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Total number of protein in "GO:0004222" GO term:  110

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACE-202 ACE P12821 Angiotensin-converting enzyme chr17 GO:0004222 Not Cancer Driver No 152 0.116385911179173 87 5 0.0038284839203675 0
ADAM10-201 ADAM10 O14672 Disintegrin and metalloproteinase domain-containing protein 10 chr15 GO:0004222 Not Cancer Driver No 73 0.0975935828877005 156 18 0.0240641711229946 4
ADAM11-201 ADAM11 O75078 Disintegrin and metalloproteinase domain-containing protein 11 chr17 GO:0004222 Not Cancer Driver No 84 0.1092327698309492 163 15 0.0195058517555266 0
ADAM12-202 ADAM12 O43184 Disintegrin and metalloproteinase domain-containing protein 12 chr10 GO:0004222 Not Cancer Driver No 123 0.1353135313531353 206 33 0.0363036303630363 0
ADAM15-203 ADAM15 Q13444 Disintegrin and metalloproteinase domain-containing protein 15 chr1 GO:0004222 Not Cancer Driver No 76 0.0880648899188876 215 23 0.0266512166859791 0
ADAM17-201 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0004222 Not Cancer Driver No 63 0.0764563106796116 182 17 0.020631067961165 0
ADAM18-201 ADAM18 Q9Y3Q7 Disintegrin and metalloproteinase domain-containing protein 18 chr8 GO:0004222 Not Cancer Driver No 184 0.2489851150202977 4 1 0.0013531799729364 0
ADAM19-203 ADAM19 Q9H013 Disintegrin and metalloproteinase domain-containing protein 19 chr5 GO:0004222 Not Cancer Driver No 144 0.1507853403141361 372 61 0.0638743455497382 0
ADAM2-201 ADAM2 Q99965 Disintegrin and metalloproteinase domain-containing protein 2 chr8 GO:0004222 Not Cancer Driver No 159 0.2163265306122449 18 0 0.0 0
ADAM20-201 ADAM20 O43506 Disintegrin and metalloproteinase domain-containing protein 20 chr14 GO:0004222 Not Cancer Driver No 69 0.0950413223140495 22 3 0.0041322314049586 0
ADAM21-201 ADAM21 Q9UKJ8 Disintegrin and metalloproteinase domain-containing protein 21 chr14 GO:0004222 Not Cancer Driver No 117 0.1620498614958448 4 0 0.0 0
ADAM22-201 ADAM22 Q9P0K1 Disintegrin and metalloproteinase domain-containing protein 22 chr7 GO:0004222 Not Cancer Driver No 132 0.1456953642384106 222 15 0.0165562913907284 0
ADAM23-201 ADAM23 O75077 Disintegrin and metalloproteinase domain-containing protein 23 chr2 GO:0004222 Not Cancer Driver No 133 0.1598557692307692 162 20 0.0240384615384615 0
ADAM28-201 ADAM28 Q9UKQ2 Disintegrin and metalloproteinase domain-containing protein 28 chr8 GO:0004222 Not Cancer Driver No 145 0.1870967741935484 124 18 0.0232258064516129 0
ADAM29-201 ADAM29 Q9UKF5 Disintegrin and metalloproteinase domain-containing protein 29 chr4 GO:0004222 Not Cancer Driver No 180 0.2195121951219512 124 10 0.0121951219512195 0
ADAM30-201 ADAM30 Q9UKF2 Disintegrin and metalloproteinase domain-containing protein 30 chr1 GO:0004222 Not Cancer Driver No 101 0.1278481012658227 73 12 0.0151898734177215 0
