Total number of protein in "GO:0043491" GO term: 81
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKT1-218 | AKT1 | P31749 | RAC-alpha serine/threonine-protein kinase | chr14 | GO:0043491 | Census, Compendium | Yes | 99 | 0.20625 | 158 | 19 | 0.0395833333333333 | 4 |
| ATG14-201 | ATG14 | Q6ZNE5 | Beclin 1-associated autophagy-related key regulator | chr14 | GO:0043491 | Not Cancer Driver | No | 43 | 0.0873983739837398 | 209 | 23 | 0.0467479674796747 | 0 |
| AXL-201 | AXL | P30530 | Tyrosine-protein kinase receptor UFO | chr19 | GO:0043491 | Not Cancer Driver | No | 131 | 0.1465324384787472 | 342 | 51 | 0.0570469798657718 | 0 |
| BANK1-201 | BANK1 | Q8NDB2 | B-cell scaffold protein with ankyrin repeats | chr4 | GO:0043491 | Not Cancer Driver | No | 109 | 0.1388535031847133 | 395 | 58 | 0.0738853503184713 | 0 |
| BTBD10-201 | BTBD10 | Q9BSF8 | BTB/POZ domain-containing protein 10 | chr11 | GO:0043491 | Not Cancer Driver | No | 46 | 0.0968421052631579 | 250 | 23 | 0.0484210526315789 | 0 |
| BTN2A2-202 | BTN2A2 | Q8WVV5 | Butyrophilin subfamily 2 member A2 | chr6 | GO:0043491 | Not Cancer Driver | No | 58 | 0.1108986615678776 | 24 | 2 | 0.0038240917782026 | 0 |
| C1QBP-201 | C1QBP | Q07021 | Complement component 1 Q subcomponent-binding protein, mitochondrial | chr17 | GO:0043491 | Not Cancer Driver | No | 14 | 0.0496453900709219 | 103 | 5 | 0.0177304964539007 | 2 |
| C1QTNF12-201 | C1QTNF12 | Q5T7M4 | Adipolin | chr1 | GO:0043491 | Not Cancer Driver | No | 11 | 0.0364238410596026 | 105 | 4 | 0.0132450331125827 | 0 |
| CD160-202 | CD160 | O95971 | CD160 antigen | chr1 | GO:0043491 | Not Cancer Driver | No | 16 | 0.0883977900552486 | 2 | 0 | 0.0 | 0 |
| CD28-201 | CD28 | P10747 | T-cell-specific surface glycoprotein CD28 | chr2 | GO:0043491 | Census | Yes | 26 | 0.1181818181818181 | 18 | 6 | 0.0272727272727272 | 0 |
| CD2AP-201 | CD2AP | Q9Y5K6 | CD2-associated protein | chr6 | GO:0043491 | Not Cancer Driver | No | 51 | 0.0798122065727699 | 458 | 38 | 0.0594679186228482 | 0 |
| CD40-202 | CD40 | P25942 | Tumor necrosis factor receptor superfamily member 5 | chr20 | GO:0043491 | Not Cancer Driver | No | 32 | 0.1155234657039711 | 57 | 6 | 0.0216606498194945 | 2 |
| COL6A1-201 | COL6A1 | P12109 | Collagen alpha-1(VI) chain | chr21 | GO:0043491 | Not Cancer Driver | No | 68 | 0.0661478599221789 | 436 | 23 | 0.0223735408560311 | 12 |
| COL6A2-201 | COL6A2 | P12110 | Collagen alpha-2(VI) chain | chr21 | GO:0043491 | Not Cancer Driver | No | 176 | 0.1727183513248282 | 465 | 77 | 0.0755642787046123 | 10 |
| COL6A3-201 | COL6A3 | P12111 | Collagen alpha-3(VI) chain | chr2 | GO:0043491 | Not Cancer Driver | No | 379 | 0.1192949323260938 | 697 | 48 | 0.0151085930122757 | 14 |
| DLG1-269 | DLG1 | Q12959 | Disks large homolog 1 | chr3 | GO:0043491 | Not Cancer Driver | No | 89 | 0.0984513274336283 | 460 | 48 | 0.0530973451327433 | 0 |
