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GADD45A-202 ,GADD45A ,P24522
  • Uniprot Accession= P24522
  • Ensembl Transcript= ENST00000370986.9
  • Uniprot Name= GADD45A
  • Name= Growth arrest and DNA damage-inducible protein GADD45 alpha
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 26
GO term GO name GO namespace GO def
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0019900 kinase binding molecular_function Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]
GO:0042803 protein homodimerization activity molecular_function Binding to an identical protein to form a homodimer. [GOC:jl]
GO:0046982 protein heterodimerization activity molecular_function Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
GO:1990841 promoter-specific chromatin binding molecular_function Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity biological_process Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0006281 DNA repair biological_process The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
GO:0006915 apoptotic process biological_process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
GO:0007098 centrosome cycle biological_process The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. [ISBN:0815316194]
GO:0016525 negative regulation of angiogenesis biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators]
GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:mah]
GO:0042770 signal transduction in response to DNA damage biological_process A cascade of processes induced by the detection of DNA damage within a cell. [GOC:go_curators]
GO:0043065 positive regulation of apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0043537 negative regulation of blood vessel endothelial cell migration biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]
GO:0046330 positive regulation of JNK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
GO:0071260 cellular response to mechanical stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah]
GO:0071479 cellular response to ionizing radiation biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [GOC:mah]
GO:0071901 negative regulation of protein serine/threonine kinase activity biological_process Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:BHF, GOC:mah]
GO:1900745 positive regulation of p38MAPK cascade biological_process Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]
GO:2000379 positive regulation of reactive oxygen species metabolic process biological_process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0016607 nuclear speck cellular_component A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]
GO:0051726 regulation of cell cycle biological_process Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]