| GO term | GO name | GO namespace | GO def |
| GO:0001618 | virus receptor activity | molecular_function | Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | molecular_function | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| GO:0005003 | ephrin receptor activity | molecular_function | Combining with an ephrin receptor ligand to initiate a change in cell activity. [GOC:mah, PMID:9530499] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0019838 | growth factor binding | molecular_function | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators] |
| GO:0045296 | cadherin binding | molecular_function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| GO:0140677 | molecular function activator activity | molecular_function | A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators] |
| GO:0001501 | skeletal system development | biological_process | The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb] |
| GO:0001570 | vasculogenesis | biological_process | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. [PMID:8999798] |
| GO:0001649 | osteoblast differentiation | biological_process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid] |
| GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis | biological_process | The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis. [GOC:dph, GOC:tb, PMID:16391003] |
| GO:0006954 | inflammatory response | biological_process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| GO:0007155 | cell adhesion | biological_process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | biological_process | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis] |
| GO:0010591 | regulation of lamellipodium assembly | biological_process | Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb] |
| GO:0014028 | notochord formation | biological_process | The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. [GOC:dh, GOC:ef] |
| GO:0016310 | phosphorylation | biological_process | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732] |
| GO:0016477 | cell migration | biological_process | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] |
| GO:0016525 | negative regulation of angiogenesis | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators] |
| GO:0021915 | neural tube development | biological_process | The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| GO:0030182 | neuron differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah] |
| GO:0030216 | keratinocyte differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] |
| GO:0030316 | osteoclast differentiation | biological_process | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] |
| GO:0030335 | positive regulation of cell migration | biological_process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| GO:0032682 | negative regulation of chemokine production | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. [GOC:mah] |
| GO:0033598 | mammary gland epithelial cell proliferation | biological_process | The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:mah] |
| GO:0033628 | regulation of cell adhesion mediated by integrin | biological_process | Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add] |
| GO:0036342 | post-anal tail morphogenesis | biological_process | The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. [GOC:bf, GOC:kmv, Wikipedia:Chordate] |
| GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | biological_process | An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. [PMID:20517722, PMID:22952397] |
| GO:0043535 | regulation of blood vessel endothelial cell migration | biological_process | Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators] |
| GO:0045765 | regulation of angiogenesis | biological_process | Any process that modulates the frequency, rate or extent of angiogenesis. [GOC:go_curators] |
| GO:0046058 | cAMP metabolic process | biological_process | The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [GOC:go_curators] |
| GO:0046718 | symbiont entry into host cell | biological_process | The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl] |
| GO:0046849 | bone remodeling | biological_process | The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. [GOC:curators] |
| GO:0048013 | ephrin receptor signaling pathway | biological_process | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb] |
| GO:0048320 | axial mesoderm formation | biological_process | The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:dgh] |
| GO:0048870 | cell motility | biological_process | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] |
| GO:0050830 | defense response to Gram-positive bacterium | biological_process | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai] |
| GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] |
| GO:0060035 | notochord cell development | biological_process | The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph] |
| GO:0060326 | cell chemotaxis | biological_process | The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph] |
| GO:0060444 | branching involved in mammary gland duct morphogenesis | biological_process | The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph] |
| GO:0070309 | lens fiber cell morphogenesis | biological_process | The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735] |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | biological_process | Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
| GO:0070848 | response to growth factor | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:BHF, GOC:mah] |
| GO:0072659 | protein localization to plasma membrane | biological_process | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah] |
| GO:0090630 | activation of GTPase activity | biological_process | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. [GOC:dph, GOC:mah, GOC:tb] |
| GO:1901491 | negative regulation of lymphangiogenesis | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis. [GOC:dph, GOC:TermGenie, PMID:20133819] |
| GO:1903078 | positive regulation of protein localization to plasma membrane | biological_process | Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] |
| GO:1903348 | positive regulation of bicellular tight junction assembly | biological_process | Any process that activates or increases the frequency, rate or extent of tight junction assembly. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] |
| GO:1904238 | pericyte cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830] |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0005925 | focal adhesion | cellular_component | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] |
| GO:0009986 | cell surface | cellular_component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| GO:0030027 | lamellipodium | cellular_component | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194] |
| GO:0031256 | leading edge membrane | cellular_component | The portion of the plasma membrane surrounding the leading edge of a motile cell. [GOC:mah] |
| GO:0031258 | lamellipodium membrane | cellular_component | The portion of the plasma membrane surrounding a lamellipodium. [GOC:mah] |
| GO:0032587 | ruffle membrane | cellular_component | The portion of the plasma membrane surrounding a ruffle. [GOC:mah] |
| GO:0070160 | tight junction | cellular_component | A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [ISBN:0815332181] |
| GO:0007275 | multicellular organism development | biological_process | The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological_process | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling] |
| GO:0043235 | receptor complex | cellular_component | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators] |
| GO:0033674 | positive regulation of kinase activity | biological_process | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah] |