Total number of protein in "GO:0006302" GO term: 76
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABRAXAS1-201 | ABRAXAS1 | Q6UWZ7 | BRCA1-A complex subunit Abraxas 1 | chr4 | GO:0006302 | Not Cancer Driver | No | 18 | 0.0440097799511002 | 113 | 9 | 0.0220048899755501 | 1 |
| ACTR5-201 | ACTR5 | Q9H9F9 | Actin-related protein 5 | chr20 | GO:0006302 | Not Cancer Driver | No | 42 | 0.0691927512355848 | 163 | 12 | 0.0197693574958813 | 0 |
| ACTR8-201 | ACTR8 | Q9H981 | Actin-related protein 8 | chr3 | GO:0006302 | Not Cancer Driver | No | 48 | 0.0769230769230769 | 240 | 18 | 0.0288461538461538 | 0 |
| APLF-201 | APLF | Q8IW19 | Aprataxin and PNK-like factor | chr2 | GO:0006302 | Not Cancer Driver | No | 43 | 0.0841487279843444 | 411 | 37 | 0.0724070450097847 | 0 |
| ATM-229 | ATM | Q13315 | Serine-protein kinase ATM | chr11 | GO:0006302 | Census, Compendium | Yes | 358 | 0.1171465968586387 | 226 | 29 | 0.0094895287958115 | 41 |
| ATR-201 | ATR | Q13535 | Serine/threonine-protein kinase ATR | chr3 | GO:0006302 | Census, Compendium | Yes | 261 | 0.098714069591528 | 107 | 11 | 0.0041603630862329 | 1 |
| BABAM1-208 | BABAM1 | Q9NWV8 | BRISC and BRCA1-A complex member 1 | chr19 | GO:0006302 | Not Cancer Driver | No | 20 | 0.060790273556231 | 113 | 6 | 0.0182370820668693 | 0 |
| BABAM2-204 | BABAM2 | Q9NXR7 | BRISC and BRCA1-A complex member 2 | chr2 | GO:0006302 | Not Cancer Driver | No | 35 | 0.0913838120104438 | 0 | 0 | 0.0 | 0 |
| BRCA1-203 | BRCA1 | P38398 | Breast cancer type 1 susceptibility protein | chr17 | GO:0006302 | Census, Compendium | Yes | 167 | 0.0896403650026838 | 1466 | 127 | 0.0681696188942565 | 34 |
| BRCA2-201 | BRCA2 | P51587 | Breast cancer type 2 susceptibility protein | chr13 | GO:0006302 | Census, Compendium | Yes | 310 | 0.0906963136337039 | 1545 | 152 | 0.0444704505558806 | 46 |
| BRCC3-204 | BRCC3 | P46736 | Lys-63-specific deubiquitinase BRCC36 | chrX | GO:0006302 | Not Cancer Driver | No | 22 | 0.0696202531645569 | 74 | 4 | 0.0126582278481012 | 0 |
| BRIP1-201 | BRIP1 | Q9BX63 | Fanconi anemia group J protein | chr17 | GO:0006302 | Census | Yes | 118 | 0.0944755804643715 | 399 | 41 | 0.032826261008807 | 6 |
| CDCA5-201 | CDCA5 | Q96FF9 | Sororin | chr11 | GO:0006302 | Not Cancer Driver | No | 24 | 0.0952380952380952 | 211 | 20 | 0.0793650793650793 | 0 |
| CHEK2-206 | CHEK2 | O96017 | Serine/threonine-protein kinase Chk2 | chr22 | GO:0006302 | Census, Compendium | Yes | 72 | 0.1325966850828729 | 157 | 19 | 0.0349907918968692 | 11 |
| CIB1-201 | CIB1 | Q99828 | Calcium and integrin-binding protein 1 | chr15 | GO:0006302 | Not Cancer Driver | No | 16 | 0.0837696335078534 | 6 | 1 | 0.0052356020942408 | 0 |
| CSNK2A1-201 | CSNK2A1 | P68400 | Casein kinase II subunit alpha | chr20 | GO:0006302 | Not Cancer Driver | No | 47 | 0.1202046035805626 | 75 | 6 | 0.0153452685421994 | 4 |
| CSNK2A2-201 | CSNK2A2 | P19784 | Casein kinase II subunit alpha' | chr16 | GO:0006302 | Not Cancer Driver | No | 25 | 0.0714285714285714 | 13 | 1 | 0.0028571428571428 | 0 |
| DDX1-201 | DDX1 | Q92499 | ATP-dependent RNA helicase DDX1 | chr2 | GO:0006302 | Not Cancer Driver | No | 59 | 0.0797297297297297 | 91 | 10 | 0.0135135135135135 | 0 |
| DTX3L-201 | DTX3L | Q8TDB6 | E3 ubiquitin-protein ligase DTX3L | chr3 | GO:0006302 | Not Cancer Driver | No | 60 | 0.081081081081081 | 260 | 19 | 0.0256756756756756 | 0 |
