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ECE1-203 ,ECE1 ,P42892
  • Uniprot Accession= P42892
  • Ensembl Transcript= ENST00000374893.11
  • Uniprot Name= ECE1
  • Name= Endothelin-converting enzyme 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 35
GO term GO name GO namespace GO def
GO:0004175 endopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
GO:0004222 metalloendopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008270 zinc ion binding molecular_function Binding to a zinc ion (Zn). [GOC:ai]
GO:0017046 peptide hormone binding molecular_function Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
GO:0042803 protein homodimerization activity molecular_function Binding to an identical protein to form a homodimer. [GOC:jl]
GO:0001921 positive regulation of receptor recycling biological_process Any process that activates or increases the frequency, rate or extent of receptor recycling. [GOC:add]
GO:0003100 regulation of systemic arterial blood pressure by endothelin biological_process The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor. [GOC:mtg_cardio]
GO:0007186 G protein-coupled receptor signaling pathway biological_process The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
GO:0007507 heart development biological_process The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
GO:0010814 substance P catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P. [GOC:BHF, GOC:rl]
GO:0010815 bradykinin catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. [GOC:BHF, GOC:rl]
GO:0010816 calcitonin catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. [GOC:BHF, GOC:rl]
GO:0016485 protein processing biological_process Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
GO:0016486 peptide hormone processing biological_process The generation of a mature peptide hormone by posttranslational processing of a prohormone. [GOC:mah]
GO:0019229 regulation of vasoconstriction biological_process Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. [GOC:jl]
GO:0034959 endothelin maturation biological_process The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin. [GOC:BHF, GOC:rl]
GO:0035050 embryonic heart tube development biological_process The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. [GOC:go_curators]
GO:0042447 hormone catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]
GO:0042733 embryonic digit morphogenesis biological_process The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. [GOC:bf, GOC:jl, UBERON:0002544]
GO:0043583 ear development biological_process The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. [GOC:jl, ISBN:0192801023]
GO:0060037 pharyngeal system development biological_process The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming
GO:0060385 axonogenesis involved in innervation biological_process The neurite development process that generates a long process of a neuron, as it invades a target tissue. [GOC:dph, GOC:sart]
GO:0097492 sympathetic neuron axon guidance biological_process The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:rl, PMID:22790009]
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance biological_process Any semaphorin-plexin signaling pathway that is involved in axon guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
GO:0005765 lysosomal membrane cellular_component The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
GO:0005768 endosome cellular_component A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0009897 external side of plasma membrane cellular_component The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
GO:0010008 endosome membrane cellular_component The lipid bilayer surrounding an endosome. [GOC:mah]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0031982 vesicle cellular_component Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
GO:0033093 Weibel-Palade body cellular_component A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. [PMID:11935287, PMID:16087708]
GO:0048471 perinuclear region of cytoplasm cellular_component Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
GO:0070062 extracellular exosome cellular_component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]