Total number of protein in "GO:0043525" GO term: 61
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABL1-201 | ABL1 | P00519 | Tyrosine-protein kinase ABL1 | chr9 | GO:0043525 | Census, Compendium | Yes | 106 | 0.0938053097345132 | 609 | 53 | 0.0469026548672566 | 2 |
| AIFM1-201 | AIFM1 | O95831 | Apoptosis-inducing factor 1, mitochondrial | chrX | GO:0043525 | Not Cancer Driver | No | 61 | 0.099510603588907 | 166 | 20 | 0.032626427406199 | 10 |
| ASCL1-201 | ASCL1 | P50553 | Achaete-scute homolog 1 | chr12 | GO:0043525 | Not Cancer Driver | No | 26 | 0.1101694915254237 | 183 | 18 | 0.0762711864406779 | 0 |
| ATF4-206 | ATF4 | P18848 | Cyclic AMP-dependent transcription factor ATF-4 | chr22 | GO:0043525 | Not Cancer Driver | No | 46 | 0.131054131054131 | 261 | 33 | 0.094017094017094 | 0 |
| ATM-229 | ATM | Q13315 | Serine-protein kinase ATM | chr11 | GO:0043525 | Census, Compendium | Yes | 358 | 0.1171465968586387 | 226 | 29 | 0.0094895287958115 | 41 |
| BACE1-201 | BACE1 | P56817 | Beta-secretase 1 | chr11 | GO:0043525 | Not Cancer Driver | No | 34 | 0.0678642714570858 | 53 | 2 | 0.0039920159680638 | 0 |
| BAX-202 | BAX | Q07812 | Apoptosis regulator BAX | chr19 | GO:0043525 | Census | Yes | 24 | 0.125 | 39 | 2 | 0.0104166666666666 | 0 |
| BCL2L11-204 | BCL2L11 | O43521 | Bcl-2-like protein 11 | chr2 | GO:0043525 | Not Cancer Driver | No | 37 | 0.1868686868686868 | 131 | 16 | 0.0808080808080808 | 0 |
| CASP10-201 | CASP10 | Q92851 | Caspase-10 | chr2 | GO:0043525 | Not Cancer Driver | No | 37 | 0.0710172744721689 | 126 | 9 | 0.0172744721689059 | 3 |
| CASP14-201 | CASP14 | P31944 | Caspase-14 | chr19 | GO:0043525 | Not Cancer Driver | No | 42 | 0.1735537190082644 | 84 | 10 | 0.0413223140495867 | 0 |
| CASP2-201 | CASP2 | P42575 | Caspase-2 | chr7 | GO:0043525 | Not Cancer Driver | No | 49 | 0.1084070796460177 | 42 | 11 | 0.0243362831858407 | 0 |
| CASP3-201 | CASP3 | P42574 | Caspase-3 | chr4 | GO:0043525 | Census | Yes | 19 | 0.0685920577617328 | 64 | 1 | 0.003610108303249 | 0 |
| CASP4-203 | CASP4 | P49662 | Caspase-4 | chr11 | GO:0043525 | Not Cancer Driver | No | 41 | 0.1087533156498673 | 103 | 11 | 0.0291777188328912 | 0 |
| CASP5-201 | CASP5 | P51878 | Caspase-5 | chr11 | GO:0043525 | Not Cancer Driver | No | 76 | 0.1751152073732718 | 61 | 13 | 0.0299539170506912 | 0 |
| CASP6-201 | CASP6 | P55212 | Caspase-6 | chr4 | GO:0043525 | Not Cancer Driver | No | 19 | 0.0648464163822525 | 24 | 4 | 0.0136518771331058 | 0 |
| CASP7-203 | CASP7 | P55210 | Caspase-7 | chr10 | GO:0043525 | Not Cancer Driver | No | 28 | 0.0924092409240924 | 75 | 7 | 0.0231023102310231 | 0 |
| CASP8-218 | CASP8 | Q14790 | Caspase-8 | chr2 | GO:0043525 | Census, Compendium | Yes | 116 | 0.2421711899791231 | 106 | 11 | 0.022964509394572 | 1 |
| CASP9-201 | CASP9 | P55211 | Caspase-9 | chr1 | GO:0043525 | Census | Yes | 26 | 0.0625 | 71 | 7 | 0.016826923076923 | 0 |
| CCL3-204 | CCL3 | P10147 | C-C motif chemokine 3 | chr17 | GO:0043525 | Not Cancer Driver | No | 13 | 0.1413043478260869 | 0 | 0 | 0.0 | 0 |
| CDC34-201 | CDC34 | P49427 | Ubiquitin-conjugating enzyme E2 R1 | chr19 | GO:0043525 | Not Cancer Driver | No | 19 | 0.0805084745762711 | 96 | 7 | 0.0296610169491525 | 0 |
| CDC42-208 | CDC42 | P60953 | Cell division control protein 42 homolog | chr1 | GO:0043525 | Not Cancer Driver | No | 21 | 0.1099476439790576 | 23 | 1 | 0.0052356020942408 | 1 |