| EME1-201 | EME1 | Q96AY2 | Crossover junction endonuclease EME1 | chr17 | GO:0006302 | Not Cancer Driver | No | 34 | 0.0596491228070175 | 302 | 23 | 0.0403508771929824 | 0 |
| EME2-205 | EME2 | A4GXA9 | Probable crossover junction endonuclease EME2 | chr16 | GO:0006302 | Not Cancer Driver | No | 21 | 0.0554089709762532 | 127 | 5 | 0.0131926121372031 | 0 |
| ENST00000640655 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0006302 | Not Cancer Driver | No | 92 | 0.0758450123660346 | 721 | 45 | 0.0370981038746908 | 0 |
| ESCO2-201 | ESCO2 | Q56NI9 | N-acetyltransferase ESCO2 | chr8 | GO:0006302 | Not Cancer Driver | No | 42 | 0.0698835274542429 | 293 | 18 | 0.0299500831946755 | 1 |
| EXD2-214 | EXD2 | Q9NVH0 | Exonuclease 3'-5' domain-containing protein 2 | chr14 | GO:0006302 | Not Cancer Driver | No | 47 | 0.0756843800322061 | 178 | 12 | 0.0193236714975845 | 0 |
| EYA1-202 | EYA1 | Q99502 | Eyes absent homolog 1 | chr8 | GO:0006302 | Not Cancer Driver | No | 128 | 0.2162162162162162 | 342 | 75 | 0.1266891891891892 | 15 |
| EYA3-203 | EYA3 | Q99504 | Eyes absent homolog 3 | chr1 | GO:0006302 | Not Cancer Driver | No | 44 | 0.0767888307155322 | 310 | 30 | 0.0523560209424083 | 0 |
| FEN1-201 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0006302 | Census | Yes | 29 | 0.0763157894736842 | 111 | 13 | 0.0342105263157894 | 0 |
| GGN-201 | GGN | Q86UU5 | Gametogenetin | chr19 | GO:0006302 | Not Cancer Driver | No | 51 | 0.0782208588957055 | 624 | 51 | 0.0782208588957055 | 0 |
| H2AX-202 | H2AX | P16104 | Histone H2AX | chr11 | GO:0006302 | Not Cancer Driver | No | 19 | 0.1328671328671328 | 68 | 8 | 0.0559440559440559 | 0 |
| HPF1-201 | HPF1 | Q9NWY4 | Histone PARylation factor 1 | chr4 | GO:0006302 | Not Cancer Driver | No | 19 | 0.0549132947976878 | 23 | 0 | 0.0 | 0 |
| INO80-209 | INO80 | Q9ULG1 | Chromatin-remodeling ATPase INO80 | chr15 | GO:0006302 | Compendium | Yes | 137 | 0.0880462724935732 | 682 | 67 | 0.0430591259640102 | 0 |
| KAT5-203 | KAT5 | Q92993 | Histone acetyltransferase KAT5 | chr11 | GO:0006302 | Not Cancer Driver | No | 45 | 0.087719298245614 | 174 | 16 | 0.0311890838206627 | 3 |
| LIG3-202 | LIG3 | P49916 | DNA ligase 3 | chr17 | GO:0006302 | Not Cancer Driver | No | 92 | 0.0911793855302279 | 281 | 26 | 0.0257680872150644 | 4 |
| LIG4-202 | LIG4 | P49917 | DNA ligase 4 | chr13 | GO:0006302 | Not Cancer Driver | No | 103 | 0.1130625686059275 | 63 | 10 | 0.0109769484083424 | 2 |
| MAD2L2-207 | MAD2L2 | Q9UI95 | Mitotic spindle assembly checkpoint protein MAD2B | chr1 | GO:0006302 | Not Cancer Driver | No | 16 | 0.0758293838862559 | 0 | 0 | 0.0 | 1 |
| MARF1-201 | MARF1 | Q9Y4F3 | Meiosis regulator and mRNA stability factor 1 | chr16 | GO:0006302 | Not Cancer Driver | No | 125 | 0.0717566016073478 | 525 | 43 | 0.0246842709529276 | 0 |
| MEIOC-201 | MEIOC | A2RUB1 | Meiosis-specific coiled-coil domain-containing protein MEIOC | chr17 | GO:0006302 | Not Cancer Driver | No | 58 | 0.0609243697478991 | 531 | 32 | 0.0336134453781512 | 0 |
| MPND-201 | MPND | Q8N594 | MPN domain-containing protein | chr19 | GO:0006302 | Not Cancer Driver | No | 34 | 0.0721868365180467 | 165 | 8 | 0.0169851380042462 | 0 |