ADAM32-201 ADAM32 Q8TC27 Disintegrin and metalloproteinase domain-containing protein 32 chr8 GO:0004222 Not Cancer Driver No 92 0.1168996188055908 88 10 0.0127064803049555 0
ADAM33-202 ADAM33 Q9BZ11 Disintegrin and metalloproteinase domain-containing protein 33 chr20 GO:0004222 Not Cancer Driver No 81 0.0996309963099631 169 23 0.028290282902829 0
ADAM7-201 ADAM7 Q9H2U9 Disintegrin and metalloproteinase domain-containing protein 7 chr8 GO:0004222 Not Cancer Driver No 190 0.2519893899204244 55 17 0.0225464190981432 0
ADAM8-202 ADAM8 P78325 Disintegrin and metalloproteinase domain-containing protein 8 chr10 GO:0004222 Not Cancer Driver No 62 0.0752427184466019 232 12 0.0145631067961165 0
ADAM9-209 ADAM9 Q13443 Disintegrin and metalloproteinase domain-containing protein 9 chr8 GO:0004222 Not Cancer Driver No 59 0.072039072039072 130 7 0.0085470085470085 0
ADAMDEC1-201 ADAMDEC1 O15204 ADAM DEC1 chr8 GO:0004222 Not Cancer Driver No 92 0.1957446808510638 107 25 0.0531914893617021 0
ADAMTS1-201 ADAMTS1 Q9UHI8 A disintegrin and metalloproteinase with thrombospondin motifs 1 chr21 GO:0004222 Not Cancer Driver No 101 0.1044467425025853 275 26 0.0268872802481902 0
ADAMTS10-211 ADAMTS10 Q9H324 A disintegrin and metalloproteinase with thrombospondin motifs 10 chr19 GO:0004222 Not Cancer Driver No 153 0.1387126019945603 155 30 0.027198549410698 1
ADAMTS12-203 ADAMTS12 P58397 A disintegrin and metalloproteinase with thrombospondin motifs 12 chr5 GO:0004222 Not Cancer Driver No 433 0.2716436637390213 375 112 0.0702634880803011 0
ADAMTS13-206 ADAMTS13 Q76LX8 A disintegrin and metalloproteinase with thrombospondin motifs 13 chr9 GO:0004222 Not Cancer Driver No 138 0.0967063770147161 286 26 0.0182200420462508 42
ADAMTS14-201 ADAMTS14 Q8WXS8 A disintegrin and metalloproteinase with thrombospondin motifs 14 chr10 GO:0004222 Not Cancer Driver No 168 0.1373671300081766 337 46 0.0376124284546197 0
ADAMTS15-201 ADAMTS15 Q8TE58 A disintegrin and metalloproteinase with thrombospondin motifs 15 chr11 GO:0004222 Not Cancer Driver No 100 0.1052631578947368 141 17 0.0178947368421052 0
ADAMTS16-201 ADAMTS16 Q8TE57 A disintegrin and metalloproteinase with thrombospondin motifs 16 chr5 GO:0004222 Not Cancer Driver No 309 0.2524509803921568 179 46 0.0375816993464052 0
ADAMTS17-201 ADAMTS17 Q8TE56 A disintegrin and metalloproteinase with thrombospondin motifs 17 chr15 GO:0004222 Not Cancer Driver No 149 0.1360730593607305 187 31 0.028310502283105 0
ADAMTS18-201 ADAMTS18 Q8TE60 A disintegrin and metalloproteinase with thrombospondin motifs 18 chr16 GO:0004222 Not Cancer Driver No 300 0.2457002457002457 143 46 0.0376740376740376 2
