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Total number of protein in "GO:0000724" GO term:  99

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ANKLE1-202 ANKLE1 Q8NAG6 Ankyrin repeat and LEM domain-containing protein 1 chr19 GO:0000724 Not Cancer Driver No 49 0.0796747967479674 353 26 0.0422764227642276 0
AP5S1-205 AP5S1 Q9NUS5 AP-5 complex subunit sigma-1 chr20 GO:0000724 Not Cancer Driver No 24 0.12 57 7 0.035 0
AP5Z1-213 AP5Z1 O43299 AP-5 complex subunit zeta-1 chr7 GO:0000724 Not Cancer Driver No 70 0.0867410161090458 95 7 0.0086741016109045 0
ATM-229 ATM Q13315 Serine-protein kinase ATM chr11 GO:0000724 Census, Compendium Yes 358 0.1171465968586387 226 29 0.0094895287958115 41
AUNIP-201 AUNIP Q9H7T9 Aurora kinase A and ninein-interacting protein chr1 GO:0000724 Not Cancer Driver No 14 0.0392156862745098 341 13 0.0364145658263305 0
BLM-201 BLM P54132 RecQ-like DNA helicase BLM chr15 GO:0000724 Census Yes 112 0.0790402258292166 671 53 0.0374029640084686 9
BRCA1-203 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:0000724 Census, Compendium Yes 167 0.0896403650026838 1466 127 0.0681696188942565 34
BRCA2-201 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0000724 Census, Compendium Yes 310 0.0906963136337039 1545 152 0.0444704505558806 46
CHD4-206 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 GO:0000724 Census, Compendium Yes 312 0.1631799163179916 978 118 0.0617154811715481 6
EID3-201 EID3 Q8N140 EP300-interacting inhibitor of differentiation 3 chr12 GO:0000724 Not Cancer Driver No 18 0.054054054054054 56 2 0.006006006006006 0
EPC1-201 EPC1 Q9H2F5 Enhancer of polycomb homolog 1 chr10 GO:0000724 Not Cancer Driver No 84 0.1004784688995215 518 55 0.0657894736842105 0
ERCC4-201 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0000724 Census Yes 81 0.0884279475982532 226 19 0.0207423580786026 15
ERCC5-212 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 GO:0000724 Census Yes 115 0.096964586846543 819 78 0.0657672849915683 6
EXD2-214 EXD2 Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 chr14 GO:0000724 Not Cancer Driver No 47 0.0756843800322061 178 12 0.0193236714975845 0
FAN1-201 FAN1 Q9Y2M0 Fanconi-associated nuclease 1 chr15 GO:0000724 Not Cancer Driver No 86 0.0845624385447394 212 22 0.0216322517207472 4
FBH1-201 FBH1 Q8NFZ0 F-box DNA helicase 1 chr10 GO:0000724 Not Cancer Driver No 102 0.0977948226270374 192 28 0.0268456375838926 0
FEN1-201 FEN1 P39748 Flap endonuclease 1 chr11 GO:0000724 Census Yes 29 0.0763157894736842 111 13 0.0342105263157894 0
GEN1-202 GEN1 Q17RS7 Flap endonuclease GEN homolog 1 chr2 GO:0000724 Not Cancer Driver No 69 0.0759911894273127 340 28 0.0308370044052863 0
H2AX-202 H2AX P16104 Histone H2AX chr11 GO:0000724 Not Cancer Driver No 19 0.1328671328671328 68 8 0.0559440559440559 0
HELQ-201 HELQ Q8TDG4 Helicase POLQ-like chr4 GO:0000724 Not Cancer Driver No 86 0.0781108083560399 274 12 0.0108991825613079 0
HTATSF1-201 HTATSF1 O43719 HIV Tat-specific factor 1 chrX GO:0000724 Not Cancer Driver No 78 0.1033112582781456 575 57 0.0754966887417218 0
HUS1-201 HUS1 O60921 Checkpoint protein HUS1 chr7 GO:0000724 Not Cancer Driver No 19 0.0678571428571428 17 1 0.0035714285714285 0
HUS1B-201 HUS1B Q8NHY5 Checkpoint protein HUS1B chr6 GO:0000724 Not Cancer Driver No 35 0.1258992805755395 10 1 0.0035971223021582 0
INIP-203 INIP Q9NRY2 SOSS complex subunit C chr9 GO:0000724 Not Cancer Driver No 14 0.1346153846153846 79 9 0.0865384615384615 0
INO80-209 INO80 Q9ULG1 Chromatin-remodeling ATPase INO80 chr15 GO:0000724 Compendium Yes 137 0.0880462724935732 682 67 0.0430591259640102 0