| MRE11-201 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0006302 | Not Cancer Driver | No | 61 | 0.0861581920903954 | 292 | 28 | 0.03954802259887 | 1 |
| MSH2-201 | MSH2 | P43246 | DNA mismatch repair protein Msh2 | chr2 | GO:0006302 | Census | Yes | 55 | 0.0588865096359743 | 37 | 1 | 0.0010706638115631 | 63 |
| MTA1-201 | MTA1 | Q13330 | Metastasis-associated protein MTA1 | chr14 | GO:0006302 | Not Cancer Driver | No | 68 | 0.0951048951048951 | 328 | 33 | 0.0461538461538461 | 0 |
| MUS81-201 | MUS81 | Q96NY9 | Crossover junction endonuclease MUS81 | chr11 | GO:0006302 | Not Cancer Driver | No | 47 | 0.0852994555353902 | 235 | 25 | 0.0453720508166969 | 0 |
| NBN-201 | NBN | O60934 | Nibrin | chr8 | GO:0006302 | Census | Yes | 63 | 0.0835543766578249 | 420 | 45 | 0.059681697612732 | 1 |
| NSD2-218 | NSD2 | O96028 | Histone-lysine N-methyltransferase NSD2 | chr4 | GO:0006302 | Census, Compendium | Yes | 121 | 0.0886446886446886 | 553 | 42 | 0.0307692307692307 | 5 |
| PARP1-203 | PARP1 | P09874 | Poly [ADP-ribose] polymerase 1 | chr1 | GO:0006302 | Not Cancer Driver | No | 88 | 0.0867850098619329 | 322 | 28 | 0.0276134122287968 | 0 |
| PARP2-201 | PARP2 | Q9UGN5 | Poly [ADP-ribose] polymerase 2 | chr14 | GO:0006302 | Not Cancer Driver | No | 44 | 0.0754716981132075 | 172 | 16 | 0.0274442538593482 | 0 |
| PARP3-201 | PARP3 | Q9Y6F1 | Protein mono-ADP-ribosyltransferase PARP3 | chr3 | GO:0006302 | Not Cancer Driver | No | 48 | 0.0900562851782364 | 272 | 27 | 0.0506566604127579 | 0 |
| PARP9-201 | PARP9 | Q8IXQ6 | Protein mono-ADP-ribosyltransferase PARP9 | chr3 | GO:0006302 | Not Cancer Driver | No | 85 | 0.0995316159250585 | 45 | 3 | 0.0035128805620608 | 0 |
| PIAS4-201 | PIAS4 | Q8N2W9 | E3 SUMO-protein ligase PIAS4 | chr19 | GO:0006302 | Not Cancer Driver | No | 40 | 0.0784313725490196 | 143 | 18 | 0.0352941176470588 | 0 |
| PLK1-201 | PLK1 | P53350 | Serine/threonine-protein kinase PLK1 | chr16 | GO:0006302 | Not Cancer Driver | No | 68 | 0.1127694859038142 | 120 | 14 | 0.0232172470978441 | 0 |
| POLN-210 | POLN | Q7Z5Q5 | DNA polymerase nu | chr4 | GO:0006302 | Not Cancer Driver | No | 87 | 0.0966666666666666 | 247 | 17 | 0.0188888888888888 | 0 |
| POLQ-201 | POLQ | O75417 | DNA polymerase theta | chr3 | GO:0006302 | Census, Compendium | Yes | 274 | 0.1057915057915057 | 956 | 94 | 0.0362934362934362 | 0 |
| PPP5C-201 | PPP5C | P53041 | Serine/threonine-protein phosphatase 5 | chr19 | GO:0006302 | Not Cancer Driver | No | 58 | 0.1162324649298597 | 73 | 10 | 0.0200400801603206 | 0 |
| PRKDC-201 | PRKDC | P78527 | DNA-dependent protein kinase catalytic subunit | chr8 | GO:0006302 | Not Cancer Driver | No | 385 | 0.0932655038759689 | 421 | 43 | 0.0104166666666666 | 2 |
| RAD21-201 | RAD21 | O60216 | Double-strand-break repair protein rad21 homolog | chr8 | GO:0006302 | Census, Compendium | Yes | 84 | 0.1331220285261489 | 421 | 56 | 0.0887480190174326 | 3 |
| RAD50-201 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0006302 | Not Cancer Driver | No | 106 | 0.0807926829268292 | 730 | 50 | 0.0381097560975609 | 0 |
| RAD52-202 | RAD52 | P43351 | DNA repair protein RAD52 homolog | chr12 | GO:0006302 | Not Cancer Driver | No | 30 | 0.0717703349282296 | 252 | 24 | 0.0574162679425837 | 0 |
| REC8-209 | REC8 | O95072 | Meiotic recombination protein REC8 homolog | chr14 | GO:0006302 | Not Cancer Driver | No | 45 | 0.0822669104204753 | 245 | 18 | 0.0329067641681901 | 0 |
| RNF168-201 | RNF168 | Q8IYW5 | E3 ubiquitin-protein ligase RNF168 | chr3 | GO:0006302 | Not Cancer Driver | No | 66 | 0.1155866900175131 | 473 | 56 | 0.0980735551663747 | 0 |
| RNF169-201 | RNF169 | Q8NCN4 | E3 ubiquitin-protein ligase RNF169 | chr11 | GO:0006302 | Not Cancer Driver | No | 41 | 0.057909604519774 | 638 | 40 | 0.0564971751412429 | 0 |
| RNF8-202 | RNF8 | O76064 | E3 ubiquitin-protein ligase RNF8 | chr6 | GO:0006302 | Not Cancer Driver | No | 31 | 0.0639175257731958 | 226 | 14 | 0.0288659793814433 | 0 |
| SETX-201 | SETX | Q7Z333 | Probable helicase senataxin | chr9 | GO:0006302 | Not Cancer Driver | No | 213 | 0.0795666791184161 | 1248 | 89 | 0.0332461710870377 | 19 |
| SIRT6-202 | SIRT6 | Q8N6T7 | NAD-dependent protein deacylase sirtuin-6 | chr19 | GO:0006302 | Not Cancer Driver | No | 24 | 0.0676056338028169 | 165 | 6 | 0.0169014084507042 | 0 |
| SMCHD1-201 | SMCHD1 | A6NHR9 | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 | chr18 | GO:0006302 | Not Cancer Driver | No | 166 | 0.0827930174563591 | 345 | 34 | 0.0169576059850374 | 42 |
| TDP1-201 | TDP1 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | chr14 | GO:0006302 | Not Cancer Driver | No | 64 | 0.1052631578947368 | 179 | 20 | 0.0328947368421052 | 1 |
| TDP2-202 | TDP2 | O95551 | Tyrosyl-DNA phosphodiesterase 2 | chr6 | GO:0006302 | Not Cancer Driver | No | 38 | 0.1049723756906077 | 80 | 4 | 0.011049723756906 | 0 |
| TENT4A-201 | TENT4A | Q5XG87 | Terminal nucleotidyltransferase 4A | chr5 | GO:0006302 | Not Cancer Driver | No | 78 | 0.0984848484848484 | 461 | 37 | 0.0467171717171717 | 0 |
| TNKS1BP1-201 | TNKS1BP1 | Q9C0C2 | 182 kDa tankyrase-1-binding protein | chr11 | GO:0006302 | Not Cancer Driver | No | 167 | 0.0965876229034123 | 1726 | 166 | 0.0960092539039907 | 0 |
| TP53-201 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0006302 | Census, Compendium | Yes | 2742 | 6.977099236641221 | 282 | 1364 | 3.470737913486005 | 60 |
| TRIP13-201 | TRIP13 | Q15645 | Pachytene checkpoint protein 2 homolog | chr5 | GO:0006302 | Not Cancer Driver | No | 49 | 0.1134259259259259 | 30 | 5 | 0.011574074074074 | 1 |
| UIMC1-212 | UIMC1 | Q96RL1 | BRCA1-A complex subunit RAP80 | chr5 | GO:0006302 | Not Cancer Driver | No | 38 | 0.0528511821974965 | 610 | 31 | 0.043115438108484 | 0 |
| VCP-201 | VCP | P55072 | Transitional endoplasmic reticulum ATPase | chr9 | GO:0006302 | Not Cancer Driver | No | 74 | 0.0918114143920595 | 186 | 14 | 0.0173697270471464 | 12 |
| WRN-201 | WRN | Q14191 | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | chr8 | GO:0006302 | Census, Compendium | Yes | 133 | 0.092877094972067 | 374 | 29 | 0.0202513966480446 | 2 |
| XRCC4-205 | XRCC4 | Q13426 | DNA repair protein XRCC4 | chr5 | GO:0006302 | Not Cancer Driver | No | 33 | 0.0982142857142857 | 173 | 23 | 0.0684523809523809 | 3 |
| XRCC5-201 | XRCC5 | P13010 | X-ray repair cross-complementing protein 5 | chr2 | GO:0006302 | Not Cancer Driver | No | 53 | 0.0724043715846994 | 119 | 6 | 0.0081967213114754 | 0 |
| ZGRF1-208 | ZGRF1 | Q86YA3 | Protein ZGRF1 | chr4 | GO:0006302 | Not Cancer Driver | No | 147 | 0.0698669201520912 | 883 | 68 | 0.0323193916349809 | 0 |