| CDK5-204 | CDK5 | Q00535 | Cyclin-dependent kinase 5 | chr7 | GO:0043525 | Not Cancer Driver | No | 38 | 0.1301369863013698 | 5 | 0 | 0.0 | 0 |
| CDK5R1-201 | CDK5R1 | Q15078 | Cyclin-dependent kinase 5 activator 1 | chr17 | GO:0043525 | Not Cancer Driver | No | 29 | 0.0944625407166123 | 103 | 10 | 0.0325732899022801 | 0 |
| CFLAR-201 | CFLAR | O15519 | CASP8 and FADD-like apoptosis regulator | chr2 | GO:0043525 | Not Cancer Driver | No | 31 | 0.0645833333333333 | 44 | 1 | 0.0020833333333333 | 0 |
| CTNNB1-201 | CTNNB1 | P35222 | Catenin beta-1 | chr3 | GO:0043525 | Census, Compendium | Yes | 363 | 0.4647887323943662 | 288 | 291 | 0.3725992317541613 | 11 |
| DDIT3-201 | DDIT3 | P35638 | DNA damage-inducible transcript 3 protein | chr12 | GO:0043525 | Census | Yes | 19 | 0.1124260355029585 | 161 | 17 | 0.1005917159763313 | 0 |
| ENST00000695856 | CDC42 | P60953 | Cell division control protein 42 homolog | chr1 | GO:0043525 | Not Cancer Driver | No | 21 | 0.1099476439790576 | 23 | 1 | 0.0052356020942408 | 1 |
| EPHA7-202 | EPHA7 | Q15375 | Ephrin type-A receptor 7 | chr6 | GO:0043525 | Census, Compendium | Yes | 226 | 0.2264529058116232 | 71 | 10 | 0.0100200400801603 | 0 |
| FASLG-202 | FASLG | P48023 | Tumor necrosis factor ligand superfamily member 6 | chr1 | GO:0043525 | Not Cancer Driver | No | 51 | 0.1814946619217081 | 94 | 15 | 0.0533807829181494 | 1 |
| FOXO3-202 | FOXO3 | O43524 | Forkhead box protein O3 | chr6 | GO:0043525 | Census, Compendium | Yes | 54 | 0.0802377414561664 | 597 | 50 | 0.0742942050520059 | 0 |
| GCH1-204 | GCH1 | P30793 | GTP cyclohydrolase 1 | chr14 | GO:0043525 | Not Cancer Driver | No | 14 | 0.056 | 102 | 3 | 0.012 | 35 |
| GRIK2-202 | GRIK2 | Q13002 | Glutamate receptor ionotropic, kainate 2 | chr6 | GO:0043525 | Not Cancer Driver | No | 226 | 0.2488986784140969 | 57 | 15 | 0.0165198237885462 | 3 |
| GRN-201 | GRN | P28799 | Progranulin | chr17 | GO:0043525 | Not Cancer Driver | No | 64 | 0.1079258010118043 | 29 | 4 | 0.0067453625632377 | 1 |
| GSK3A-201 | GSK3A | P49840 | Glycogen synthase kinase-3 alpha | chr19 | GO:0043525 | Not Cancer Driver | No | 33 | 0.0683229813664596 | 180 | 5 | 0.010351966873706 | 0 |
| GSK3B-201 | GSK3B | P49841 | Glycogen synthase kinase-3 beta | chr3 | GO:0043525 | Not Cancer Driver | No | 34 | 0.0809523809523809 | 148 | 6 | 0.0142857142857142 | 0 |
| HTR2A-201 | HTR2A | P28223 | 5-hydroxytryptamine receptor 2A | chr13 | GO:0043525 | Not Cancer Driver | No | 75 | 0.1592356687898089 | 45 | 6 | 0.0127388535031847 | 0 |
| ITGA1-201 | ITGA1 | P56199 | Integrin alpha-1 | chr5 | GO:0043525 | Not Cancer Driver | No | 106 | 0.0899067005937235 | 107 | 8 | 0.006785411365564 | 0 |
| MAP2K4-201 | MAP2K4 | P45985 | Dual specificity mitogen-activated protein kinase kinase 4 | chr17 | GO:0043525 | Census, Compendium | Yes | 72 | 0.1804511278195488 | 137 | 23 | 0.0576441102756892 | 0 |
| MAP3K11-201 | MAP3K11 | Q16584 | Mitogen-activated protein kinase kinase kinase 11 | chr11 | GO:0043525 | Not Cancer Driver | No | 84 | 0.0991735537190082 | 466 | 50 | 0.0590318772136954 | 0 |
| MYB-205 | MYB | P10242 | Transcriptional activator Myb | chr6 | GO:0043525 | Census | Yes | 69 | 0.1078125 | 528 | 57 | 0.0890625 | 0 |
| MYBL2-201 | MYBL2 | P10244 | Myb-related protein B | chr20 | GO:0043525 | Not Cancer Driver | No | 74 | 0.1057142857142857 | 511 | 53 | 0.0757142857142857 | 0 |
