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DVL1-201 ,DVL1 ,O14640
  • Uniprot Accession= O14640
  • Ensembl Transcript= ENST00000378888.10
  • Uniprot Name= DVL1
  • Name= Segment polarity protein dishevelled homolog DVL-1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 63
GO term GO name GO namespace GO def
GO:0005109 frizzled binding molecular_function Binding to a frizzled (fz) receptor. [GOC:ceb]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008013 beta-catenin binding molecular_function Binding to a catenin beta subunit. [GOC:bf]
GO:0019899 enzyme binding molecular_function Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
GO:0019901 protein kinase binding molecular_function Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
GO:0031267 small GTPase binding molecular_function Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
GO:0042802 identical protein binding molecular_function Binding to an identical protein or proteins. [GOC:jl]
GO:0001933 negative regulation of protein phosphorylation biological_process Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
GO:0001934 positive regulation of protein phosphorylation biological_process Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
GO:0001947 heart looping biological_process The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. [GOC:dph, PMID:12094232]
GO:0003151 outflow tract morphogenesis biological_process The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]
GO:0006355 regulation of DNA-templated transcription biological_process Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
GO:0007269 neurotransmitter secretion biological_process The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. [GOC:dph]
GO:0007411 axon guidance biological_process The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
GO:0007528 neuromuscular junction development biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. [GOC:mtg_OBO2OWL_2013]
GO:0010976 positive regulation of neuron projection development biological_process Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]
GO:0016079 synaptic vesicle exocytosis biological_process Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg]
GO:0021915 neural tube development biological_process The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
GO:0022007 convergent extension involved in neural plate elongation biological_process The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]
GO:0031122 cytoplasmic microtubule organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. [GOC:mah]
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]
GO:0032880 regulation of protein localization biological_process Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. [GOC:dph, GOC:mah, GOC:tb]
GO:0034504 protein localization to nucleus biological_process A process in which a protein transports or maintains the localization of another protein to the nucleus. [GOC:ecd]
GO:0035176 social behavior biological_process Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
GO:0035372 protein localization to microtubule biological_process A process in which a protein is transported to, or maintained at, a microtubule. [GOC:bf, GOC:lb]
GO:0035556 intracellular signal transduction biological_process The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
GO:0035567 non-canonical Wnt signaling pathway biological_process A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin. [PMID:37804416]
GO:0043113 receptor clustering biological_process The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
GO:0048668 collateral sprouting biological_process The process in which outgrowths develop from the shafts of existing axons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
GO:0048675 axon extension biological_process Long distance growth of a single axon process involved in cellular development. [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
GO:0048813 dendrite morphogenesis biological_process The process in which the anatomical structures of a dendrite are generated and organized. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]
GO:0050808 synapse organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:pr]
GO:0050821 protein stabilization biological_process Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]
GO:0060070 canonical Wnt signaling pathway biological_process A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488]
GO:0060071 Wnt signaling pathway, planar cell polarity pathway biological_process A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton. [PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416]
GO:0060134 prepulse inhibition biological_process The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. [GOC:dph, PMID:10341260]
GO:0060997 dendritic spine morphogenesis biological_process The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]
GO:0071340 skeletal muscle acetylcholine-gated channel clustering biological_process The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals. [GOC:bf, GOC:dsf, PMID:19285469]
GO:0090103 cochlea morphogenesis biological_process The process in which the cochlea is generated and organized. [GOC:dph, GOC:tb]
GO:0099054 presynapse assembly biological_process The aggregation, arrangement and bonding together of a set of components to form a presynapse. [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]
GO:0099175 regulation of postsynapse organization biological_process Any process that modulates the physical form of a postsynapse. [GOC:ai, GOC:dph, GOC:tb]
GO:0150012 positive regulation of neuron projection arborization biological_process Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. [GOC:aruk, GOC:bc, PMID:17114044]
GO:1905386 positive regulation of protein localization to presynapse biological_process Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
GO:2000300 regulation of synaptic vesicle exocytosis biological_process Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]
GO:2000463 positive regulation of excitatory postsynaptic potential biological_process Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:bf, GOC:BHF]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005874 microtubule cellular_component Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]
GO:0014069 postsynaptic density cellular_component An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
GO:0016328 lateral plasma membrane cellular_component The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]
GO:0030136 clathrin-coated vesicle cellular_component A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GOC:mah, PMID:11252894]
GO:0030426 growth cone cellular_component The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]
GO:0031410 cytoplasmic vesicle cellular_component A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
GO:0043005 neuron projection cellular_component A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
GO:0043025 neuronal cell body cellular_component The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
GO:0043197 dendritic spine cellular_component A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
GO:0045202 synapse cellular_component The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
GO:0098685 Schaffer collateral - CA1 synapse cellular_component A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]
GO:0098793 presynapse cellular_component The part of a synapse that is part of the presynaptic cell. [GOC:dos]
GO:0098978 glutamatergic synapse cellular_component A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
GO:0098992 neuronal dense core vesicle cellular_component A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]
GO:1990909 Wnt signalosome cellular_component A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]
GO:0090179 planar cell polarity pathway involved in neural tube closure biological_process The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure. [GOC:ascb_2009, GOC:dph, GOC:tb]