| GO term | GO name | GO namespace | GO def |
| GO:0005856 | cytoskeleton | cellular_component | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875] |
| GO:0015629 | actin cytoskeleton | cellular_component | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194] |
| GO:0032587 | ruffle membrane | cellular_component | The portion of the plasma membrane surrounding a ruffle. [GOC:mah] |
| GO:0001784 | phosphotyrosine residue binding | molecular_function | Binding to a phosphorylated tyrosine residue within a protein. [PMID:14636584] |
| GO:0004713 | protein tyrosine kinase activity | molecular_function | Catalysis of the reaction |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | molecular_function | Catalysis of the reaction |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0019901 | protein kinase binding | molecular_function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| GO:0034987 | immunoglobulin receptor binding | molecular_function | Binding to one or more specific sites on an immunoglobulin receptor molecule. [GOC:BHF, GOC:vk] |
| GO:0034988 | Fc-gamma receptor I complex binding | molecular_function | Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. [GOC:BHF, GOC:vk] |
| GO:0001819 | positive regulation of cytokine production | biological_process | Any process that activates or increases the frequency, rate or extent of production of a cytokine. [GOC:add, ISBN:0781735149] |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | biological_process | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. [GOC:add, ISBN:0781735149, PMID:15771571] |
| GO:0002862 | negative regulation of inflammatory response to antigenic stimulus | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add] |
| GO:0006468 | protein phosphorylation | biological_process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
| GO:0007229 | integrin-mediated signaling pathway | biological_process | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling] |
| GO:0008360 | regulation of cell shape | biological_process | Any process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb] |
| GO:0009615 | response to virus | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb] |
| GO:0018108 | peptidyl-tyrosine phosphorylation | biological_process | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039] |
| GO:0030282 | bone mineralization | biological_process | The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354] |
| GO:0030335 | positive regulation of cell migration | biological_process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| GO:0032815 | negative regulation of natural killer cell activation | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. [GOC:mah] |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | biological_process | An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GOC:phg, PMID:12488490, PMID:15466916] |
| GO:0043306 | positive regulation of mast cell degranulation | biological_process | Any process that activates or increases the frequency, rate or extent of mast cell degranulation. [ISBN:0781735149] |
| GO:0045088 | regulation of innate immune response | biological_process | Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc] |
| GO:0045859 | regulation of protein kinase activity | biological_process | Any process that modulates the frequency, rate or extent of protein kinase activity. [GOC:go_curators] |
| GO:0046777 | protein autophosphorylation | biological_process | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732] |
| GO:0048705 | skeletal system morphogenesis | biological_process | The process in which the anatomical structures of the skeleton are generated and organized. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] |
| GO:0050764 | regulation of phagocytosis | biological_process | Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai] |
| GO:0050830 | defense response to Gram-positive bacterium | biological_process | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai] |
| GO:0051450 | myoblast proliferation | biological_process | The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ai, GOC:mtg_muscle] |
| GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | biological_process | Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] |
| GO:0005576 | extracellular region | cellular_component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| GO:0005743 | mitochondrial inner membrane | cellular_component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
| GO:0005758 | mitochondrial intermembrane space | cellular_component | The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0016235 | aggresome | cellular_component | An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. [PMID:11121744] |
| GO:0034774 | secretory granule lumen | cellular_component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| GO:0070062 | extracellular exosome | cellular_component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| GO:0030154 | cell differentiation | biological_process | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological_process | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling] |
| GO:0005102 | signaling receptor binding | molecular_function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| GO:0045087 | innate immune response | biological_process | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] |