Total number of protein in "GO:0050731" GO term: 86
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABL1-201 | ABL1 | P00519 | Tyrosine-protein kinase ABL1 | chr9 | GO:0050731 | Census, Compendium | Yes | 106 | 0.0938053097345132 | 609 | 53 | 0.0469026548672566 | 2 |
| ACVR1-207 | ACVR1 | Q04771 | Activin receptor type-1 | chr2 | GO:0050731 | Census, Compendium | Yes | 71 | 0.1394891944990176 | 21 | 8 | 0.0157170923379174 | 6 |
| ADIPOQ-201 | ADIPOQ | Q15848 | Adiponectin | chr3 | GO:0050731 | Not Cancer Driver | No | 32 | 0.1311475409836065 | 92 | 16 | 0.0655737704918032 | 1 |
| ADNP-205 | ADNP | Q9H2P0 | Activity-dependent neuroprotector homeobox protein | chr20 | GO:0050731 | Not Cancer Driver | No | 96 | 0.087114337568058 | 615 | 52 | 0.0471869328493647 | 0 |
| ANGPT1-202 | ANGPT1 | Q15389 | Angiopoietin-1 | chr8 | GO:0050731 | Not Cancer Driver | No | 100 | 0.2008032128514056 | 131 | 10 | 0.0200803212851405 | 1 |
| ANGPT4-201 | ANGPT4 | Q9Y264 | Angiopoietin-4 | chr20 | GO:0050731 | Not Cancer Driver | No | 87 | 0.172962226640159 | 152 | 31 | 0.0616302186878727 | 0 |
| AREG-201 | AREG | P15514 | Amphiregulin | chr4 | GO:0050731 | Not Cancer Driver | No | 33 | 0.1309523809523809 | 152 | 26 | 0.1031746031746031 | 0 |
| ARHGEF2-203 | ARHGEF2 | Q92974 | Rho guanine nucleotide exchange factor 2 | chr1 | GO:0050731 | Not Cancer Driver | No | 121 | 0.1227180527383367 | 450 | 64 | 0.0649087221095334 | 0 |
| BANK1-201 | BANK1 | Q8NDB2 | B-cell scaffold protein with ankyrin repeats | chr4 | GO:0050731 | Not Cancer Driver | No | 109 | 0.1388535031847133 | 395 | 58 | 0.0738853503184713 | 0 |
| BMP6-201 | BMP6 | P22004 | Bone morphogenetic protein 6 | chr6 | GO:0050731 | Not Cancer Driver | No | 79 | 0.1539961013645224 | 228 | 41 | 0.0799220272904483 | 6 |
| CD36-214 | CD36 | P16671 | Platelet glycoprotein 4 | chr7 | GO:0050731 | Not Cancer Driver | No | 48 | 0.1016949152542373 | 12 | 3 | 0.0063559322033898 | 3 |
| CD3E-201 | CD3E | P07766 | T-cell surface glycoprotein CD3 epsilon chain | chr11 | GO:0050731 | Not Cancer Driver | No | 16 | 0.0772946859903381 | 72 | 6 | 0.0289855072463768 | 0 |
| CD4-201 | CD4 | P01730 | T-cell surface glycoprotein CD4 | chr12 | GO:0050731 | Not Cancer Driver | No | 50 | 0.1091703056768559 | 56 | 7 | 0.0152838427947598 | 0 |
| CD44-208 | CD44 | P16070 | CD44 antigen | chr11 | GO:0050731 | Not Cancer Driver | No | 58 | 0.0781671159029649 | 547 | 50 | 0.0673854447439353 | 0 |
| CD74-201 | CD74 | P04233 | HLA class II histocompatibility antigen gamma chain | chr5 | GO:0050731 | Census | Yes | 24 | 0.081081081081081 | 186 | 15 | 0.0506756756756756 | 0 |
| CD80-201 | CD80 | P33681 | T-lymphocyte activation antigen CD80 | chr3 | GO:0050731 | Not Cancer Driver | No | 33 | 0.1145833333333333 | 27 | 1 | 0.0034722222222222 | 0 |
