The process in which a secondary structure of RNA are broken or 'melted'. [PMID:17169986]
GO:0032508 DNA duplex unwinding biological_process The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. [GOC:isa_complete, GOC:mah]
GO:0032727 positive regulation of interferon-alpha production biological_process Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]
GO:0032728 positive regulation of interferon-beta production biological_process Any process that activates or increases the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]
GO:0032741 positive regulation of interleukin-18 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-18 production. [GOC:mah]
GO:0032755 positive regulation of interleukin-6 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
GO:0032760 positive regulation of tumor necrosis factor production biological_process Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
GO:0035195 miRNA-mediated post-transcriptional gene silencing biological_process A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms
GO:0039695 DNA-templated viral transcription biological_process A transcription process that uses a viral DNA as a template. [GOC:bf, GOC:jl]
GO:0044806 G-quadruplex DNA unwinding biological_process The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'. [GOC:jl, GOC:se, PMID:23657261]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0045089 positive regulation of innate immune response biological_process Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]
GO:0045739 positive regulation of DNA repair biological_process Any process that activates or increases the frequency, rate or extent of DNA repair. [GOC:go_curators]
GO:0045740 positive regulation of DNA replication biological_process Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators]
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
GO:0046833 positive regulation of RNA export from nucleus biological_process Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. [GOC:bf]
GO:0048146 positive regulation of fibroblast proliferation biological_process Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
GO:0048511 rhythmic process biological_process Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid]
GO:0050434 positive regulation of viral transcription biological_process Any process that activates or increases the frequency, rate or extent of viral transcription. [GOC:ai]
GO:0050684 regulation of mRNA processing biological_process Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. [GOC:ai]
GO:0050691 regulation of defense response to virus by host biological_process Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. [GOC:ai, GOC:dph]
GO:0050729 positive regulation of inflammatory response biological_process Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
GO:0051028 mRNA transport biological_process The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
GO:0060760 positive regulation of response to cytokine stimulus biological_process Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]
GO:0065003 protein-containing complex assembly biological_process The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl]
GO:0070269 pyroptosis biological_process A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. [GOC:mtg_apoptosis, PMID:18846107, PMID:21760595]
GO:0070922 RISC complex assembly biological_process The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA. [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]
GO:0070934 CRD-mediated mRNA stabilization biological_process An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). [GOC:mah, PMID:19029303]
GO:0071356 cellular response to tumor necrosis factor biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]
GO:0071360 cellular response to exogenous dsRNA biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. [GOC:mah]
GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay biological_process Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]
GO:1903608 protein localization to cytoplasmic stress granule biological_process A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule. [GO_REF:0000087, GOC:TermGenie, PMID:24755092]
GO:1904973 positive regulation of viral translation biological_process Any process that activates or increases the frequency, rate or extent of viral translation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity biological_process Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. [GOC:mah]
GO:2000765 regulation of cytoplasmic translation biological_process Any process that modulates the frequency, rate or extent of cytoplasmic translation. [GOC:obol]
GO:2000767 positive regulation of cytoplasmic translation biological_process Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. [GOC:obol]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005726 perichromatin fibrils cellular_component Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. [PMID:14731598]
GO:0005730 nucleolus cellular_component A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005813 centrosome cellular_component A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0015629 actin cytoskeleton cellular_component The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0016604 nuclear body cellular_component Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
GO:0036464 cytoplasmic ribonucleoprotein granule cellular_component A ribonucleoprotein granule located in the cytoplasm. [GOC:bf, GOC:PARL, PMID:15121898]
GO:0070937 CRD-mediated mRNA stability complex cellular_component A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. [GOC:mah, PMID:19029303]
GO:0097165 nuclear stress granule cellular_component A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:10359787, PMID:12865437]
GO:0016442 RISC complex cellular_component A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. [PMID:10749213, PMID:15145345]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
GO:0070578 RISC-loading complex cellular_component A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]
GO:1990904 ribonucleoprotein complex cellular_component A macromolecular complex that contains both RNA and protein molecules. [GOC:krc, GOC:vesicles]
GO:0005622 intracellular anatomical structure cellular_component A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. [ISBN:0198506732]