| DRD2-202 | DRD2 | P14416 | D(2) dopamine receptor | chr11 | GO:0043491 | Not Cancer Driver | No | 91 | 0.2054176072234763 | 124 | 31 | 0.0699774266365688 | 0 |
| EDN1-201 | EDN1 | P05305 | Endothelin-1 | chr6 | GO:0043491 | Not Cancer Driver | No | 27 | 0.1273584905660377 | 98 | 16 | 0.0754716981132075 | 3 |
| ENST00000593731 | PIK3R2 | O00459 | Phosphatidylinositol 3-kinase regulatory subunit beta | chr19 | GO:0043491 | Not Cancer Driver | No | 83 | 0.114010989010989 | 418 | 40 | 0.0549450549450549 | 3 |
| EPHA2-201 | EPHA2 | P29317 | Ephrin type-A receptor 2 | chr1 | GO:0043491 | Compendium | Yes | 147 | 0.1506147540983606 | 188 | 33 | 0.033811475409836 | 3 |
| ERBB2-201 | ERBB2 | P04626 | Receptor tyrosine-protein kinase erbB-2 | chr17 | GO:0043491 | Census, Compendium | Yes | 249 | 0.198406374501992 | 315 | 32 | 0.0254980079681274 | 1 |
| ERBB3-201 | ERBB3 | P21860 | Receptor tyrosine-protein kinase erbB-3 | chr12 | GO:0043491 | Census, Compendium | Yes | 265 | 0.1974664679582712 | 398 | 59 | 0.0439642324888226 | 3 |
| ERRFI1-201 | ERRFI1 | Q9UJM3 | ERBB receptor feedback inhibitor 1 | chr1 | GO:0043491 | Not Cancer Driver | No | 36 | 0.0779220779220779 | 299 | 23 | 0.0497835497835497 | 0 |
| FCGR3A-205 | FCGR3A | P08637 | Low affinity immunoglobulin gamma Fc region receptor III-A | chr1 | GO:0043491 | Not Cancer Driver | No | 45 | 0.1771653543307086 | 0 | 0 | 0.0 | 1 |
| FGF2-201 | FGF2 | P09038 | Fibroblast growth factor 2 | chr4 | GO:0043491 | Not Cancer Driver | No | 17 | 0.0590277777777777 | 183 | 5 | 0.0173611111111111 | 0 |
| FKRP-201 | FKRP | Q9H9S5 | Ribitol 5-phosphate transferase FKRP | chr19 | GO:0043491 | Not Cancer Driver | No | 30 | 0.0606060606060606 | 22 | 2 | 0.004040404040404 | 32 |
| FLCN-201 | FLCN | Q8NFG4 | Folliculin | chr17 | GO:0043491 | Census, Compendium | Yes | 49 | 0.0846286701208981 | 159 | 20 | 0.0345423143350604 | 6 |
| GAB2-202 | GAB2 | Q9UQC2 | GRB2-associated-binding protein 2 | chr11 | GO:0043491 | Not Cancer Driver | No | 63 | 0.0931952662721893 | 540 | 53 | 0.0784023668639053 | 0 |
| GAS6-201 | GAS6 | Q14393 | Growth arrest-specific protein 6 | chr13 | GO:0043491 | Not Cancer Driver | No | 60 | 0.0884955752212389 | 43 | 3 | 0.0044247787610619 | 0 |
| GATA3-201 | GATA3 | P23771 | Trans-acting T-cell-specific transcription factor GATA-3 | chr10 | GO:0043491 | Census, Compendium | Yes | 99 | 0.2234762979683973 | 368 | 79 | 0.1783295711060948 | 2 |
| HTR2A-201 | HTR2A | P28223 | 5-hydroxytryptamine receptor 2A | chr13 | GO:0043491 | Not Cancer Driver | No | 75 | 0.1592356687898089 | 45 | 6 | 0.0127388535031847 | 0 |
| HTR2B-201 | HTR2B | P41595 | 5-hydroxytryptamine receptor 2B | chr2 | GO:0043491 | Not Cancer Driver | No | 25 | 0.0519750519750519 | 23 | 0 | 0.0 | 0 |