| CLEC6A-201 | CLEC6A | Q6EIG7 | C-type lectin domain family 6 member A | chr12 | GO:0050731 | Not Cancer Driver | No | 34 | 0.1626794258373205 | 7 | 0 | 0.0 | 0 |
| CSF3-201 | CSF3 | P09919 | Granulocyte colony-stimulating factor | chr17 | GO:0050731 | Not Cancer Driver | No | 16 | 0.0772946859903381 | 7 | 0 | 0.0 | 0 |
| CSPG4-201 | CSPG4 | Q6UVK1 | Chondroitin sulfate proteoglycan 4 | chr15 | GO:0050731 | Not Cancer Driver | No | 187 | 0.0805340223944875 | 840 | 64 | 0.0275624461670973 | 0 |
| DGKQ-201 | DGKQ | P52824 | Diacylglycerol kinase theta | chr4 | GO:0050731 | Not Cancer Driver | No | 53 | 0.0562632696390658 | 268 | 11 | 0.0116772823779193 | 0 |
| EFNA1-202 | EFNA1 | P20827 | Ephrin-A1 | chr1 | GO:0050731 | Not Cancer Driver | No | 21 | 0.1024390243902439 | 46 | 2 | 0.0097560975609756 | 0 |
| EFNA5-201 | EFNA5 | P52803 | Ephrin-A5 | chr5 | GO:0050731 | Not Cancer Driver | No | 24 | 0.1052631578947368 | 25 | 6 | 0.0263157894736842 | 0 |
| EGF-201 | EGF | P01133 | Pro-epidermal growth factor | chr4 | GO:0050731 | Not Cancer Driver | No | 149 | 0.1234465617232808 | 193 | 22 | 0.0182270091135045 | 1 |
| EHD4-201 | EHD4 | Q9H223 | EH domain-containing protein 4 | chr15 | GO:0050731 | Not Cancer Driver | No | 39 | 0.0720887245841035 | 98 | 7 | 0.0129390018484288 | 0 |
| ENPP2-201 | ENPP2 | Q13822 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | chr8 | GO:0050731 | Not Cancer Driver | No | 123 | 0.1425260718424102 | 82 | 12 | 0.0139049826187717 | 0 |
| ENST00000560629 | ITGB3 | P05106 | Integrin beta-3 | chr17 | GO:0050731 | Not Cancer Driver | No | 92 | 0.1168996188055908 | 68 | 6 | 0.0076238881829733 | 27 |
| FGF10-201 | FGF10 | O15520 | Fibroblast growth factor 10 | chr5 | GO:0050731 | Not Cancer Driver | No | 42 | 0.2019230769230769 | 34 | 8 | 0.0384615384615384 | 2 |
| FGF7-201 | FGF7 | P21781 | Fibroblast growth factor 7 | chr15 | GO:0050731 | Not Cancer Driver | No | 26 | 0.134020618556701 | 22 | 4 | 0.0206185567010309 | 0 |
| FGF8-202 | FGF8 | P55075 | Fibroblast growth factor 8 | chr10 | GO:0050731 | Not Cancer Driver | No | 27 | 0.1158798283261802 | 79 | 8 | 0.0343347639484978 | 6 |
| GATA1-202 | GATA1 | P15976 | Erythroid transcription factor | chrX | GO:0050731 | Census, Compendium | Yes | 57 | 0.1380145278450363 | 242 | 34 | 0.0823244552058111 | 5 |
| GFRA1-201 | GFRA1 | P56159 | GDNF family receptor alpha-1 | chr10 | GO:0050731 | Not Cancer Driver | No | 99 | 0.2129032258064516 | 43 | 9 | 0.0193548387096774 | 0 |
| GHR-201 | GHR | P10912 | Growth hormone receptor | chr5 | GO:0050731 | Not Cancer Driver | No | 139 | 0.2178683385579937 | 229 | 59 | 0.0924764890282131 | 19 |
| HAX1-201 | HAX1 | O00165 | HCLS1-associated protein X-1 | chr1 | GO:0050731 | Not Cancer Driver | No | 30 | 0.1075268817204301 | 219 | 23 | 0.082437275985663 | 2 |