ADAMTS19-201 ADAMTS19 Q8TE59 A disintegrin and metalloproteinase with thrombospondin motifs 19 chr5 GO:0004222 Not Cancer Driver No 235 0.1937345424567188 241 18 0.0148392415498763 0
ADAMTS2-201 ADAMTS2 O95450 A disintegrin and metalloproteinase with thrombospondin motifs 2 chr5 GO:0004222 Not Cancer Driver No 237 0.1957060280759702 306 67 0.0553261767134599 0
ADAMTS20-201 ADAMTS20 P59510 A disintegrin and metalloproteinase with thrombospondin motifs 20 chr12 GO:0004222 Not Cancer Driver No 413 0.2162303664921466 120 25 0.013089005235602 0
ADAMTS3-201 ADAMTS3 O15072 A disintegrin and metalloproteinase with thrombospondin motifs 3 chr4 GO:0004222 Not Cancer Driver No 184 0.1526970954356846 295 53 0.0439834024896265 3
ADAMTS4-202 ADAMTS4 O75173 A disintegrin and metalloproteinase with thrombospondin motifs 4 chr1 GO:0004222 Not Cancer Driver No 102 0.1218637992831541 160 19 0.022700119474313 0
ADAMTS5-201 ADAMTS5 Q9UNA0 A disintegrin and metalloproteinase with thrombospondin motifs 5 chr21 GO:0004222 Not Cancer Driver No 173 0.1860215053763441 148 23 0.0247311827956989 0
ADAMTS6-203 ADAMTS6 Q9UKP5 A disintegrin and metalloproteinase with thrombospondin motifs 6 chr5 GO:0004222 Not Cancer Driver No 100 0.0895255147717099 75 7 0.0062667860340196 0
ADAMTS7-201 ADAMTS7 Q9UKP4 A disintegrin and metalloproteinase with thrombospondin motifs 7 chr15 GO:0004222 Not Cancer Driver No 186 0.1103202846975089 653 83 0.0492289442467378 0
ADAMTS8-201 ADAMTS8 Q9UP79 A disintegrin and metalloproteinase with thrombospondin motifs 8 chr11 GO:0004222 Not Cancer Driver No 89 0.1001124859392575 207 15 0.0168728908886389 0
ADAMTS9-210 ADAMTS9 Q9P2N4 A disintegrin and metalloproteinase with thrombospondin motifs 9 chr3 GO:0004222 Not Cancer Driver No 214 0.110594315245478 237 30 0.0155038759689922 0
ADAMTSL2-204 ADAMTSL2 Q86TH1 ADAMTS-like protein 2 chr9 GO:0004222 Not Cancer Driver No 32 0.0336487907465825 238 5 0.0052576235541535 14
AFG3L2-201 AFG3L2 Q9Y4W6 AFG3-like protein 2 chr18 GO:0004222 Not Cancer Driver No 38 0.0476787954830614 162 5 0.0062735257214554 17
ASTL-201 ASTL Q6HA08 Astacin-like metalloendopeptidase chr2 GO:0004222 Not Cancer Driver No 79 0.1832946635730858 180 38 0.0881670533642691 0
ATP23-201 ATP23 Q9Y6H3 Mitochondrial inner membrane protease ATP23 homolog chr12 GO:0004222 Not Cancer Driver No 16 0.065040650406504 25 4 0.016260162601626 0
BMP1-202 BMP1 P13497 Bone morphogenetic protein 1 chr8 GO:0004222 Not Cancer Driver No 93 0.0943204868154158 154 23 0.0233265720081135 3
CIROP-201 CIROP A0A1B0GTW7 Ciliated left-right organizer metallopeptidase chr14 GO:0004222 Not Cancer Driver No 0 0.0 161 0 0.0 0
CLCA1-202 CLCA1 A8K7I4 Calcium-activated chloride channel regulator 1 chr1 GO:0004222 Not Cancer Driver No 100 0.1094091903719912 213 13 0.0142231947483588 0