INTS3-201 INTS3 Q68E01 Integrator complex subunit 3 chr1 GO:0000724 Not Cancer Driver No 91 0.0873320537428023 213 19 0.0182341650671785 0
KASH5-201 KASH5 Q8N6L0 Protein KASH5 chr19 GO:0000724 Not Cancer Driver No 73 0.1298932384341637 408 58 0.1032028469750889 0
KAT5-203 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 GO:0000724 Not Cancer Driver No 45 0.087719298245614 174 16 0.0311890838206627 3
KDM4D-201 KDM4D Q6B0I6 Lysine-specific demethylase 4D chr11 GO:0000724 Not Cancer Driver No 66 0.1261950286806883 215 24 0.0458891013384321 0
LIG3-202 LIG3 P49916 DNA ligase 3 chr17 GO:0000724 Not Cancer Driver No 92 0.0911793855302279 281 26 0.0257680872150644 4
MBTD1-204 MBTD1 Q05BQ5 MBT domain-containing protein 1 chr17 GO:0000724 Not Cancer Driver No 52 0.0828025477707006 119 6 0.0095541401273885 0
MCM8-205 MCM8 Q9UJA3 DNA helicase MCM8 chr20 GO:0000724 Not Cancer Driver No 61 0.0726190476190476 188 11 0.013095238095238 1
MCM9-209 MCM9 Q9NXL9 DNA helicase MCM9 chr6 GO:0000724 Not Cancer Driver No 39 0.0341207349081364 525 8 0.0069991251093613 0
MEIOB-202 MEIOB Q8N635 Meiosis-specific with OB domain-containing protein chr16 GO:0000724 Not Cancer Driver No 21 0.0475113122171945 21 0 0.0 1
MMS22L-213 MMS22L Q6ZRQ5 Protein MMS22-like chr6 GO:0000724 Not Cancer Driver No 131 0.1053901850362027 13 1 0.0008045052292839 0
MORF4L1-201 MORF4L1 Q9UBU8 Mortality factor 4-like protein 1 chr15 GO:0000724 Not Cancer Driver No 32 0.0883977900552486 163 11 0.0303867403314917 0
MRE11-201 MRE11 P49959 Double-strand break repair protein MRE11 chr11 GO:0000724 Not Cancer Driver No 61 0.0861581920903954 292 28 0.03954802259887 1
NABP1-205 NABP1 Q96AH0 SOSS complex subunit B2 chr2 GO:0000724 Not Cancer Driver No 20 0.0980392156862745 102 8 0.0392156862745098 0
NABP2-201 NABP2 Q9BQ15 SOSS complex subunit B1 chr12 GO:0000724 Not Cancer Driver No 22 0.1042654028436018 125 14 0.0663507109004739 0
NBN-201 NBN O60934 Nibrin chr8 GO:0000724 Census Yes 63 0.0835543766578249 420 45 0.059681697612732 1
NSMCE1-201 NSMCE1 Q8WV22 Non-structural maintenance of chromosomes element 1 homolog chr16 GO:0000724 Not Cancer Driver No 21 0.0789473684210526 31 2 0.0075187969924812 0
NSMCE2-201 NSMCE2 Q96MF7 E3 SUMO-protein ligase NSE2 chr8 GO:0000724 Not Cancer Driver No 18 0.0728744939271255 119 10 0.0404858299595141 0
NSMCE3-201 NSMCE3 Q96MG7 Non-structural maintenance of chromosomes element 3 homolog chr15 GO:0000724 Not Cancer Driver No 24 0.0789473684210526 129 6 0.0197368421052631 2
NSMCE4A-202 NSMCE4A Q9NXX6 Non-structural maintenance of chromosomes element 4 homolog A chr10 GO:0000724 Not Cancer Driver No 10 0.0259740259740259 201 2 0.0051948051948051 0
NUCKS1-201 NUCKS1 Q9H1E3 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 chr1 GO:0000724 Not Cancer Driver No 25 0.102880658436214 243 25 0.102880658436214 0
PALB2-201 PALB2 Q86YC2 Partner and localizer of BRCA2 chr16 GO:0000724 Census Yes 95 0.0801011804384485 772 56 0.0472175379426644 1
POGZ-201 POGZ Q7Z3K3 Pogo transposable element with ZNF domain chr1 GO:0000724 Not Cancer Driver No 106 0.075177304964539 747 50 0.0354609929078014 1
POLL-203 POLL Q9UGP5 DNA polymerase lambda chr10 GO:0000724 Not Cancer Driver No 57 0.0991304347826086 215 13 0.0226086956521739 0
POLN-210 POLN Q7Z5Q5 DNA polymerase nu chr4 GO:0000724 Not Cancer Driver No 87 0.0966666666666666 247 17 0.0188888888888888 0
PPP4C-201 PPP4C P60510 Serine/threonine-protein phosphatase 4 catalytic subunit chr16 GO:0000724 Not Cancer Driver No 27 0.0879478827361563 0 0 0.0 0
PSMD14-201 PSMD14 O00487 26S proteasome non-ATPase regulatory subunit 14 chr2 GO:0000724 Not Cancer Driver No 14 0.0451612903225806 68 3 0.0096774193548387 0
RAD51-201 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0000724 Not Cancer Driver No 27 0.079646017699115 48 3 0.0088495575221238 3
RAD51AP1-201 RAD51AP1 Q96B01 RAD51-associated protein 1 chr12 GO:0000724 Not Cancer Driver No 37 0.1051136363636363 337 35 0.0994318181818181 0
RAD51B-209 RAD51B O15315 DNA repair protein RAD51 homolog 2 chr14 GO:0000724 Census Yes 32 0.0833333333333333 12 0 0.0 0
RAD51C-201 RAD51C O43502 DNA repair protein RAD51 homolog 3 chr17 GO:0000724 Not Cancer Driver No 39 0.1037234042553191 18 2 0.0053191489361702 6
RAD51D-202 RAD51D O75771 DNA repair protein RAD51 homolog 4 chr17 GO:0000724 Not Cancer Driver No 20 0.0609756097560975 50 8 0.024390243902439 0
RAD52-202 RAD52 P43351 DNA repair protein RAD52 homolog chr12 GO:0000724 Not Cancer Driver No 30 0.0717703349282296 252 24 0.0574162679425837 0
RAD54B-202 RAD54B Q9Y620 DNA repair and recombination protein RAD54B chr8 GO:0000724 Not Cancer Driver No 73 0.0802197802197802 122 9 0.0098901098901098 0
RBBP8-201 RBBP8 Q99708 DNA endonuclease RBBP8 chr18 GO:0000724 Not Cancer Driver No 72 0.0802675585284281 751 54 0.060200668896321 1
REC8-209 REC8 O95072 Meiotic recombination protein REC8 homolog chr14 GO:0000724 Not Cancer Driver No 45 0.0822669104204753 245 18 0.0329067641681901 0
RECQL-204 RECQL P46063 ATP-dependent DNA helicase Q1 chr12 GO:0000724 Not Cancer Driver No 50 0.0770416024653312 91 1 0.0015408320493066 0
RECQL4-209 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 GO:0000724 Census, Compendium Yes 105 0.0869205298013245 612 54 0.0447019867549668 1
RECQL5-201 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 GO:0000724 Not Cancer Driver No 101 0.1019172552976791 499 57 0.0575176589303733 0
REV3L-202 REV3L O60673 DNA polymerase zeta catalytic subunit chr6 GO:0000724 Not Cancer Driver No 261 0.0833865814696485 1671 135 0.0431309904153354 0
RFWD3-201 RFWD3 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 chr16 GO:0000724 Census Yes 59 0.0762273901808785 319 26 0.0335917312661498 1
RMI1-202 RMI1 Q9H9A7 RecQ-mediated genome instability protein 1 chr9 GO:0000724 Not Cancer Driver No 38 0.0608 243 16 0.0256 0
RMI2-201 RMI2 Q96E14 RecQ-mediated genome instability protein 2 chr16 GO:0000724 Census Yes 6 0.0408163265306122 88 3 0.0204081632653061 0
RNF138-202 RNF138 Q8WVD3 E3 ubiquitin-protein ligase RNF138 chr18 GO:0000724 Not Cancer Driver No 32 0.1306122448979592 35 5 0.0204081632653061 0
RNF169-201 RNF169 Q8NCN4 E3 ubiquitin-protein ligase RNF169 chr11 GO:0000724 Not Cancer Driver No 41 0.057909604519774 638 40 0.0564971751412429 0
RPA1-201 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 GO:0000724 Not Cancer Driver No 45 0.073051948051948 98 7 0.0113636363636363 1
RPA2-203 RPA2 P15927 Replication protein A 32 kDa subunit chr1 GO:0000724 Not Cancer Driver No 20 0.074074074074074 117 12 0.0444444444444444 0
RPA3-201 RPA3 P35244 Replication protein A 14 kDa subunit chr7 GO:0000724 Not Cancer Driver No 10 0.0826446280991735 4 1 0.0082644628099173 0
RPA4-201 RPA4 Q13156 Replication protein A 30 kDa subunit chrX GO:0000724 Not Cancer Driver No 56 0.21455938697318 59 10 0.0383141762452107 0
SAMHD1-221 SAMHD1 Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 chr20 GO:0000724 Not Cancer Driver No 80 0.1277955271565495 91 9 0.0143769968051118 12