| HBEGF-201 | HBEGF | Q99075 | Proheparin-binding EGF-like growth factor | chr5 | GO:0050731 | Not Cancer Driver | No | 11 | 0.0528846153846153 | 63 | 2 | 0.0096153846153846 | 0 |
| HCLS1-201 | HCLS1 | P14317 | Hematopoietic lineage cell-specific protein | chr3 | GO:0050731 | Not Cancer Driver | No | 81 | 0.1666666666666666 | 448 | 75 | 0.1543209876543209 | 0 |
| HGF-201 | HGF | P14210 | Hepatocyte growth factor | chr7 | GO:0050731 | Compendium | Yes | 196 | 0.2692307692307692 | 43 | 16 | 0.0219780219780219 | 0 |
| HTR2A-201 | HTR2A | P28223 | 5-hydroxytryptamine receptor 2A | chr13 | GO:0050731 | Not Cancer Driver | No | 75 | 0.1592356687898089 | 45 | 6 | 0.0127388535031847 | 0 |
| IGF1-201 | IGF1 | P05019 | Insulin-like growth factor I | chr12 | GO:0050731 | Not Cancer Driver | No | 30 | 0.1538461538461538 | 87 | 18 | 0.0923076923076923 | 0 |
| IL11-201 | IL11 | P20809 | Interleukin-11 | chr19 | GO:0050731 | Not Cancer Driver | No | 10 | 0.050251256281407 | 70 | 4 | 0.0201005025125628 | 0 |
| IL15-202 | IL15 | P40933 | Interleukin-15 | chr4 | GO:0050731 | Not Cancer Driver | No | 20 | 0.1234567901234567 | 6 | 1 | 0.0061728395061728 | 0 |
| IL3-201 | IL3 | P08700 | Interleukin-3 | chr5 | GO:0050731 | Not Cancer Driver | No | 17 | 0.1118421052631579 | 22 | 2 | 0.0131578947368421 | 0 |
| IL5-201 | IL5 | P05113 | Interleukin-5 | chr5 | GO:0050731 | Not Cancer Driver | No | 7 | 0.0522388059701492 | 0 | 0 | 0.0 | 0 |
| IL6-201 | IL6 | P05231 | Interleukin-6 | chr7 | GO:0050731 | Not Cancer Driver | No | 32 | 0.1509433962264151 | 58 | 6 | 0.0283018867924528 | 0 |
| IL6R-202 | IL6R | P08887 | Interleukin-6 receptor subunit alpha | chr1 | GO:0050731 | Not Cancer Driver | No | 43 | 0.0918803418803418 | 166 | 19 | 0.0405982905982906 | 1 |
| ITGA5-201 | ITGA5 | P08648 | Integrin alpha-5 | chr12 | GO:0050731 | Not Cancer Driver | No | 89 | 0.0848427073403241 | 202 | 21 | 0.0200190657769304 | 0 |
| ITGB3-201 | ITGB3 | P05106 | Integrin beta-3 | chr17 | GO:0050731 | Not Cancer Driver | No | 92 | 0.116751269035533 | 68 | 5 | 0.0063451776649746 | 28 |
| KITLG-205 | KITLG | P21583 | Kit ligand | chr12 | GO:0050731 | Not Cancer Driver | No | 38 | 0.1391941391941392 | 61 | 6 | 0.0219780219780219 | 1 |
| LACRT-201 | LACRT | Q9GZZ8 | Extracellular glycoprotein lacritin | chr12 | GO:0050731 | Not Cancer Driver | No | 27 | 0.1956521739130435 | 90 | 21 | 0.1521739130434782 | 0 |
| LIF-201 | LIF | P15018 | Leukemia inhibitory factor | chr22 | GO:0050731 | Not Cancer Driver | No | 18 | 0.0891089108910891 | 0 | 0 | 0.0 | 0 |
| LRP4-201 | LRP4 | O75096 | Low-density lipoprotein receptor-related protein 4 | chr11 | GO:0050731 | Not Cancer Driver | No | 192 | 0.1007874015748031 | 267 | 22 | 0.0115485564304461 | 11 |
