Total number of protein in "GO:0006260" GO term: 93
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADRA2A-201 | ADRA2A | P08913 | Alpha-2A adrenergic receptor | chr10 | GO:0006260 | Not Cancer Driver | No | 46 | 0.0989247311827957 | 162 | 9 | 0.0193548387096774 | 0 |
| ATR-201 | ATR | Q13535 | Serine/threonine-protein kinase ATR | chr3 | GO:0006260 | Census, Compendium | Yes | 261 | 0.098714069591528 | 107 | 11 | 0.0041603630862329 | 1 |
| BLM-201 | BLM | P54132 | RecQ-like DNA helicase BLM | chr15 | GO:0006260 | Census | Yes | 112 | 0.0790402258292166 | 671 | 53 | 0.0374029640084686 | 9 |
| CDK1-203 | CDK1 | P06493 | Cyclin-dependent kinase 1 | chr10 | GO:0006260 | Not Cancer Driver | No | 26 | 0.0875420875420875 | 1 | 0 | 0.0 | 0 |
| CDK2-201 | CDK2 | P24941 | Cyclin-dependent kinase 2 | chr12 | GO:0006260 | Not Cancer Driver | No | 17 | 0.0570469798657718 | 0 | 0 | 0.0 | 0 |
| CHAF1A-201 | CHAF1A | Q13111 | Chromatin assembly factor 1 subunit A | chr19 | GO:0006260 | Not Cancer Driver | No | 66 | 0.0690376569037656 | 768 | 48 | 0.0502092050209205 | 0 |
| CHAF1B-201 | CHAF1B | Q13112 | Chromatin assembly factor 1 subunit B | chr21 | GO:0006260 | Not Cancer Driver | No | 45 | 0.0805008944543828 | 189 | 23 | 0.0411449016100178 | 0 |
| CHEK1-204 | CHEK1 | O14757 | Serine/threonine-protein kinase Chk1 | chr11 | GO:0006260 | Not Cancer Driver | No | 42 | 0.088235294117647 | 86 | 13 | 0.0273109243697479 | 0 |
| CHTF18-201 | CHTF18 | Q8WVB6 | Chromosome transmission fidelity protein 18 homolog | chr16 | GO:0006260 | Not Cancer Driver | No | 72 | 0.0738461538461538 | 511 | 44 | 0.0451282051282051 | 0 |
| CHTF8-202 | CHTF8 | P0CG13 | Chromosome transmission fidelity protein 8 homolog | chr16 | GO:0006260 | Not Cancer Driver | No | 9 | 0.0743801652892562 | 7 | 0 | 0.0 | 0 |
| CINP-201 | CINP | Q9BW66 | Cyclin-dependent kinase 2-interacting protein | chr14 | GO:0006260 | Not Cancer Driver | No | 15 | 0.070754716981132 | 41 | 3 | 0.0141509433962264 | 0 |
| DBF4-201 | DBF4 | Q9UBU7 | Protein DBF4 homolog A | chr7 | GO:0006260 | Not Cancer Driver | No | 48 | 0.0712166172106825 | 334 | 18 | 0.0267062314540059 | 0 |
| DHX9-201 | DHX9 | Q08211 | ATP-dependent RNA helicase A | chr1 | GO:0006260 | Compendium | Yes | 125 | 0.0984251968503937 | 332 | 30 | 0.0236220472440944 | 0 |
| DNA2-201 | DNA2 | P51530 | DNA replication ATP-dependent helicase/nuclease DNA2 | chr10 | GO:0006260 | Not Cancer Driver | No | 72 | 0.0679245283018867 | 52 | 4 | 0.0037735849056603 | 3 |
| DNAJC2-203 | DNAJC2 | Q99543 | DnaJ homolog subfamily C member 2 | chr7 | GO:0006260 | Not Cancer Driver | No | 40 | 0.0644122383252818 | 426 | 30 | 0.0483091787439613 | 0 |