CLCA2-201 CLCA2 Q9UQC9 Calcium-activated chloride channel regulator 2 chr1 GO:0004222 Not Cancer Driver No 93 0.0986214209968186 222 23 0.024390243902439 0
CLCA4-201 CLCA4 Q14CN2 Calcium-activated chloride channel regulator 4 chr1 GO:0004222 Not Cancer Driver No 136 0.147986942328618 193 25 0.0272034820457018 0
ECE1-203 ECE1 P42892 Endothelin-converting enzyme 1 chr1 GO:0004222 Not Cancer Driver No 95 0.1233766233766233 99 21 0.0272727272727272 1
ECE2-201 ECE2 P0DPD6 Endothelin-converting enzyme 2 chr3 GO:0004222 Not Cancer Driver No 120 0.1479654747225647 150 22 0.0271270036991368 0
ECEL1-201 ECEL1 O95672 Endothelin-converting enzyme-like 1 chr2 GO:0004222 Not Cancer Driver No 95 0.1225806451612903 22 2 0.0025806451612903 4
EEF1AKMT4-ECE2-201 EEF1AKMT4-ECE2 P0DPD8 EEF1AKMT4-ECE2 readthrough transcript protein chr3 GO:0004222 Not Cancer Driver No 137 0.1551528878822197 100 25 0.0283125707814269 0
IDE-201 IDE P14735 Insulin-degrading enzyme chr10 GO:0004222 Not Cancer Driver No 65 0.0637880274779195 96 6 0.0058881256133464 0
KEL-201 KEL P23276 Kell blood group glycoprotein chr7 GO:0004222 Compendium Yes 189 0.2581967213114754 117 37 0.0505464480874316 0
KLK7-205 KLK7 P49862 Kallikrein-7 chr19 GO:0004222 Not Cancer Driver No 33 0.1304347826086956 38 5 0.0197628458498023 0
LMLN-204 LMLN Q96KR4 Leishmanolysin-like peptidase chr3 GO:0004222 Not Cancer Driver No 43 0.0628654970760233 46 3 0.0043859649122807 0
MBTPS2-202 MBTPS2 O43462 Membrane-bound transcription factor site-2 protease chrX GO:0004222 Not Cancer Driver No 41 0.0789980732177264 16 3 0.0057803468208092 9
MEP1A-201 MEP1A Q16819 Meprin A subunit alpha chr6 GO:0004222 Not Cancer Driver No 111 0.1487935656836461 143 12 0.0160857908847185 0
MEP1B-201 MEP1B Q16820 Meprin A subunit beta chr18 GO:0004222 Not Cancer Driver No 72 0.1027104136947218 63 9 0.0128388017118402 0
MIPEP-201 MIPEP Q99797 Mitochondrial intermediate peptidase chr13 GO:0004222 Not Cancer Driver No 57 0.0799438990182328 40 1 0.0014025245441795 3
MME-201 MME P08473 Neprilysin chr3 GO:0004222 Not Cancer Driver No 156 0.208 40 17 0.0226666666666666 4
MMEL1-201 MMEL1 Q495T6 Membrane metallo-endopeptidase-like 1 chr1 GO:0004222 Not Cancer Driver No 102 0.1309370988446726 46 5 0.0064184852374839 0
MMP1-201 MMP1 P03956 Interstitial collagenase chr11 GO:0004222 Not Cancer Driver No 65 0.138592750533049 114 16 0.0341151385927505 0
MMP10-201 MMP10 P09238 Stromelysin-2 chr11 GO:0004222 Not Cancer Driver No 72 0.1512605042016806 38 8 0.0168067226890756 0
MMP11-201 MMP11 P24347 Stromelysin-3 chr22 GO:0004222 Not Cancer Driver No 47 0.096311475409836 122 13 0.026639344262295 0
MMP12-201 MMP12 P39900 Macrophage metalloelastase chr11 GO:0004222 Not Cancer Driver No 0 0.0 29 0 0.0 0
MMP13-201 MMP13 P45452 Collagenase 3 chr11 GO:0004222 Not Cancer Driver No 87 0.1847133757961783 59 12 0.0254777070063694 5