| NF1-202 | NF1 | P21359 | Neurofibromin | chr17 | GO:0043525 | Census, Compendium | Yes | 285 | 0.1003874603733709 | 406 | 36 | 0.0126805213103205 | 75 |
| NFATC4-201 | NFATC4 | Q14934 | Nuclear factor of activated T-cells, cytoplasmic 4 | chr14 | GO:0043525 | Not Cancer Driver | No | 122 | 0.1352549889135255 | 685 | 92 | 0.1019955654101995 | 0 |
| NQO1-201 | NQO1 | P15559 | NAD(P)H dehydrogenase [quinone] 1 | chr16 | GO:0043525 | Not Cancer Driver | No | 11 | 0.0401459854014598 | 10 | 0 | 0.0 | 0 |
| NR3C1-203 | NR3C1 | P04150 | Glucocorticoid receptor | chr5 | GO:0043525 | Not Cancer Driver | No | 55 | 0.0707850707850707 | 364 | 20 | 0.0257400257400257 | 11 |
| NUPR1-201 | NUPR1 | O60356 | Nuclear protein 1 | chr16 | GO:0043525 | Not Cancer Driver | No | 10 | 0.1219512195121951 | 82 | 10 | 0.1219512195121951 | 0 |
| PCSK9-201 | PCSK9 | Q8NBP7 | Proprotein convertase subtilisin/kexin type 9 | chr1 | GO:0043525 | Not Cancer Driver | No | 73 | 0.1054913294797687 | 150 | 20 | 0.0289017341040462 | 8 |
| PHB1-201 | PHB1 | P35232 | Prohibitin 1 | chr17 | GO:0043525 | Not Cancer Driver | No | 21 | 0.0772058823529411 | 4 | 1 | 0.0036764705882352 | 0 |
| PITX3-201 | PITX3 | O75364 | Pituitary homeobox 3 | chr10 | GO:0043525 | Not Cancer Driver | No | 21 | 0.0695364238410596 | 155 | 11 | 0.0364238410596026 | 1 |
| POU4F1-201 | POU4F1 | Q01851 | POU domain, class 4, transcription factor 1 | chr13 | GO:0043525 | Not Cancer Driver | No | 33 | 0.0787589498806682 | 274 | 20 | 0.0477326968973747 | 1 |
| PRNP-201 | PRNP | P04156 | Major prion protein | chr20 | GO:0043525 | Not Cancer Driver | No | 28 | 0.1106719367588932 | 117 | 8 | 0.0316205533596837 | 19 |
| RIPK1-201 | RIPK1 | Q13546 | Receptor-interacting serine/threonine-protein kinase 1 | chr6 | GO:0043525 | Compendium | Yes | 59 | 0.0879284649776453 | 277 | 28 | 0.0417287630402384 | 1 |
| SRPK2-201 | SRPK2 | P78362 | SRSF protein kinase 2 | chr7 | GO:0043525 | Not Cancer Driver | No | 57 | 0.0828488372093023 | 344 | 31 | 0.0450581395348837 | 0 |
| ST8SIA2-201 | ST8SIA2 | Q92186 | Alpha-2,8-sialyltransferase 8B | chr15 | GO:0043525 | Not Cancer Driver | No | 67 | 0.1786666666666666 | 39 | 9 | 0.024 | 0 |
| TFAP2A-203 | TFAP2A | P05549 | Transcription factor AP-2-alpha | chr6 | GO:0043525 | Not Cancer Driver | No | 54 | 0.123006833712984 | 277 | 32 | 0.0728929384965831 | 4 |
| TFAP2B-202 | TFAP2B | Q92481 | Transcription factor AP-2-beta | chr6 | GO:0043525 | Not Cancer Driver | No | 77 | 0.1673913043478261 | 306 | 55 | 0.1195652173913043 | 5 |
| TGFB2-202 | TGFB2 | P61812 | Transforming growth factor beta-2 proprotein | chr1 | GO:0043525 | Not Cancer Driver | No | 44 | 0.1062801932367149 | 47 | 5 | 0.0120772946859903 | 4 |
| TNF-208 | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0043525 | Not Cancer Driver | No | 22 | 0.0944206008583691 | 45 | 2 | 0.0085836909871244 | 0 |
| TP53-201 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0043525 | Census, Compendium | Yes | 2742 | 6.977099236641221 | 282 | 1364 | 3.470737913486005 | 60 |
| TRAF7-201 | TRAF7 | Q6Q0C0 | E3 ubiquitin-protein ligase TRAF7 | chr16 | GO:0043525 | Census | Yes | 65 | 0.0970149253731343 | 121 | 13 | 0.0194029850746268 | 4 |
| UBE2M-201 | UBE2M | P61081 | NEDD8-conjugating enzyme Ubc12 | chr19 | GO:0043525 | Not Cancer Driver | No | 25 | 0.1366120218579235 | 32 | 4 | 0.0218579234972677 | 0 |