| DONSON-201 | DONSON | Q9NYP3 | Protein downstream neighbor of Son | chr21 | GO:0006260 | Not Cancer Driver | No | 30 | 0.0530035335689045 | 218 | 9 | 0.0159010600706713 | 6 |
| DSCC1-201 | DSCC1 | Q9BVC3 | Sister chromatid cohesion protein DCC1 | chr8 | GO:0006260 | Not Cancer Driver | No | 14 | 0.0356234096692111 | 41 | 2 | 0.005089058524173 | 0 |
| DTD1-201 | DTD1 | Q8TEA8 | D-aminoacyl-tRNA deacylase 1 | chr20 | GO:0006260 | Not Cancer Driver | No | 37 | 0.1770334928229665 | 93 | 22 | 0.1052631578947368 | 0 |
| DTL-201 | DTL | Q9NZJ0 | Denticleless protein homolog | chr1 | GO:0006260 | Not Cancer Driver | No | 53 | 0.0726027397260273 | 333 | 38 | 0.0520547945205479 | 0 |
| DUT-201 | DUT | P33316 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | chr15 | GO:0006260 | Not Cancer Driver | No | 12 | 0.0476190476190476 | 128 | 6 | 0.0238095238095238 | 1 |
| E4F1-201 | E4F1 | Q66K89 | Transcription factor E4F1 | chr16 | GO:0006260 | Not Cancer Driver | No | 61 | 0.0778061224489796 | 464 | 33 | 0.0420918367346938 | 0 |
| ENST00000635511 | PCLAF | Q15004 | PCNA-associated factor | chr15 | GO:0006260 | Not Cancer Driver | No | 0 | 0.0 | 0 | 0 | 0.0 | 0 |
| ENST00000649896 | POLA2 | Q14181 | DNA polymerase alpha subunit B | chr11 | GO:0006260 | Not Cancer Driver | No | 45 | 0.0774526678141136 | 121 | 15 | 0.0258175559380378 | 0 |
| FAM111A-213 | FAM111A | Q96PZ2 | Serine protease FAM111A | chr11 | GO:0006260 | Not Cancer Driver | No | 53 | 0.0867430441898527 | 169 | 17 | 0.027823240589198 | 5 |
| FAM111B-201 | FAM111B | Q6SJ93 | Serine protease FAM111B | chr11 | GO:0006260 | Not Cancer Driver | No | 57 | 0.0776566757493188 | 190 | 11 | 0.0149863760217983 | 3 |
| FEN1-201 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0006260 | Census | Yes | 29 | 0.0763157894736842 | 111 | 13 | 0.0342105263157894 | 0 |
| GMNC-201 | GMNC | A6NCL1 | Geminin coiled-coil domain-containing protein 1 | chr3 | GO:0006260 | Not Cancer Driver | No | 9 | 0.0269461077844311 | 205 | 7 | 0.0209580838323353 | 0 |
| GRWD1-201 | GRWD1 | Q9BQ67 | Glutamate-rich WD repeat-containing protein 1 | chr19 | GO:0006260 | Not Cancer Driver | No | 32 | 0.0717488789237668 | 188 | 9 | 0.0201793721973094 | 0 |
| HELB-201 | HELB | Q8NG08 | DNA helicase B | chr12 | GO:0006260 | Not Cancer Driver | No | 96 | 0.0883164673413063 | 302 | 24 | 0.0220791168353265 | 0 |
| KAT7-201 | KAT7 | O95251 | Histone acetyltransferase KAT7 | chr17 | GO:0006260 | Census | Yes | 64 | 0.1047463175122749 | 327 | 27 | 0.044189852700491 | 0 |
| KIN-201 | KIN | O60870 | DNA/RNA-binding protein KIN17 | chr10 | GO:0006260 | Not Cancer Driver | No | 36 | 0.0916030534351145 | 137 | 10 | 0.0254452926208651 | 0 |
| MCM2-201 | MCM2 | P49736 | DNA replication licensing factor MCM2 | chr3 | GO:0006260 | Not Cancer Driver | No | 77 | 0.0851769911504424 | 277 | 33 | 0.036504424778761 | 1 |
| MCM4-222 | MCM4 | P33991 | DNA replication licensing factor MCM4 | chr8 | GO:0006260 | Not Cancer Driver | No | 93 | 0.1077636152954808 | 215 | 29 | 0.033603707995365 | 0 |
| MCM5-201 | MCM5 | P33992 | DNA replication licensing factor MCM5 | chr22 | GO:0006260 | Not Cancer Driver | No | 68 | 0.0926430517711171 | 110 | 15 | 0.0204359673024523 | 1 |
| MCM6-201 | MCM6 | Q14566 | DNA replication licensing factor MCM6 | chr2 | GO:0006260 | Not Cancer Driver | No | 78 | 0.0950060901339829 | 122 | 11 | 0.0133982947624847 | 0 |
| MCM7-201 | MCM7 | P33993 | DNA replication licensing factor MCM7 | chr7 | GO:0006260 | Not Cancer Driver | No | 75 | 0.1043115438108484 | 128 | 16 | 0.0222531293463143 | 0 |
| MCM8-205 | MCM8 | Q9UJA3 | DNA helicase MCM8 | chr20 | GO:0006260 | Not Cancer Driver | No | 61 | 0.0726190476190476 | 188 | 11 | 0.013095238095238 | 1 |
| MCM9-209 | MCM9 | Q9NXL9 | DNA helicase MCM9 | chr6 | GO:0006260 | Not Cancer Driver | No | 39 | 0.0341207349081364 | 525 | 8 | 0.0069991251093613 | 0 |
| NAP1L1-226 | NAP1L1 | P55209 | Nucleosome assembly protein 1-like 1 | chr12 | GO:0006260 | Not Cancer Driver | No | 31 | 0.0792838874680307 | 207 | 18 | 0.0460358056265984 | 0 |
| NASP-201 | NASP | P49321 | Nuclear autoantigenic sperm protein | chr1 | GO:0006260 | Not Cancer Driver | No | 61 | 0.0774111675126903 | 618 | 53 | 0.0672588832487309 | 0 |
| NFIA-207 | NFIA | Q12857 | Nuclear factor 1 A-type | chr1 | GO:0006260 | Not Cancer Driver | No | 54 | 0.106090373280943 | 347 | 43 | 0.0844793713163064 | 0 |
| NFIB-205 | NFIB | O00712 | Nuclear factor 1 B-type | chr9 | GO:0006260 | Census | Yes | 48 | 0.1142857142857142 | 254 | 26 | 0.0619047619047619 | 3 |
| NFIC-203 | NFIC | P08651 | Nuclear factor 1 C-type | chr19 | GO:0006260 | Not Cancer Driver | No | 48 | 0.0944881889763779 | 329 | 30 | 0.0590551181102362 | 0 |
| NFIX-214 | NFIX | Q14938 | Nuclear factor 1 X-type | chr19 | GO:0006260 | Not Cancer Driver | No | 45 | 0.0896414342629482 | 305 | 26 | 0.0517928286852589 | 6 |
| NT5M-201 | NT5M | Q9NPB1 | 5'(3')-deoxyribonucleotidase, mitochondrial | chr17 | GO:0006260 | Not Cancer Driver | No | 14 | 0.0614035087719298 | 0 | 0 | 0.0 | 0 |
| ORC3-202 | ORC3 | Q9UBD5 | Origin recognition complex subunit 3 | chr6 | GO:0006260 | Not Cancer Driver | No | 45 | 0.0632911392405063 | 64 | 4 | 0.0056258790436005 | 0 |