| IGF1R-217 | IGF1R | P08069 | Insulin-like growth factor 1 receptor | chr15 | GO:0043491 | Not Cancer Driver | No | 143 | 0.1046086320409656 | 265 | 30 | 0.021945866861741 | 6 |
| ILK-201 | ILK | Q13418 | Integrin-linked protein kinase | chr11 | GO:0043491 | Not Cancer Driver | No | 30 | 0.0663716814159292 | 72 | 7 | 0.0154867256637168 | 0 |
| INPP5F-221 | INPP5F | Q9Y2H2 | Phosphatidylinositide phosphatase SAC2 | chr10 | GO:0043491 | Not Cancer Driver | No | 94 | 0.0830388692579505 | 396 | 27 | 0.023851590106007 | 0 |
| IRS1-201 | IRS1 | P35568 | Insulin receptor substrate 1 | chr2 | GO:0043491 | Not Cancer Driver | No | 118 | 0.0950080515297906 | 1075 | 104 | 0.0837359098228663 | 2 |
| KBTBD2-201 | KBTBD2 | Q8IY47 | Kelch repeat and BTB domain-containing protein 2 | chr7 | GO:0043491 | Not Cancer Driver | No | 43 | 0.0690208667736757 | 25 | 2 | 0.0032102728731942 | 0 |
| LOX-201 | LOX | P28300 | Protein-lysine 6-oxidase | chr5 | GO:0043491 | Compendium | Yes | 31 | 0.0743405275779376 | 172 | 8 | 0.0191846522781774 | 4 |
| LRP2-205 | LRP2 | P98164 | Low-density lipoprotein receptor-related protein 2 | chr2 | GO:0043491 | Not Cancer Driver | No | 740 | 0.158968850698174 | 209 | 26 | 0.0055853920515574 | 1 |
| MERTK-201 | MERTK | Q12866 | Tyrosine-protein kinase Mer | chr2 | GO:0043491 | Not Cancer Driver | No | 134 | 0.1341341341341341 | 161 | 25 | 0.025025025025025 | 3 |
| MKRN2-201 | MKRN2 | Q9H000 | E3 ubiquitin-protein ligase makorin-2 | chr3 | GO:0043491 | Not Cancer Driver | No | 30 | 0.0721153846153846 | 145 | 7 | 0.016826923076923 | 0 |
| MTM1-203 | MTM1 | Q13496 | Myotubularin | chrX | GO:0043491 | Not Cancer Driver | No | 84 | 0.1393034825870646 | 79 | 8 | 0.0132669983416252 | 49 |
| NDP-202 | NDP | Q00604 | Norrin | chrX | GO:0043491 | Not Cancer Driver | No | 11 | 0.0827067669172932 | 0 | 0 | 0.0 | 45 |
| NF1-202 | NF1 | P21359 | Neurofibromin | chr17 | GO:0043491 | Census, Compendium | Yes | 285 | 0.1003874603733709 | 406 | 36 | 0.0126805213103205 | 75 |
| NKX3-1-201 | NKX3-1 | Q99801 | Homeobox protein Nkx-3.1 | chr8 | GO:0043491 | Not Cancer Driver | No | 26 | 0.1111111111111111 | 175 | 12 | 0.0512820512820512 | 0 |
| NYAP1-201 | NYAP1 | Q6ZVC0 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 | chr7 | GO:0043491 | Not Cancer Driver | No | 102 | 0.1212841854934601 | 792 | 101 | 0.1200951248513674 | 0 |
| NYAP2-202 | NYAP2 | Q9P242 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | chr2 | GO:0043491 | Not Cancer Driver | No | 187 | 0.2863705972434915 | 618 | 178 | 0.2725880551301684 | 0 |
| PAX2-205 | PAX2 | Q02962 | Paired box protein Pax-2 | chr10 | GO:0043491 | Not Cancer Driver | No | 49 | 0.1175059952038369 | 294 | 39 | 0.0935251798561151 | 22 |
| PEAR1-201 | PEAR1 | Q5VY43 | Platelet endothelial aggregation receptor 1 | chr1 | GO:0043491 | Not Cancer Driver | No | 115 | 0.1108968177434908 | 237 | 36 | 0.034715525554484 | 0 |