| LRP8-201 | LRP8 | Q14114 | Low-density lipoprotein receptor-related protein 8 | chr1 | GO:0050731 | Not Cancer Driver | No | 70 | 0.0726895119418483 | 190 | 17 | 0.0176531671858774 | 0 |
| LRRK1-201 | LRRK1 | Q38SD2 | Leucine-rich repeat serine/threonine-protein kinase 1 | chr15 | GO:0050731 | Not Cancer Driver | No | 214 | 0.1062034739454094 | 262 | 32 | 0.0158808933002481 | 0 |
| MIF-201 | MIF | P14174 | Macrophage migration inhibitory factor | chr22 | GO:0050731 | Not Cancer Driver | No | 4 | 0.0347826086956521 | 0 | 0 | 0.0 | 0 |
| MLST8-232 | MLST8 | Q9BVC4 | Target of rapamycin complex subunit LST8 | chr16 | GO:0050731 | Not Cancer Driver | No | 24 | 0.0736196319018405 | 45 | 3 | 0.00920245398773 | 0 |
| MTOR-201 | MTOR | P42345 | Serine/threonine-protein kinase mTOR | chr1 | GO:0050731 | Census, Compendium | Yes | 298 | 0.1169085916045508 | 298 | 28 | 0.0109846998823067 | 15 |
| NOD2-201 | NOD2 | Q9HC29 | Nucleotide-binding oligomerization domain-containing protein 2 | chr16 | GO:0050731 | Not Cancer Driver | No | 130 | 0.125 | 41 | 3 | 0.0028846153846153 | 15 |
| NRP1-206 | NRP1 | O14786 | Neuropilin-1 | chr10 | GO:0050731 | Compendium | Yes | 112 | 0.1213434452871072 | 212 | 25 | 0.0270855904658721 | 0 |
| NTF3-201 | NTF3 | P20783 | Neurotrophin-3 | chr12 | GO:0050731 | Not Cancer Driver | No | 49 | 0.1906614785992217 | 102 | 23 | 0.0894941634241245 | 0 |
| OSM-201 | OSM | P13725 | Oncostatin-M | chr22 | GO:0050731 | Not Cancer Driver | No | 36 | 0.1428571428571428 | 114 | 20 | 0.0793650793650793 | 0 |
| PAK2-201 | PAK2 | Q13177 | Serine/threonine-protein kinase PAK 2 | chr3 | GO:0050731 | Compendium | Yes | 61 | 0.116412213740458 | 242 | 31 | 0.0591603053435114 | 1 |
| PDGFB-201 | PDGFB | P01127 | Platelet-derived growth factor subunit B | chr22 | GO:0050731 | Census | Yes | 30 | 0.1244813278008298 | 99 | 16 | 0.0663900414937759 | 2 |
| PECAM1-203 | PECAM1 | P16284 | Platelet endothelial cell adhesion molecule | chr17 | GO:0050731 | Not Cancer Driver | No | 0 | 0.0 | 153 | 0 | 0.0 | 0 |
| PLCG2-206 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0050731 | Not Cancer Driver | No | 183 | 0.1446640316205533 | 144 | 18 | 0.0142292490118577 | 1 |
| PLPP3-201 | PLPP3 | O14495 | Phospholipid phosphatase 3 | chr1 | GO:0050731 | Not Cancer Driver | No | 42 | 0.135048231511254 | 10 | 1 | 0.0032154340836012 | 0 |
| PRNP-201 | PRNP | P04156 | Major prion protein | chr20 | GO:0050731 | Not Cancer Driver | No | 28 | 0.1106719367588932 | 117 | 8 | 0.0316205533596837 | 19 |
| PTK2B-201 | PTK2B | Q14289 | Protein-tyrosine kinase 2-beta | chr8 | GO:0050731 | Not Cancer Driver | No | 117 | 0.1159563924677899 | 263 | 23 | 0.0227948463825569 | 0 |
| PTPN11-201 | PTPN11 | Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | chr12 | GO:0050731 | Census, Compendium | Yes | 92 | 0.1551433389544688 | 260 | 27 | 0.0455311973018549 | 44 |
