| GO term | GO name | GO namespace | GO def |
| GO:0006469 | negative regulation of protein kinase activity | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. [GOC:go_curators] |
| GO:2000785 | regulation of autophagosome assembly | biological_process | Any process that modulates the frequency, rate or extent of autophagosome assembly. [GOC:autophagy, GOC:BHF] |
| GO:0001540 | amyloid-beta binding | molecular_function | Binding to an amyloid-beta peptide/protein. [GOC:hjd] |
| GO:0004713 | protein tyrosine kinase activity | molecular_function | Catalysis of the reaction |
| GO:0005005 | transmembrane-ephrin receptor activity | molecular_function | Combining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499] |
| GO:0005102 | signaling receptor binding | molecular_function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0008046 | axon guidance receptor activity | molecular_function | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666] |
| GO:0042802 | identical protein binding | molecular_function | Binding to an identical protein or proteins. [GOC:jl] |
| GO:0044877 | protein-containing complex binding | molecular_function | Binding to a macromolecular complex. [GOC:jl] |
| GO:0001525 | angiogenesis | biological_process | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453] |
| GO:0001655 | urogenital system development | biological_process | The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. [GOC:go_curators] |
| GO:0001933 | negative regulation of protein phosphorylation | biological_process | Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. [GOC:hjd] |
| GO:0002639 | positive regulation of immunoglobulin production | biological_process | Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. [GOC:add] |
| GO:0007162 | negative regulation of cell adhesion | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. [GOC:go_curators] |
| GO:0007399 | nervous system development | biological_process | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh] |
| GO:0007411 | axon guidance | biological_process | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437] |
| GO:0007413 | axonal fasciculation | biological_process | The collection of axons into a bundle of rods, known as a fascicle. [GOC:dgh] |
| GO:0007611 | learning or memory | biological_process | The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125] |
| GO:0007612 | learning | biological_process | Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. [ISBN:0582227089, ISBN:0721662544] |
| GO:0010628 | positive regulation of gene expression | biological_process | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| GO:0016310 | phosphorylation | biological_process | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732] |
| GO:0018108 | peptidyl-tyrosine phosphorylation | biological_process | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039] |
| GO:0021631 | optic nerve morphogenesis | biological_process | The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| GO:0021934 | hindbrain tangential cell migration | biological_process | The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| GO:0021952 | central nervous system projection neuron axonogenesis | biological_process | Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| GO:0022038 | corpus callosum development | biological_process | The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] |
| GO:0030193 | regulation of blood coagulation | biological_process | Any process that modulates the frequency, rate or extent of blood coagulation. [GOC:mah] |
| GO:0030335 | positive regulation of cell migration | biological_process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| GO:0030890 | positive regulation of B cell proliferation | biological_process | Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah] |
| GO:0031290 | retinal ganglion cell axon guidance | biological_process | The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:ejs] |
| GO:0031915 | positive regulation of synaptic plasticity | biological_process | A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:mah] |
| GO:0032760 | positive regulation of tumor necrosis factor production | biological_process | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120] |
| GO:0042113 | B cell activation | biological_process | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149] |
| GO:0042472 | inner ear morphogenesis | biological_process | The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023] |
| GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | biological_process | Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT. [GOC:bf] |
| GO:0046580 | negative regulation of Ras protein signal transduction | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction. [GOC:bf] |
| GO:0048013 | ephrin receptor signaling pathway | biological_process | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb] |
| GO:0048168 | regulation of neuronal synaptic plasticity | biological_process | A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:jid, PMID:11891290] |
| GO:0048170 | positive regulation of long-term neuronal synaptic plasticity | biological_process | A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290] |
| GO:0048593 | camera-type eye morphogenesis | biological_process | The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:jid, GOC:mtg_sensu] |
| GO:0050771 | negative regulation of axonogenesis | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. [GOC:ai] |
| GO:0050878 | regulation of body fluid levels | biological_process | Any process that modulates the levels of body fluids. [GOC:ai, GOC:dph, GOC:tb] |
| GO:0051489 | regulation of filopodium assembly | biological_process | Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb] |
| GO:0051965 | positive regulation of synapse assembly | biological_process | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr] |
| GO:0060021 | roof of mouth development | biological_process | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. [GOC:dph, ISBN:0721662544] |
| GO:0060996 | dendritic spine development | biological_process | The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph] |
| GO:0060997 | dendritic spine morphogenesis | biological_process | The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph] |
| GO:0061003 | positive regulation of dendritic spine morphogenesis | biological_process | Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph] |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
| GO:0071222 | cellular response to lipopolysaccharide | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah] |
| GO:0071679 | commissural neuron axon guidance | biological_process | The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:mah] |
| GO:0097104 | postsynaptic membrane assembly | biological_process | The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). [GOC:BHF, GOC:sjp, PMID:21424692] |
| GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission | biological_process | Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. [GOC:dos, PMID:19029886] |
| GO:0106028 | neuron projection retraction | biological_process | The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:aruk, GOC:bc, PMID:11585923] |
| GO:0110077 | vesicle-mediated intercellular transport | biological_process | A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. [GOC:sp, PMID:29328915, PMID:29328916] |
| GO:0120192 | tight junction assembly | biological_process | A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [GOC:rl] |
| GO:1900016 | negative regulation of cytokine production involved in inflammatory response | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie] |
| GO:1900273 | positive regulation of long-term synaptic potentiation | biological_process | Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie] |
| GO:1903078 | positive regulation of protein localization to plasma membrane | biological_process | Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] |
| GO:1904646 | cellular response to amyloid-beta | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824] |
| GO:1904782 | negative regulation of NMDA glutamate receptor activity | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857] |
| GO:1904783 | positive regulation of NMDA glutamate receptor activity | biological_process | Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857] |
| GO:2000010 | positive regulation of protein localization to cell surface | biological_process | Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. [GOC:obol] |
| GO:2000316 | regulation of T-helper 17 type immune response | biological_process | Any process that modulates the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah] |
| GO:2000822 | regulation of behavioral fear response | biological_process | Any process that modulates the frequency, rate or extent of behavioral fear response. [GOC:BHF] |
| GO:0005576 | extracellular region | cellular_component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0009986 | cell surface | cellular_component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| GO:0030424 | axon | cellular_component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| GO:0030425 | dendrite | cellular_component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| GO:0042734 | presynaptic membrane | cellular_component | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194] |
| GO:0043025 | neuronal cell body | cellular_component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| GO:0043197 | dendritic spine | cellular_component | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln] |
| GO:0045211 | postsynaptic membrane | cellular_component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
| GO:0098686 | hippocampal mossy fiber to CA3 synapse | cellular_component | One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762] |
| GO:0098794 | postsynapse | cellular_component | The part of a synapse that is part of the post-synaptic cell. [GOC:dos] |
| GO:0098978 | glutamatergic synapse | cellular_component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
| GO:0006468 | protein phosphorylation | biological_process | The process of introducing a phosphate group on to a protein. [GOC:hb] |