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EIF2B3-201 ,EIF2B3 ,Q9NR50
  • Uniprot Accession= Q9NR50
  • Ensembl Transcript= ENST00000360403.7
  • Uniprot Name= EIF2B3
  • Name= Translation initiation factor eIF-2B subunit gamma
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 15
GO term GO name GO namespace GO def
GO:0003743 translation initiation factor activity molecular_function Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GO:0008135 translation factor activity, RNA binding molecular_function Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. [GOC:ai, GOC:vw]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0002183 cytoplasmic translational initiation biological_process The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [GOC:hjd]
GO:0006413 translational initiation biological_process The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [ISBN:019879276X]
GO:0009408 response to heat biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:lr]
GO:0009749 response to glucose biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:jl]
GO:0014003 oligodendrocyte development biological_process The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. [GOC:dgh, GOC:ef]
GO:0043434 response to peptide hormone biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
GO:0050852 T cell receptor signaling pathway biological_process The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005851 eukaryotic translation initiation factor 2B complex cellular_component A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. [PMID:9438375]
GO:0032045 guanyl-nucleotide exchange factor complex cellular_component A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah]