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Total number of protein in "GO:0000165" GO term:  117

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ADRA1A-204 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0000165 Not Cancer Driver No 90 0.1931330472103004 40 1 0.0021459227467811 0
ADRA2B-201 ADRA2B P18089 Alpha-2B adrenergic receptor chr2 GO:0000165 Not Cancer Driver No 58 0.1288888888888889 136 15 0.0333333333333333 0
AR-201 AR P10275 Androgen receptor chrX GO:0000165 Census, Compendium Yes 116 0.1260869565217391 443 38 0.0413043478260869 144
ARAF-202 ARAF P10398 Serine/threonine-protein kinase A-Raf chrX GO:0000165 Census, Compendium Yes 61 0.1006600660066006 181 26 0.0429042904290429 0
ASH1L-201 ASH1L Q9NR48 Histone-lysine N-methyltransferase ASH1L chr1 GO:0000165 Not Cancer Driver No 298 0.1003704951162007 1863 184 0.0619737285281239 1
BANK1-201 BANK1 Q8NDB2 B-cell scaffold protein with ankyrin repeats chr4 GO:0000165 Not Cancer Driver No 109 0.1388535031847133 395 58 0.0738853503184713 0
BRAF-220 BRAF P15056 Serine/threonine-protein kinase B-raf chr7 GO:0000165 Census, Compendium Yes 755 0.9856396866840732 311 30 0.0391644908616188 35
BRAP-202 BRAP Q7Z569 BRCA1-associated protein chr12 GO:0000165 Not Cancer Driver No 54 0.0912162162162162 193 16 0.027027027027027 0
CAMKK2-207 CAMKK2 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 chr12 GO:0000165 Not Cancer Driver No 45 0.0765306122448979 283 28 0.0476190476190476 0
CAV1-201 CAV1 Q03135 Caveolin-1 chr7 GO:0000165 Not Cancer Driver No 23 0.1292134831460674 2 0 0.0 0
CAV3-201 CAV3 P56539 Caveolin-3 chr3 GO:0000165 Not Cancer Driver No 26 0.1721854304635761 0 0 0.0 24
CCL3-204 CCL3 P10147 C-C motif chemokine 3 chr17 GO:0000165 Not Cancer Driver No 13 0.1413043478260869 0 0 0.0 0
CCR5-201 CCR5 P51681 C-C chemokine receptor type 5 chr3 GO:0000165 Not Cancer Driver No 34 0.096590909090909 0 0 0.0 0
CD36-214 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0000165 Not Cancer Driver No 48 0.1016949152542373 12 3 0.0063559322033898 3
CTNNB1-201 CTNNB1 P35222 Catenin beta-1 chr3 GO:0000165 Census, Compendium Yes 363 0.4647887323943662 288 291 0.3725992317541613 11
DUSP5-201 DUSP5 Q16690 Dual specificity protein phosphatase 5 chr10 GO:0000165 Not Cancer Driver No 46 0.1197916666666666 36 3 0.0078125 0
DUSP6-201 DUSP6 Q16828 Dual specificity protein phosphatase 6 chr12 GO:0000165 Not Cancer Driver No 33 0.0866141732283464 39 3 0.0078740157480314 4
DUSP7-202 DUSP7 Q16829 Dual specificity protein phosphatase 7 chr3 GO:0000165 Not Cancer Driver No 31 0.0739856801909307 139 5 0.0119331742243436 0
DUSP9-201 DUSP9 Q99956 Dual specificity protein phosphatase 9 chrX GO:0000165 Not Cancer Driver No 33 0.0859375 109 12 0.03125 0
EGFR-201 EGFR P00533 Epidermal growth factor receptor chr7 GO:0000165 Census, Compendium Yes 346 0.2859504132231405 223 30 0.024793388429752 1
EPGN-202 EPGN Q6UW88 Epigen chr4 GO:0000165 Not Cancer Driver No 11 0.0714285714285714 0 0 0.0 0
FGF13-202 FGF13 Q92913 Fibroblast growth factor 13 chrX GO:0000165 Not Cancer Driver No 49 0.2 96 20 0.0816326530612244 3
FGF8-202 FGF8 P55075 Fibroblast growth factor 8 chr10 GO:0000165 Not Cancer Driver No 27 0.1158798283261802 79 8 0.0343347639484978 6
FGFR1-214 FGFR1 P11362 Fibroblast growth factor receptor 1 chr8 GO:0000165 Census, Compendium Yes 92 0.1119221411192214 231 26 0.0316301703163017 69