| ORC5-201 | ORC5 | O43913 | Origin recognition complex subunit 5 | chr7 | GO:0006260 | Not Cancer Driver | No | 27 | 0.0620689655172413 | 16 | 2 | 0.0045977011494252 | 0 |
| PCLAF-201 | PCLAF | Q15004 | PCNA-associated factor | chr15 | GO:0006260 | Not Cancer Driver | No | 15 | 0.1351351351351351 | 112 | 16 | 0.1441441441441441 | 0 |
| PIF1-205 | PIF1 | Q9H611 | ATP-dependent DNA helicase PIF1 | chr15 | GO:0006260 | Not Cancer Driver | No | 44 | 0.0686427457098284 | 210 | 9 | 0.0140405616224648 | 0 |
| POLA1-201 | POLA1 | P09884 | DNA polymerase alpha catalytic subunit | chrX | GO:0006260 | Not Cancer Driver | No | 113 | 0.0772913816689466 | 347 | 30 | 0.0205198358413132 | 3 |
| POLA2-201 | POLA2 | Q14181 | DNA polymerase alpha subunit B | chr11 | GO:0006260 | Not Cancer Driver | No | 49 | 0.0819397993311036 | 102 | 15 | 0.0250836120401337 | 0 |
| POLD1-201 | POLD1 | P28340 | DNA polymerase delta catalytic subunit | chr19 | GO:0006260 | Census, Compendium | Yes | 118 | 0.1065943992773261 | 210 | 17 | 0.015356820234869 | 2 |
| POLD2-218 | POLD2 | P49005 | DNA polymerase delta subunit 2 | chr7 | GO:0006260 | Not Cancer Driver | No | 38 | 0.0810234541577825 | 65 | 3 | 0.0063965884861407 | 0 |
| POLE-201 | POLE | Q07864 | DNA polymerase epsilon catalytic subunit A | chr12 | GO:0006260 | Census, Compendium | Yes | 234 | 0.1023622047244094 | 240 | 31 | 0.0135608048993875 | 3 |
| POLE2-201 | POLE2 | P56282 | DNA polymerase epsilon subunit 2 | chr14 | GO:0006260 | Not Cancer Driver | No | 37 | 0.0702087286527514 | 32 | 1 | 0.0018975332068311 | 0 |
| POLE3-202 | POLE3 | Q9NRF9 | DNA polymerase epsilon subunit 3 | chr9 | GO:0006260 | Not Cancer Driver | No | 5 | 0.0340136054421768 | 117 | 5 | 0.0340136054421768 | 0 |
| POLH-202 | POLH | Q9Y253 | DNA polymerase eta | chr6 | GO:0006260 | Not Cancer Driver | No | 49 | 0.0687237026647966 | 291 | 15 | 0.0210378681626928 | 10 |
| POLI-208 | POLI | Q9UNA4 | DNA polymerase iota | chr18 | GO:0006260 | Not Cancer Driver | No | 50 | 0.0675675675675675 | 302 | 20 | 0.027027027027027 | 0 |
| POLK-201 | POLK | Q9UBT6 | DNA polymerase kappa | chr5 | GO:0006260 | Not Cancer Driver | No | 66 | 0.0758620689655172 | 294 | 25 | 0.028735632183908 | 0 |
| POLL-203 | POLL | Q9UGP5 | DNA polymerase lambda | chr10 | GO:0006260 | Not Cancer Driver | No | 57 | 0.0991304347826086 | 215 | 13 | 0.0226086956521739 | 0 |
| PTMS-201 | PTMS | P20962 | Parathymosin | chr12 | GO:0006260 | Not Cancer Driver | No | 4 | 0.0392156862745098 | 102 | 4 | 0.0392156862745098 | 0 |
| RBBP4-202 | RBBP4 | Q09028 | Histone-binding protein RBBP4 | chr1 | GO:0006260 | Not Cancer Driver | No | 40 | 0.0941176470588235 | 169 | 19 | 0.0447058823529411 | 0 |
