| GO term | GO name | GO namespace | GO def |
| GO:0045576 | mast cell activation | biological_process | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. [GOC:mgi_curators, ISBN:0781735149] |
| GO:0001540 | amyloid-beta binding | molecular_function | Binding to an amyloid-beta peptide/protein. [GOC:hjd] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0019772 | low-affinity IgG receptor activity | molecular_function | Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149] |
| GO:0019864 | IgG binding | molecular_function | Binding to an immunoglobulin of an IgG isotype. [GOC:add, ISBN:0781735149] |
| GO:0044877 | protein-containing complex binding | molecular_function | Binding to a macromolecular complex. [GOC:jl] |
| GO:0001811 | negative regulation of type I hypersensitivity | biological_process | Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149] |
| GO:0001814 | negative regulation of antibody-dependent cellular cytotoxicity | biological_process | Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity. [GOC:add, ISBN:0781735149] |
| GO:0001818 | negative regulation of cytokine production | biological_process | Any process that stops, prevents, or reduces the rate of production of a cytokine. [GOC:add, ISBN:0781735149] |
| GO:0002252 | immune effector process | biological_process | Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| GO:0002266 | follicular dendritic cell activation | biological_process | A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:add, PMID:15606789] |
| GO:0002313 | mature B cell differentiation involved in immune response | biological_process | The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. [GOC:jal] |
| GO:0002316 | follicular B cell differentiation | biological_process | The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region. [GOC:jal, ISBN:0781735149] |
| GO:0002436 | immune complex clearance by monocytes and macrophages | biological_process | The process of immune complex clearance by monocytes or macrophages. [GOC:add, ISBN:0781735149] |
| GO:0002605 | negative regulation of dendritic cell antigen processing and presentation | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add] |
| GO:0002622 | regulation of B cell antigen processing and presentation | biological_process | Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add] |
| GO:0002638 | negative regulation of immunoglobulin production | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. [GOC:add] |
| GO:0002819 | regulation of adaptive immune response | biological_process | Any process that modulates the frequency, rate, or extent of an adaptive immune response. [GOC:add] |
| GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add] |
| GO:0002922 | positive regulation of humoral immune response | biological_process | Any process that activates or increases the frequency, rate, or extent of a humoral immune response. [GOC:add] |
| GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add] |
| GO:0006898 | receptor-mediated endocytosis | biological_process | An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363] |
| GO:0006909 | phagocytosis | biological_process | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732] |
| GO:0006911 | phagocytosis, engulfment | biological_process | The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms |
| GO:0006952 | defense response | biological_process | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. [GOC:go_curators] |
| GO:0006954 | inflammatory response | biological_process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| GO:0009617 | response to bacterium | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb] |
| GO:0010469 | regulation of signaling receptor activity | biological_process | Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. [GOC:dph, GOC:tb] |
| GO:0016064 | immunoglobulin mediated immune response | biological_process | An immune response mediated by immunoglobulins, whether cell-bound or in solution. [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | biological_process | The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. [GOC:add, ISBN:0781735149, PMID:15771591] |
| GO:0021549 | cerebellum development | biological_process | The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| GO:0030889 | negative regulation of B cell proliferation | biological_process | Any process that stops, prevents or reduces the rate or extent of B cell proliferation. [GOC:mah] |
| GO:0032693 | negative regulation of interleukin-10 production | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. [GOC:mah] |
| GO:0038094 | Fc-gamma receptor signaling pathway | biological_process | The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, PMID:11244038] |
| GO:0043031 | negative regulation of macrophage activation | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. [GOC:jl] |
| GO:0043318 | negative regulation of cytotoxic T cell degranulation | biological_process | Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. [ISBN:0781735149] |
| GO:0045088 | regulation of innate immune response | biological_process | Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc] |
| GO:0046330 | positive regulation of JNK cascade | biological_process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf] |
| GO:0050765 | negative regulation of phagocytosis | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. [GOC:ai] |
| GO:0050766 | positive regulation of phagocytosis | biological_process | Any process that activates or increases the frequency, rate or extent of phagocytosis. [GOC:ai] |
| GO:0050777 | negative regulation of immune response | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai] |
| GO:0050859 | negative regulation of B cell receptor signaling pathway | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai] |
| GO:0050869 | negative regulation of B cell activation | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. [GOC:ai] |
| GO:0071219 | cellular response to molecule of bacterial origin | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. [GOC:mah] |
| GO:0090264 | regulation of immune complex clearance by monocytes and macrophages | biological_process | Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. [GOC:tb] |
| GO:1902564 | negative regulation of neutrophil activation | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation. [GOC:TermGenie, PMID:17588661] |
| GO:1902950 | regulation of dendritic spine maintenance | biological_process | Any process that modulates the frequency, rate or extent of dendritic spine maintenance. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] |
| GO:1903381 | regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway | biological_process | Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] |
| GO:1904646 | cellular response to amyloid-beta | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824] |
| GO:1905898 | positive regulation of response to endoplasmic reticulum stress | biological_process | Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] |
| GO:2001199 | negative regulation of dendritic cell differentiation | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. [GOC:obol] |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0009897 | external side of plasma membrane | cellular_component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| GO:0043197 | dendritic spine | cellular_component | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln] |
| GO:0044297 | cell body | cellular_component | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators] |
| GO:0019770 | IgG receptor activity | molecular_function | Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149] |
| GO:0001788 | antibody-dependent cellular cytotoxicity | biological_process | Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795] |
| GO:0007166 | cell surface receptor signaling pathway | biological_process | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] |
| GO:0032760 | positive regulation of tumor necrosis factor production | biological_process | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120] |