FGFR3-205 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 GO:0000165 Census, Compendium Yes 134 0.1662531017369727 241 18 0.0223325062034739 32
HRAS-201 HRAS P01112 GTPase HRas chr11 GO:0000165 Census, Compendium Yes 129 0.6825396825396826 16 2 0.0105820105820105 10
HSF1-204 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0000165 Not Cancer Driver No 49 0.0926275992438563 336 30 0.0567107750472589 0
IGFBP3-209 IGFBP3 P17936 Insulin-like growth factor-binding protein 3 chr7 GO:0000165 Not Cancer Driver No 35 0.120274914089347 104 20 0.0687285223367697 0
IGFBP4-201 IGFBP4 P22692 Insulin-like growth factor-binding protein 4 chr17 GO:0000165 Not Cancer Driver No 18 0.0697674418604651 106 12 0.0465116279069767 0
IL31RA-212 IL31RA Q8NI17 Interleukin-31 receptor subunit alpha chr5 GO:0000165 Not Cancer Driver No 85 0.1112565445026178 162 26 0.0340314136125654 1
ITPKB-203 ITPKB P27987 Inositol-trisphosphate 3-kinase B chr1 GO:0000165 Not Cancer Driver No 101 0.1067653276955602 727 81 0.0856236786469344 0
KRAS-201 KRAS P01116 GTPase KRas chr12 GO:0000165 Census, Compendium Yes 771 4.079365079365079 7 2 0.0105820105820105 22
LRRK2-201 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0000165 Not Cancer Driver No 402 0.1590819153146023 91 13 0.0051444400474871 20
MAP2K1-201 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 GO:0000165 Census, Compendium Yes 83 0.2111959287531806 96 22 0.0559796437659033 5
MAP2K2-201 MAP2K2 P36507 Dual specificity mitogen-activated protein kinase kinase 2 chr19 GO:0000165 Census Yes 45 0.1125 107 13 0.0325 3
MAP2K3-202 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 GO:0000165 Not Cancer Driver No 74 0.2132564841498559 76 19 0.0547550432276657 0
MAP2K4-201 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 GO:0000165 Census, Compendium Yes 72 0.1804511278195488 137 23 0.0576441102756892 0
MAP2K5-201 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 GO:0000165 Not Cancer Driver No 26 0.0580357142857142 85 6 0.0133928571428571 0
MAP2K6-206 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 GO:0000165 Not Cancer Driver No 28 0.0838323353293413 55 6 0.0179640718562874 0
MAP3K1-201 MAP3K1 Q13233 Mitogen-activated protein kinase kinase kinase 1 chr5 GO:0000165 Census, Compendium Yes 137 0.0906084656084656 829 43 0.0284391534391534 1
MAP3K11-201 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 GO:0000165 Not Cancer Driver No 84 0.0991735537190082 466 50 0.0590318772136954 0
MAP3K14-201 MAP3K14 Q99558 Mitogen-activated protein kinase kinase kinase 14 chr17 GO:0000165 Not Cancer Driver No 0 0.0 543 0 0.0 0
MAP3K15-201 MAP3K15 Q6ZN16 Mitogen-activated protein kinase kinase kinase 15 chrX GO:0000165 Not Cancer Driver No 142 0.1081492764661081 315 26 0.0198019801980198 0
MAP3K2-203 MAP3K2 Q9Y2U5 Mitogen-activated protein kinase kinase kinase 2 chr2 GO:0000165 Not Cancer Driver No 53 0.08562197092084 316 35 0.0565428109854604 0
MAP3K21-203 MAP3K21 Q5TCX8 Mitogen-activated protein kinase kinase kinase 21 chr1 GO:0000165 Not Cancer Driver No 146 0.1409266409266409 665 92 0.0888030888030888 0
MAP3K3-202 MAP3K3 Q99759 Mitogen-activated protein kinase kinase kinase 3 chr17 GO:0000165 Not Cancer Driver No 48 0.0766773162939297 356 27 0.0431309904153354 0