SEM1-202 SEM1 Q6ZVN7 Putative protein SEM1, isoform 2 chr7 GO:0000724 Not Cancer Driver No 2 0.015625 52 1 0.0078125 0
SFPQ-201 SFPQ P23246 Splicing factor, proline- and glutamine-rich chr1 GO:0000724 Census Yes 37 0.0523338048090523 596 27 0.0381895332390381 0
SFR1-201 SFR1 Q86XK3 Swi5-dependent recombination DNA repair protein 1 homolog chr10 GO:0000724 Not Cancer Driver No 12 0.0489795918367346 109 8 0.0326530612244898 0
SLF1-201 SLF1 Q9BQI6 SMC5-SMC6 complex localization factor protein 1 chr5 GO:0000724 Not Cancer Driver No 70 0.0661625708884688 167 8 0.0075614366729678 0
SLF2-201 SLF2 Q8IX21 SMC5-SMC6 complex localization factor protein 2 chr10 GO:0000724 Not Cancer Driver No 83 0.0707587382779198 726 58 0.0494458653026428 1
SLX1A-201 SLX1B Q9BQ83 Structure-specific endonuclease subunit SLX1 chr16 GO:0000724 Not Cancer Driver No 3 0.0109090909090909 80 0 0.0 0
SLX1B-201 SLX1B Q9BQ83 Structure-specific endonuclease subunit SLX1 chr16 GO:0000724 Not Cancer Driver No 3 0.0109090909090909 80 0 0.0 0
SLX4-201 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 GO:0000724 Not Cancer Driver No 201 0.1095965103598691 1586 175 0.0954198473282442 0
SMC5-201 SMC5 Q8IY18 Structural maintenance of chromosomes protein 5 chr9 GO:0000724 Not Cancer Driver No 94 0.0853769300635785 381 35 0.0317892824704813 1
SMC6-207 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0000724 Not Cancer Driver No 95 0.0870760769935838 459 43 0.0394133822181484 0
SPIDR-201 SPIDR Q14159 DNA repair-scaffolding protein chr8 GO:0000724 Not Cancer Driver No 84 0.0918032786885245 330 17 0.0185792349726775 0
SWSAP1-201 SWSAP1 Q6NVH7 ATPase SWSAP1 chr19 GO:0000724 Not Cancer Driver No 15 0.0655021834061135 106 7 0.0305676855895196 0
TONSL-201 TONSL Q96HA7 Tonsoku-like protein chr8 GO:0000724 Not Cancer Driver No 127 0.0921625544267053 550 53 0.0384615384615384 8
TOP3A-201 TOP3A Q13472 DNA topoisomerase 3-alpha chr17 GO:0000724 Not Cancer Driver No 79 0.0789210789210789 293 28 0.0279720279720279 2
TOPBP1-201 TOPBP1 Q92547 DNA topoisomerase 2-binding protein 1 chr3 GO:0000724 Not Cancer Driver No 121 0.0795006570302234 579 43 0.0282522996057818 0
UBE2N-201 UBE2N P61088 Ubiquitin-conjugating enzyme E2 N chr12 GO:0000724 Not Cancer Driver No 19 0.125 24 1 0.006578947368421 0
UHRF1-208 UHRF1 Q96T88 E3 ubiquitin-protein ligase UHRF1 chr19 GO:0000724 Not Cancer Driver No 0 0.0 353 0 0.0 0
WDR48-201 WDR48 Q8TAF3 WD repeat-containing protein 48 chr3 GO:0000724 Not Cancer Driver No 48 0.0709010339734121 125 16 0.0236336779911373 0
WRN-201 WRN Q14191 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN chr8 GO:0000724 Census, Compendium Yes 133 0.092877094972067 374 29 0.0202513966480446 2
XRCC2-201 XRCC2 O43543 DNA repair protein XRCC2 chr7 GO:0000724 Not Cancer Driver No 27 0.0964285714285714 9 0 0.0 2
XRCC3-211 XRCC3 O43542 DNA repair protein XRCC3 chr14 GO:0000724 Not Cancer Driver No 21 0.0606936416184971 35 2 0.0057803468208092 1
YY1-201 YY1 P25490 Transcriptional repressor protein YY1 chr14 GO:0000724 Not Cancer Driver No 29 0.0700483091787439 337 21 0.0507246376811594 2
ZFYVE26-201 ZFYVE26 Q68DK2 Zinc finger FYVE domain-containing protein 26 chr14 GO:0000724 Not Cancer Driver No 219 0.0862544308782985 568 58 0.0228436392280425 0
ZMYND8-202 ZMYND8 Q9ULU4 MYND-type zinc finger-containing chromatin reader ZMYND8 chr20 GO:0000724 Not Cancer Driver No 125 0.1053962900505902 833 84 0.0708263069139966 8
ZSWIM7-201 ZSWIM7 Q19AV6 Zinc finger SWIM domain-containing protein 7 chr17 GO:0000724 Not Cancer Driver No 7 0.05 0 0 0.0 0