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GCLM-201 ,GCLM ,P48507
  • Uniprot Accession= P48507
  • Ensembl Transcript= ENST00000370238.8
  • Uniprot Name= GCLM
  • Name= Glutamate--cysteine ligase regulatory subunit
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 29
GO term GO name GO namespace GO def
GO:0004357 glutamate-cysteine ligase activity molecular_function Catalysis of the reaction
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0035226 glutamate-cysteine ligase catalytic subunit binding molecular_function Binding to the catalytic subunit of glutamate-cysteine ligase. [PMID:12954617]
GO:0044877 protein-containing complex binding molecular_function Binding to a macromolecular complex. [GOC:jl]
GO:0006534 cysteine metabolic process biological_process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]
GO:0006536 glutamate metabolic process biological_process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators]
GO:0006750 glutathione biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]
GO:0006979 response to oxidative stress biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
GO:0007584 response to nutrient biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]
GO:0008637 apoptotic mitochondrial changes biological_process The morphological and physiological alterations undergone by mitochondria during apoptosis. [GOC:mah, GOC:mtg_apoptosis]
GO:0009410 response to xenobiotic stimulus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
GO:0014823 response to activity biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. [GOC:mtg_muscle]
GO:0035729 cellular response to hepatocyte growth factor stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. [GOC:bf]
GO:0035733 hepatic stellate cell activation biological_process A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor. [CL:0000632, GOC:bf]
GO:0043524 negative regulation of neuron apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
GO:0044344 cellular response to fibroblast growth factor stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. [GOC:jl, GOC:yaf]
GO:0044752 response to human chorionic gonadotropin biological_process Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. [PMID:21325635]
GO:0051409 response to nitrosative stress biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [PMID:15925705]
GO:0051900 regulation of mitochondrial depolarization biological_process Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]
GO:0071333 cellular response to glucose stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah]
GO:0071372 cellular response to follicle-stimulating hormone stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]
GO:0097069 cellular response to thyroxine stimulus biological_process A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. [GOC:sjw, PMID:9916872]
GO:0097746 blood vessel diameter maintenance biological_process Any process that modulates the diameter of blood vessels. [GOC:pr]
GO:1990830 cellular response to leukemia inhibitory factor biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway biological_process Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0017109 glutamate-cysteine ligase complex cellular_component An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. [PMID:9675072]
GO:0030234 enzyme regulator activity molecular_function Binds to and modulates the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]
GO:0035229 positive regulation of glutamate-cysteine ligase activity biological_process Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate. [PMID:12954617]