MAP3K4-204 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 GO:0000165 Not Cancer Driver No 183 0.1138059701492537 522 63 0.0391791044776119 0
MAP3K5-201 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0000165 Not Cancer Driver No 146 0.106259097525473 244 23 0.0167394468704512 0
MAP3K6-201 MAP3K6 O95382 Mitogen-activated protein kinase kinase kinase 6 chr1 GO:0000165 Not Cancer Driver No 72 0.0559006211180124 392 21 0.0163043478260869 0
MAP3K7-204 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0000165 Not Cancer Driver No 74 0.1221122112211221 333 42 0.0693069306930693 6
MAP3K8-201 MAP3K8 P41279 Mitogen-activated protein kinase kinase kinase 8 chr10 GO:0000165 Not Cancer Driver No 45 0.0963597430406852 109 6 0.012847965738758 0
MAP3K9-205 MAP3K9 P80192 Mitogen-activated protein kinase kinase kinase 9 chr14 GO:0000165 Not Cancer Driver No 134 0.1213768115942029 685 85 0.0769927536231884 0
MAP4K4-202 MAP4K4 O95819 Mitogen-activated protein kinase kinase kinase kinase 4 chr2 GO:0000165 Not Cancer Driver No 60 0.0484261501210653 648 29 0.0234059725585149 0
MAP4K5-210 MAP4K5 Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 chr14 GO:0000165 Not Cancer Driver No 54 0.0638297872340425 237 19 0.0224586288416075 0
MAPK12-201 MAPK12 P53778 Mitogen-activated protein kinase 12 chr22 GO:0000165 Not Cancer Driver No 27 0.0735694822888283 63 5 0.0136239782016348 0
MAPK15-201 MAPK15 Q8TD08 Mitogen-activated protein kinase 15 chr8 GO:0000165 Not Cancer Driver No 66 0.1213235294117647 236 32 0.0588235294117647 0
MAPK3-201 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0000165 Not Cancer Driver No 32 0.0844327176781002 49 3 0.0079155672823219 0
MAPK4-201 MAPK4 P31152 Mitogen-activated protein kinase 4 chr18 GO:0000165 Not Cancer Driver No 96 0.1635434412265758 226 39 0.0664395229982964 0
MAPK6-201 MAPK6 Q16659 Mitogen-activated protein kinase 6 chr15 GO:0000165 Not Cancer Driver No 52 0.0721220527045769 166 13 0.0180305131761442 0
MAPK7-204 MAPK7 Q13164 Mitogen-activated protein kinase 7 chr17 GO:0000165 Not Cancer Driver No 56 0.0686274509803921 490 31 0.0379901960784313 0
MAPKAPK2-202 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 GO:0000165 Not Cancer Driver No 27 0.0675 92 4 0.01 0
MAPKAPK3-208 MAPKAPK3 Q16644 MAP kinase-activated protein kinase 3 chr3 GO:0000165 Not Cancer Driver No 24 0.06282722513089 117 8 0.0209424083769633 1
MAPKAPK5-207 MAPKAPK5 Q8IW41 MAP kinase-activated protein kinase 5 chr12 GO:0000165 Not Cancer Driver No 38 0.080338266384778 101 6 0.0126849894291754 0
MBP-202 MBP P02686 Myelin basic protein chr18 GO:0000165 Not Cancer Driver No 26 0.0855263157894736 309 26 0.0855263157894736 0
MEF2A-215 MEF2A Q02078 Myocyte-specific enhancer factor 2A chr15 GO:0000165 Not Cancer Driver No 32 0.0631163708086785 450 31 0.0611439842209073 0
MEF2C-209 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:0000165 Not Cancer Driver No 54 0.1141649048625792 408 51 0.1078224101479915 2
MEN1-203 MEN1 O00255 Menin chr11 GO:0000165 Census, Compendium Yes 50 0.08130081300813 230 9 0.0146341463414634 80
MINK1-202 MINK1 Q8N4C8 Misshapen-like kinase 1 chr17 GO:0000165 Not Cancer Driver No 86 0.0645645645645645 742 42 0.0315315315315315 0
MOS-201 MOS P00540 Proto-oncogene serine/threonine-protein kinase mos chr8 GO:0000165 Not Cancer Driver No 69 0.1994219653179191 16 2 0.0057803468208092 0