| RBBP6-201 | RBBP6 | Q7Z6E9 | E3 ubiquitin-protein ligase RBBP6 | chr16 | GO:0006260 | Not Cancer Driver | No | 87 | 0.0485491071428571 | 1627 | 85 | 0.0474330357142857 | 0 |
| RBBP7-203 | RBBP7 | Q16576 | Histone-binding protein RBBP7 | chrX | GO:0006260 | Not Cancer Driver | No | 42 | 0.0988235294117647 | 138 | 8 | 0.0188235294117647 | 0 |
| RBMS1-201 | RBMS1 | P29558 | RNA-binding motif, single-stranded-interacting protein 1 | chr2 | GO:0006260 | Not Cancer Driver | No | 38 | 0.0935960591133004 | 244 | 27 | 0.0665024630541872 | 0 |
| RECQL4-209 | RECQL4 | O94761 | ATP-dependent DNA helicase Q4 | chr8 | GO:0006260 | Census, Compendium | Yes | 105 | 0.0869205298013245 | 612 | 54 | 0.0447019867549668 | 1 |
| RECQL5-201 | RECQL5 | O94762 | ATP-dependent DNA helicase Q5 | chr17 | GO:0006260 | Not Cancer Driver | No | 101 | 0.1019172552976791 | 499 | 57 | 0.0575176589303733 | 0 |
| REPIN1-203 | REPIN1 | Q9BWE0 | Replication initiator 1 | chr7 | GO:0006260 | Not Cancer Driver | No | 50 | 0.0881834215167548 | 261 | 20 | 0.0352733686067019 | 0 |
| REV1-201 | REV1 | Q9UBZ9 | DNA repair protein REV1 | chr2 | GO:0006260 | Not Cancer Driver | No | 91 | 0.0727418065547561 | 663 | 51 | 0.0407673860911271 | 0 |
| RFC3-201 | RFC3 | P40938 | Replication factor C subunit 3 | chr13 | GO:0006260 | Not Cancer Driver | No | 22 | 0.0617977528089887 | 13 | 1 | 0.0028089887640449 | 0 |
| RFC5-204 | RFC5 | P40937 | Replication factor C subunit 5 | chr12 | GO:0006260 | Not Cancer Driver | No | 26 | 0.0764705882352941 | 20 | 2 | 0.0058823529411764 | 0 |
| RMI1-202 | RMI1 | Q9H9A7 | RecQ-mediated genome instability protein 1 | chr9 | GO:0006260 | Not Cancer Driver | No | 38 | 0.0608 | 243 | 16 | 0.0256 | 0 |
| RMI2-201 | RMI2 | Q96E14 | RecQ-mediated genome instability protein 2 | chr16 | GO:0006260 | Census | Yes | 6 | 0.0408163265306122 | 88 | 3 | 0.0204081632653061 | 0 |
| RNASEH2A-201 | RNASEH2A | O75792 | Ribonuclease H2 subunit A | chr19 | GO:0006260 | Not Cancer Driver | No | 29 | 0.0969899665551839 | 31 | 1 | 0.0033444816053511 | 7 |
| RPA1-201 | RPA1 | P27694 | Replication protein A 70 kDa DNA-binding subunit | chr17 | GO:0006260 | Not Cancer Driver | No | 45 | 0.073051948051948 | 98 | 7 | 0.0113636363636363 | 1 |
| RPA2-203 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | GO:0006260 | Not Cancer Driver | No | 20 | 0.074074074074074 | 117 | 12 | 0.0444444444444444 | 0 |
| RPA3-201 | RPA3 | P35244 | Replication protein A 14 kDa subunit | chr7 | GO:0006260 | Not Cancer Driver | No | 10 | 0.0826446280991735 | 4 | 1 | 0.0082644628099173 | 0 |
| RPA4-201 | RPA4 | Q13156 | Replication protein A 30 kDa subunit | chrX | GO:0006260 | Not Cancer Driver | No | 56 | 0.21455938697318 | 59 | 10 | 0.0383141762452107 | 0 |