| PIK3CA-201 | PIK3CA | P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | chr3 | GO:0043491 | Census, Compendium | Yes | 1425 | 1.3342696629213484 | 38 | 9 | 0.0084269662921348 | 44 |
| PIK3CB-214 | PIK3CB | P42338 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | chr3 | GO:0043491 | Census, Compendium | Yes | 112 | 0.1046728971962616 | 42 | 3 | 0.002803738317757 | 0 |
| PIK3CD-202 | PIK3CD | O00329 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | chr1 | GO:0043491 | Not Cancer Driver | No | 116 | 0.1111111111111111 | 61 | 8 | 0.0076628352490421 | 1 |
| PIK3CG-205 | PIK3CG | P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | chr7 | GO:0043491 | Not Cancer Driver | No | 230 | 0.2087114337568058 | 122 | 28 | 0.0254083484573502 | 3 |
| PIK3R1-211 | PIK3R1 | P27986 | Phosphatidylinositol 3-kinase regulatory subunit alpha | chr5 | GO:0043491 | Census, Compendium | Yes | 122 | 0.1685082872928177 | 271 | 50 | 0.0690607734806629 | 2 |
| PIK3R2-201 | PIK3R2 | O00459 | Phosphatidylinositol 3-kinase regulatory subunit beta | chr19 | GO:0043491 | Not Cancer Driver | No | 83 | 0.114010989010989 | 418 | 40 | 0.0549450549450549 | 3 |
| PIK3R3-201 | PIK3R3 | Q92569 | Phosphatidylinositol 3-kinase regulatory subunit gamma | chr1 | GO:0043491 | Not Cancer Driver | No | 42 | 0.0911062906724512 | 149 | 17 | 0.0368763557483731 | 0 |
| PIK3R4-201 | PIK3R4 | Q99570 | Phosphoinositide 3-kinase regulatory subunit 4 | chr3 | GO:0043491 | Not Cancer Driver | No | 133 | 0.0979381443298969 | 315 | 32 | 0.0235640648011782 | 0 |
| PIK3R5-202 | PIK3R5 | Q8WYR1 | Phosphoinositide 3-kinase regulatory subunit 5 | chr17 | GO:0043491 | Not Cancer Driver | No | 107 | 0.1215909090909091 | 317 | 45 | 0.0511363636363636 | 1 |
| PLEKHA1-203 | PLEKHA1 | Q9HB21 | Pleckstrin homology domain-containing family A member 1 | chr10 | GO:0043491 | Not Cancer Driver | No | 48 | 0.1188118811881188 | 192 | 28 | 0.0693069306930693 | 0 |
| PLK3-201 | PLK3 | Q9H4B4 | Serine/threonine-protein kinase PLK3 | chr1 | GO:0043491 | Not Cancer Driver | No | 55 | 0.0851393188854489 | 203 | 11 | 0.0170278637770897 | 0 |
| PPARD-203 | PPARD | Q03181 | Peroxisome proliferator-activated receptor delta | chr6 | GO:0043491 | Not Cancer Driver | No | 51 | 0.1156462585034013 | 70 | 5 | 0.0113378684807256 | 0 |
| PREX2-201 | PREX2 | Q70Z35 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein | chr8 | GO:0043491 | Census, Compendium | Yes | 404 | 0.2515566625155666 | 235 | 56 | 0.0348692403486924 | 0 |
| PRR5-202 | PRR5 | P85299 | Proline-rich protein 5 | chr22 | GO:0043491 | Not Cancer Driver | No | 41 | 0.1056701030927835 | 177 | 18 | 0.0463917525773195 | 0 |
| PRR5L-216 | PRR5L | Q6MZQ0 | Proline-rich protein 5-like | chr11 | GO:0043491 | Not Cancer Driver | No | 45 | 0.1222826086956521 | 108 | 11 | 0.029891304347826 | 0 |