MYC-206 MYC P01106 Myc proto-oncogene protein chr8 GO:0000165 Census, Compendium Yes 72 0.158590308370044 325 41 0.0903083700440528 0
NENF-201 NENF Q9UMX5 Neudesin chr1 GO:0000165 Not Cancer Driver No 12 0.0697674418604651 98 6 0.0348837209302325 0
NF1-202 NF1 P21359 Neurofibromin chr17 GO:0000165 Census, Compendium Yes 285 0.1003874603733709 406 36 0.0126805213103205 75
NF2-202 NF2 P35240 Merlin chr22 GO:0000165 Census, Compendium Yes 49 0.0823529411764705 252 18 0.0302521008403361 16
NLK-201 NLK Q9UBE8 Serine/threonine-protein kinase NLK chr17 GO:0000165 Not Cancer Driver No 42 0.079696394686907 152 15 0.0284629981024667 0
NPR2-201 NPR2 P20594 Atrial natriuretic peptide receptor 2 chr9 GO:0000165 Not Cancer Driver No 106 0.1012416427889207 91 9 0.0085959885386819 20
NRAS-201 NRAS P01111 GTPase NRas chr1 GO:0000165 Census, Compendium Yes 272 1.439153439153439 10 0 0.0 12
NRTN-201 NRTN Q99748 Neurturin chr19 GO:0000165 Not Cancer Driver No 6 0.0304568527918781 26 0 0.0 0
P2RX7-202 P2RX7 Q99572 P2X purinoceptor 7 chr12 GO:0000165 Not Cancer Driver No 37 0.0621848739495798 16 1 0.0016806722689075 0
PABPN1-201 PABPN1 Q86U42 Polyadenylate-binding protein 2 chr14 GO:0000165 Not Cancer Driver No 24 0.0784313725490196 241 15 0.0490196078431372 0
PAK1-202 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0000165 Not Cancer Driver No 36 0.0660550458715596 300 19 0.0348623853211009 2
PAK3-201 PAK3 O75914 Serine/threonine-protein kinase PAK 3 chrX GO:0000165 Not Cancer Driver No 95 0.1699463327370304 286 48 0.0858676207513416 2
PEA15-201 PEA15 Q15121 Astrocytic phosphoprotein PEA-15 chr1 GO:0000165 Not Cancer Driver No 7 0.0538461538461538 35 4 0.0307692307692307 0
PLVAP-201 PLVAP Q9BX97 Plasmalemma vesicle-associated protein chr19 GO:0000165 Not Cancer Driver No 78 0.1764705882352941 174 32 0.0723981900452488 1
POU4F2-201 POU4F2 Q12837 POU domain, class 4, transcription factor 2 chr4 GO:0000165 Not Cancer Driver No 96 0.2347188264058679 311 64 0.1564792176039119 0
PPM1L-205 PPM1L Q5SGD2 Protein phosphatase 1L chr3 GO:0000165 Not Cancer Driver No 46 0.1277777777777777 25 1 0.0027777777777777 0
PPP1CB-202 PPP1CB P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit chr2 GO:0000165 Not Cancer Driver No 33 0.1009174311926605 25 4 0.0122324159021406 4
PPP1CC-201 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 GO:0000165 Not Cancer Driver No 19 0.0588235294117647 23 3 0.0092879256965944 0
PPP5C-201 PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 GO:0000165 Not Cancer Driver No 58 0.1162324649298597 73 10 0.0200400801603206 0
PRKCE-201 PRKCE Q02156 Protein kinase C epsilon type chr2 GO:0000165 Not Cancer Driver No 80 0.1085481682496607 170 16 0.0217096336499321 0
PTK2B-201 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0000165 Not Cancer Driver No 117 0.1159563924677899 263 23 0.0227948463825569 0
PTPN3-202 PTPN3 P26045 Tyrosine-protein phosphatase non-receptor type 3 chr9 GO:0000165 Not Cancer Driver No 105 0.1150054764512595 214 24 0.0262869660460021 0
PTPN6-201 PTPN6 P29350 Tyrosine-protein phosphatase non-receptor type 6 chr12 GO:0000165 Census, Compendium Yes 52 0.0873949579831932 194 20 0.0336134453781512 0
PTPN7-220 PTPN7 P35236 Tyrosine-protein phosphatase non-receptor type 7 chr1 GO:0000165 Not Cancer Driver No 39 0.1083333333333333 165 17 0.0472222222222222 0