MMP14-201 MMP14 P50281 Matrix metalloproteinase-14 chr14 GO:0004222 Not Cancer Driver No 50 0.0859106529209622 120 6 0.0103092783505154 1
MMP15-201 MMP15 P51511 Matrix metalloproteinase-15 chr16 GO:0004222 Not Cancer Driver No 63 0.0941704035874439 206 19 0.0284005979073243 0
MMP16-201 MMP16 P51512 Matrix metalloproteinase-16 chr8 GO:0004222 Not Cancer Driver No 196 0.3228995057660626 168 52 0.085667215815486 0
MMP17-201 MMP17 Q9ULZ9 Matrix metalloproteinase-17 chr12 GO:0004222 Not Cancer Driver No 76 0.1260364842454394 244 23 0.0381426202321724 0
MMP19-201 MMP19 Q99542 Matrix metalloproteinase-19 chr12 GO:0004222 Not Cancer Driver No 61 0.1200787401574803 98 13 0.0255905511811023 0
MMP2-201 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0004222 Not Cancer Driver No 101 0.153030303030303 29 5 0.0075757575757575 2
MMP20-201 MMP20 O60882 Matrix metalloproteinase-20 chr11 GO:0004222 Not Cancer Driver No 58 0.1200828157349896 70 7 0.0144927536231884 0
MMP21-201 MMP21 Q8N119 Matrix metalloproteinase-21 chr10 GO:0004222 Not Cancer Driver No 53 0.0931458699472759 147 11 0.0193321616871704 8
MMP23B-201 MMP23B O75900 Matrix metalloproteinase-23 chr1 GO:0004222 Not Cancer Driver No 2 0.0051282051282051 35 0 0.0 0
MMP24-201 MMP24 Q9Y5R2 Matrix metalloproteinase-24 chr20 GO:0004222 Not Cancer Driver No 56 0.0868217054263565 163 16 0.0248062015503875 0
MMP25-201 MMP25 Q9NPA2 Matrix metalloproteinase-25 chr16 GO:0004222 Not Cancer Driver No 41 0.0729537366548042 245 16 0.0284697508896797 0
MMP26-202 MMP26 Q9NRE1 Matrix metalloproteinase-26 chr11 GO:0004222 Not Cancer Driver No 58 0.2222222222222222 19 8 0.0306513409961685 0
MMP27-201 MMP27 Q9H306 Matrix metalloproteinase-27 chr11 GO:0004222 Not Cancer Driver No 77 0.1500974658869395 36 9 0.0175438596491228 0
MMP28-201 MMP28 Q9H239 Matrix metalloproteinase-28 chr17 GO:0004222 Not Cancer Driver No 12 0.023076923076923 54 3 0.0057692307692307 0
MMP3-201 MMP3 P08254 Stromelysin-1 chr11 GO:0004222 Not Cancer Driver No 74 0.1551362683438155 66 13 0.0272536687631027 0
MMP7-201 MMP7 P09237 Matrilysin chr11 GO:0004222 Not Cancer Driver No 27 0.1011235955056179 70 2 0.0074906367041198 0
MMP8-201 MMP8 P22894 Neutrophil collagenase chr11 GO:0004222 Not Cancer Driver No 62 0.1327623126338329 117 16 0.0342612419700214 0
MMP9-201 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0004222 Not Cancer Driver No 106 0.1499292786421499 124 24 0.0339462517680339 0
NLN-201 NLN Q9BYT8 Neurolysin, mitochondrial chr5 GO:0004222 Not Cancer Driver No 60 0.0852272727272727 25 3 0.0042613636363636 0
NRDC-201 NRDC O43847 Nardilysin chr1 GO:0004222 Not Cancer Driver No 117 0.101650738488271 253 22 0.0191138140747176 0
