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GJC2-201 ,GJC2 ,Q5T442
  • Uniprot Accession= Q5T442
  • Ensembl Transcript= ENST00000366714.3
  • Uniprot Name= GJC2
  • Name= Gap junction gamma-2 protein
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 17
GO term GO name GO namespace GO def
GO:1903763 gap junction channel activity involved in cell communication by electrical coupling molecular_function Any gap junction channel activity that is involved in cell communication by electrical coupling. [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307]
GO:0001932 regulation of protein phosphorylation biological_process Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. [GOC:hjd]
GO:0009636 response to toxic substance biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr]
GO:0010628 positive regulation of gene expression biological_process Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0010644 cell communication by electrical coupling biological_process The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]
GO:0055085 transmembrane transport biological_process The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation biological_process Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation. [GOC:mah, GOC:sl]
GO:1904427 positive regulation of calcium ion transmembrane transport biological_process Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:22910094]
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle biological_process Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
GO:0005921 gap junction cellular_component A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins. [GOC:mah, GOC:mtg_muscle, ISBN:0815332181, PMID:22366062, Wikipedia:Gap_junction]
GO:0033270 paranode region of axon cellular_component An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]
GO:0043204 perikaryon cellular_component The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
GO:0043209 myelin sheath cellular_component An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells
GO:1990769 proximal neuron projection cellular_component The portion of an axon or dendrite that is close to the neuronal cell body. [PMID:21104189]
GO:0007267 cell-cell signaling biological_process Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
GO:0005243 gap junction channel activity molecular_function A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]
GO:0005922 connexin complex cellular_component An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. [PMID:11146276]