| SDE2-201 | SDE2 | Q6IQ49 | Splicing regulator SDE2 | chr1 | GO:0006260 | Not Cancer Driver | No | 40 | 0.0886917960088691 | 290 | 23 | 0.0509977827050997 | 0 |
| SET-204 | SET | Q01105 | Protein SET | chr9 | GO:0006260 | Census, Compendium | Yes | 19 | 0.0655172413793103 | 221 | 12 | 0.0413793103448275 | 2 |
| SIN3A-202 | SIN3A | Q96ST3 | Paired amphipathic helix protein Sin3a | chr15 | GO:0006260 | Compendium | Yes | 137 | 0.1076197957580518 | 617 | 60 | 0.0471327572663 | 0 |
| SLX4-201 | SLX4 | Q8IY92 | Structure-specific endonuclease subunit SLX4 | chr16 | GO:0006260 | Not Cancer Driver | No | 201 | 0.1095965103598691 | 1586 | 175 | 0.0954198473282442 | 0 |
| SSRP1-201 | SSRP1 | Q08945 | FACT complex subunit SSRP1 | chr11 | GO:0006260 | Not Cancer Driver | No | 66 | 0.0930888575458392 | 308 | 22 | 0.0310296191819464 | 0 |
| STRA8-201 | STRA8 | Q7Z7C7 | Stimulated by retinoic acid gene 8 protein homolog | chr7 | GO:0006260 | Not Cancer Driver | No | 27 | 0.0818181818181818 | 105 | 7 | 0.0212121212121212 | 0 |
| SUPT16H-201 | SUPT16H | Q9Y5B9 | FACT complex subunit SPT16 | chr14 | GO:0006260 | Not Cancer Driver | No | 109 | 0.1041069723018147 | 303 | 34 | 0.0324737344794651 | 0 |
| TBRG1-203 | TBRG1 | Q3YBR2 | Transforming growth factor beta regulator 1 | chr11 | GO:0006260 | Not Cancer Driver | No | 14 | 0.0340632603406326 | 175 | 3 | 0.0072992700729927 | 0 |
| TICRR-201 | TICRR | Q7Z2Z1 | Treslin | chr15 | GO:0006260 | Not Cancer Driver | No | 152 | 0.0795811518324607 | 1314 | 100 | 0.0523560209424083 | 0 |
| TOP1-201 | TOP1 | P11387 | DNA topoisomerase 1 | chr20 | GO:0006260 | Census, Compendium | Yes | 50 | 0.065359477124183 | 391 | 19 | 0.0248366013071895 | 0 |
| TOP1MT-201 | TOP1MT | Q969P6 | DNA topoisomerase I, mitochondrial | chr8 | GO:0006260 | Not Cancer Driver | No | 77 | 0.1281198003327787 | 171 | 25 | 0.0415973377703826 | 0 |
| TREX1-205 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:0006260 | Not Cancer Driver | No | 24 | 0.0764331210191082 | 98 | 7 | 0.0222929936305732 | 17 |
| UPF1-207 | UPF1 | Q92900 | Regulator of nonsense transcripts 1 | chr19 | GO:0006260 | Not Cancer Driver | No | 114 | 0.1009743135518157 | 330 | 33 | 0.0292294065544729 | 0 |
| WRN-201 | WRN | Q14191 | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | chr8 | GO:0006260 | Census, Compendium | Yes | 133 | 0.092877094972067 | 374 | 29 | 0.0202513966480446 | 2 |
| ZPR1-201 | ZPR1 | O75312 | Zinc finger protein ZPR1 | chr11 | GO:0006260 | Not Cancer Driver | No | 22 | 0.0479302832244008 | 291 | 16 | 0.0348583877995642 | 0 |