| PTEN-201 | PTEN | P60484 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | chr10 | GO:0043491 | Census, Compendium | Yes | 425 | 1.054590570719603 | 76 | 5 | 0.0124069478908188 | 37 |
| RPS6KB1-201 | RPS6KB1 | P23443 | Ribosomal protein S6 kinase beta-1 | chr17 | GO:0043491 | Not Cancer Driver | No | 36 | 0.0685714285714285 | 226 | 22 | 0.0419047619047619 | 0 |
| RPS6KB2-201 | RPS6KB2 | Q9UBS0 | Ribosomal protein S6 kinase beta-2 | chr11 | GO:0043491 | Not Cancer Driver | No | 34 | 0.0705394190871369 | 195 | 8 | 0.0165975103734439 | 0 |
| SERPINA12-203 | SERPINA12 | Q8IW75 | Serpin A12 | chr14 | GO:0043491 | Not Cancer Driver | No | 61 | 0.1473429951690821 | 22 | 3 | 0.0072463768115942 | 0 |
| SESN2-201 | SESN2 | P58004 | Sestrin-2 | chr1 | GO:0043491 | Not Cancer Driver | No | 54 | 0.1125 | 147 | 20 | 0.0416666666666666 | 0 |
| SETX-201 | SETX | Q7Z333 | Probable helicase senataxin | chr9 | GO:0043491 | Not Cancer Driver | No | 213 | 0.0795666791184161 | 1248 | 89 | 0.0332461710870377 | 19 |
| SMPD3-201 | SMPD3 | Q9NY59 | Sphingomyelin phosphodiesterase 3 | chr16 | GO:0043491 | Not Cancer Driver | No | 73 | 0.1114503816793893 | 224 | 26 | 0.0396946564885496 | 0 |
| SOX9-201 | SOX9 | P48436 | Transcription factor SOX-9 | chr17 | GO:0043491 | Compendium | Yes | 69 | 0.1355599214145383 | 497 | 66 | 0.1296660117878192 | 13 |
| STAT3-201 | STAT3 | P40763 | Signal transducer and activator of transcription 3 | chr17 | GO:0043491 | Census, Compendium | Yes | 93 | 0.1207792207792207 | 152 | 16 | 0.0207792207792207 | 15 |
| STK3-201 | STK3 | Q13188 | Serine/threonine-protein kinase 3 | chr8 | GO:0043491 | Not Cancer Driver | No | 48 | 0.0977596741344195 | 241 | 22 | 0.0448065173116089 | 0 |
| THEM4-201 | THEM4 | Q5T1C6 | Acyl-coenzyme A thioesterase THEM4 | chr1 | GO:0043491 | Not Cancer Driver | No | 12 | 0.05 | 14 | 0 | 0.0 | 0 |
| TMEM100-201 | TMEM100 | Q9NV29 | Transmembrane protein 100 | chr17 | GO:0043491 | Not Cancer Driver | No | 22 | 0.1641791044776119 | 0 | 0 | 0.0 | 0 |
| TNF-208 | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0043491 | Not Cancer Driver | No | 22 | 0.0944206008583691 | 45 | 2 | 0.0085836909871244 | 0 |
| TNFSF11-202 | TNFSF11 | O14788 | Tumor necrosis factor ligand superfamily member 11 | chr13 | GO:0043491 | Not Cancer Driver | No | 32 | 0.1009463722397476 | 57 | 0 | 0.0 | 1 |
| TSC2-201 | TSC2 | P49815 | Tuberin | chr16 | GO:0043491 | Census, Compendium | Yes | 156 | 0.0863309352517985 | 568 | 40 | 0.0221361372440509 | 49 |
| TYRO3-201 | TYRO3 | Q06418 | Tyrosine-protein kinase receptor TYRO3 | chr15 | GO:0043491 | Not Cancer Driver | No | 86 | 0.096629213483146 | 197 | 18 | 0.0202247191011235 | 0 |
| ZFP36L1-202 | ZFP36L1 | Q07352 | mRNA decay activator protein ZFP36L1 | chr14 | GO:0043491 | Compendium | Yes | 50 | 0.1479289940828402 | 212 | 26 | 0.0769230769230769 | 0 |