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DNAJC6-203 ,DNAJC6 ,O75061
  • Uniprot Accession= O75061
  • Ensembl Transcript= ENST00000395325.7
  • Uniprot Name= DNAJC6
  • Name= Putative tyrosine-protein phosphatase auxilin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 21
GO term GO name GO namespace GO def
GO:0004725 protein tyrosine phosphatase activity molecular_function Catalysis of the reaction
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0017124 SH3 domain binding molecular_function Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]
GO:0030276 clathrin binding molecular_function Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. [GOC:jl, GOC:mah, ISBN:0198506732]
GO:0031072 heat shock protein binding molecular_function Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw]
GO:0032050 clathrin heavy chain binding molecular_function Binding to a clathrin heavy chain. [GOC:mah]
GO:0016191 synaptic vesicle uncoating biological_process The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. [GOC:curators, PMID:10099709, PMID:24596248]
GO:0016311 dephosphorylation biological_process The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]
GO:0036465 synaptic vesicle recycling biological_process The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]
GO:0046907 intracellular transport biological_process The directed movement of substances within a cell. [GOC:ai]
GO:0072318 clathrin coat disassembly biological_process The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system. [PMID:11084334, PMID:11146663, PMID:8524399]
GO:0072583 clathrin-dependent endocytosis biological_process An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
GO:1905443 regulation of clathrin coat assembly biological_process Any process that modulates the frequency, rate or extent of clathrin coat assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940]
GO:2000369 regulation of clathrin-dependent endocytosis biological_process Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. [GOC:mah]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0030136 clathrin-coated vesicle cellular_component A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GOC:mah, PMID:11252894]
GO:0098894 extrinsic component of presynaptic endocytic zone membrane cellular_component The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]
GO:0031982 vesicle cellular_component Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0043231 intracellular membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0014069 postsynaptic density cellular_component An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]