OMA1-201 OMA1 Q96E52 Metalloendopeptidase OMA1, mitochondrial chr1 GO:0004222 Not Cancer Driver No 39 0.0744274809160305 35 3 0.0057251908396946 0
PAPPA-201 PAPPA Q13219 Pappalysin-1 chr9 GO:0004222 Not Cancer Driver No 294 0.1807006760909649 239 36 0.0221266133988936 0
PAPPA2-202 PAPPA2 Q9BXP8 Pappalysin-2 chr1 GO:0004222 Not Cancer Driver No 629 0.3512004466778336 371 120 0.067001675041876 1
PHEX-201 PHEX P78562 Phosphate-regulating neutral endopeptidase PHEX chrX GO:0004222 Not Cancer Driver No 100 0.1335113484646194 56 4 0.0053404539385847 27
PITRM1-201 PITRM1 Q5JRX3 Presequence protease, mitochondrial chr10 GO:0004222 Not Cancer Driver No 70 0.0675024108003857 222 16 0.0154291224686595 2
PMPCA-201 PMPCA Q10713 Mitochondrial-processing peptidase subunit alpha chr9 GO:0004222 Not Cancer Driver No 48 0.0914285714285714 23 3 0.0057142857142857 4
PMPCB-201 PMPCB O75439 Mitochondrial-processing peptidase subunit beta chr7 GO:0004222 Not Cancer Driver No 36 0.0736196319018405 22 2 0.0040899795501022 4
PRSS2-201 PRSS2 P07478 Trypsin-2 chr7 GO:0004222 Not Cancer Driver No 0 0.0 9 0 0.0 0
RCE1-201 RCE1 Q9Y256 CAAX prenyl protease 2 chr11 GO:0004222 Not Cancer Driver No 26 0.0790273556231003 0 0 0.0 0
SPG7-268 SPG7 Q9UQ90 Paraplegin chr16 GO:0004222 Not Cancer Driver No 76 0.0955974842767295 184 23 0.0289308176100628 4
SPRTN-202 SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 GO:0004222 Not Cancer Driver No 53 0.1083844580777096 254 26 0.0531697341513292 1
THOP1-201 THOP1 P52888 Thimet oligopeptidase chr19 GO:0004222 Not Cancer Driver No 68 0.0986937590711175 92 11 0.0159651669085631 0
TLL1-201 TLL1 O43897 Tolloid-like protein 1 chr4 GO:0004222 Compendium Yes 268 0.2645607107601184 139 51 0.050345508390918 3
TLL2-201 TLL2 Q9Y6L7 Tolloid-like protein 2 chr10 GO:0004222 Not Cancer Driver No 138 0.1359605911330049 176 26 0.025615763546798 0
TMPRSS6-208 TMPRSS6 Q8IU80 Transmembrane protease serine 6 chr22 GO:0004222 Not Cancer Driver No 100 0.1246882793017456 40 5 0.0062344139650872 23
TRABD2A-203 TRABD2A Q86V40 Metalloprotease TIKI1 chr2 GO:0004222 Not Cancer Driver No 65 0.1287128712871287 133 29 0.0574257425742574 0
TRABD2B-202 TRABD2B A6NFA1 Metalloprotease TIKI2 chr1 GO:0004222 Not Cancer Driver No 0 0.0 213 0 0.0 0
UQCRC2-201 UQCRC2 P22695 Cytochrome b-c1 complex subunit 2, mitochondrial chr16 GO:0004222 Not Cancer Driver No 31 0.0684326710816777 48 5 0.0110375275938189 1
YBEY-206 YBEY P58557 Endoribonuclease YbeY chr21 GO:0004222 Not Cancer Driver No 13 0.0778443113772455 9 1 0.0059880239520958 0
YME1L1-201 YME1L1 Q96TA2 ATP-dependent zinc metalloprotease YME1L1 chr10 GO:0004222 Not Cancer Driver No 80 0.1034928848641656 136 10 0.0129366106080207 1
ZMPSTE24-201 ZMPSTE24 O75844 CAAX prenyl protease 1 homolog chr1 GO:0004222 Not Cancer Driver No 46 0.0968421052631579 23 0 0.0 3