PTPRC-209 PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0000165 Census, Compendium Yes 257 0.1967840735068912 462 91 0.0696784073506891 0
RAF1-201 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 GO:0000165 Census, Compendium Yes 64 0.0987654320987654 169 30 0.0462962962962962 18
RAPGEF2-201 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0000165 Not Cancer Driver No 132 0.0880587058038692 805 72 0.048032021347565 0
RASGRP3-202 RASGRP3 Q8IV61 Ras guanyl-releasing protein 3 chr2 GO:0000165 Not Cancer Driver No 89 0.1289855072463768 148 14 0.0202898550724637 0
RBX1-201 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 GO:0000165 Not Cancer Driver No 9 0.0833333333333333 18 1 0.0092592592592592 0
RCE1-201 RCE1 Q9Y256 CAAX prenyl protease 2 chr11 GO:0000165 Not Cancer Driver No 26 0.0790273556231003 0 0 0.0 0
RET-202 RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 GO:0000165 Census, Compendium Yes 176 0.1579892280071813 108 11 0.0098743267504488 91
RHBDD3-201 RHBDD3 Q9Y3P4 Rhomboid domain-containing protein 3 chr22 GO:0000165 Not Cancer Driver No 19 0.0492227979274611 147 12 0.0310880829015544 0
RIPK1-201 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:0000165 Compendium Yes 59 0.0879284649776453 277 28 0.0417287630402384 1
RIT2-201 RIT2 Q99578 GTP-binding protein Rit2 chr18 GO:0000165 Not Cancer Driver No 61 0.2811059907834101 31 13 0.0599078341013824 0
SBK2-202 SBK2 P0C263 Serine/threonine-protein kinase SBK2 chr19 GO:0000165 Not Cancer Driver No 23 0.0660919540229885 73 1 0.0028735632183908 0
SCG2-201 SCG2 P13521 Secretogranin-2 chr2 GO:0000165 Not Cancer Driver No 95 0.1539708265802269 532 86 0.1393841166936791 0
SETX-201 SETX Q7Z333 Probable helicase senataxin chr9 GO:0000165 Not Cancer Driver No 213 0.0795666791184161 1248 89 0.0332461710870377 19
SHANK3-201 SHANK3 Q9BYB0 SH3 and multiple ankyrin repeat domains protein 3 chr22 GO:0000165 Not Cancer Driver No 98 0.0609831985065339 1257 68 0.0423148724331051 3
SMAD1-201 SMAD1 Q15797 Mothers against decapentaplegic homolog 1 chr4 GO:0000165 Not Cancer Driver No 39 0.0838709677419354 162 19 0.0408602150537634 0
SORBS3-201 SORBS3 O60504 Vinexin chr8 GO:0000165 Not Cancer Driver No 42 0.0625931445603576 578 36 0.0536512667660208 0
STUB1-201 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 GO:0000165 Not Cancer Driver No 29 0.0957095709570957 113 11 0.0363036303630363 11
TAOK3-201 TAOK3 Q9H2K8 Serine/threonine-protein kinase TAO3 chr12 GO:0000165 Not Cancer Driver No 95 0.1057906458797327 494 51 0.0567928730512249 0
TNIK-204 TNIK Q9UKE5 TRAF2 and NCK-interacting protein kinase chr3 GO:0000165 Not Cancer Driver No 126 0.0926470588235294 782 86 0.063235294117647 0
USP17L2-201 USP17L2 Q6R6M4 Ubiquitin carboxyl-terminal hydrolase 17 chr8 GO:0000165 Not Cancer Driver No 82 0.1547169811320754 208 48 0.090566037735849 0
YWHAE-201 YWHAE P62258 14-3-3 protein epsilon chr17 GO:0000165 Census Yes 24 0.0941176470588235 41 1 0.0039215686274509 0
ZDHHC9-201 ZDHHC9 Q9Y397 Palmitoyltransferase ZDHHC9 chrX GO:0000165 Not Cancer Driver No 34 0.0934065934065934 84 4 0.0109890109890109 2
ZFP36-203 ZFP36 P26651 mRNA decay activator protein ZFP36 chr19 GO:0000165 Not Cancer Driver No 30 0.0920245398773006 263 24 0.0736196319018405 0
ZFP36L1-202 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 GO:0000165 Compendium Yes 50 0.1479289940828402 212 26 0.0769230769230769 0