| PTPRC-209 | PTPRC | P08575 | Receptor-type tyrosine-protein phosphatase C | chr1 | GO:0050731 | Census, Compendium | Yes | 257 | 0.1967840735068912 | 462 | 91 | 0.0696784073506891 | 0 |
| PTPRJ-201 | PTPRJ | Q12913 | Receptor-type tyrosine-protein phosphatase eta | chr11 | GO:0050731 | Not Cancer Driver | No | 130 | 0.0972326103216155 | 403 | 39 | 0.0291697830964846 | 0 |
| RELN-203 | RELN | P78509 | Reelin | chr7 | GO:0050731 | Not Cancer Driver | No | 626 | 0.1809248554913294 | 108 | 13 | 0.003757225433526 | 7 |
| RICTOR-202 | RICTOR | Q6R327 | Rapamycin-insensitive companion of mTOR | chr5 | GO:0050731 | Not Cancer Driver | No | 144 | 0.0843091334894613 | 365 | 34 | 0.0199063231850117 | 0 |
| RIPK2-201 | RIPK2 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | chr8 | GO:0050731 | Not Cancer Driver | No | 43 | 0.0796296296296296 | 143 | 14 | 0.0259259259259259 | 0 |
| SEMA4D-208 | SEMA4D | Q92854 | Semaphorin-4D | chr9 | GO:0050731 | Not Cancer Driver | No | 93 | 0.1078886310904872 | 132 | 14 | 0.0162412993039443 | 0 |
| SRC-204 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | chr20 | GO:0050731 | Census | Yes | 40 | 0.0746268656716417 | 130 | 10 | 0.0186567164179104 | 1 |
| SYK-204 | SYK | P43405 | Tyrosine-protein kinase SYK | chr9 | GO:0050731 | Census | Yes | 75 | 0.1181102362204724 | 131 | 20 | 0.0314960629921259 | 4 |
| TDGF1-201 | TDGF1 | P13385 | Teratocarcinoma-derived growth factor 1 | chr3 | GO:0050731 | Not Cancer Driver | No | 34 | 0.1808510638297872 | 25 | 2 | 0.0106382978723404 | 0 |
| TGFA-201 | TGFA | P01135 | Protransforming growth factor alpha | chr2 | GO:0050731 | Not Cancer Driver | No | 17 | 0.10625 | 0 | 0 | 0.0 | 0 |
| TGFB1-201 | TGFB1 | P01137 | Transforming growth factor beta-1 proprotein | chr19 | GO:0050731 | Not Cancer Driver | No | 30 | 0.0769230769230769 | 44 | 3 | 0.0076923076923076 | 8 |
| THBS4-201 | THBS4 | P35443 | Thrombospondin-4 | chr5 | GO:0050731 | Not Cancer Driver | No | 99 | 0.1030176899063475 | 282 | 33 | 0.0343392299687825 | 0 |
| TNFRSF14-201 | TNFRSF14 | Q92956 | Tumor necrosis factor receptor superfamily member 14 | chr1 | GO:0050731 | Census, Compendium | Yes | 26 | 0.0918727915194346 | 54 | 4 | 0.0141342756183745 | 0 |
| TNK2-201 | TNK2 | Q07912 | Activated CDC42 kinase 1 | chr3 | GO:0050731 | Not Cancer Driver | No | 103 | 0.0992292870905587 | 598 | 66 | 0.0635838150289017 | 0 |
| TP53-201 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0050731 | Census, Compendium | Yes | 2742 | 6.977099236641221 | 282 | 1364 | 3.470737913486005 | 60 |
| TREM2-202 | TREM2 | Q9NZC2 | Triggering receptor expressed on myeloid cells 2 | chr6 | GO:0050731 | Not Cancer Driver | No | 31 | 0.1347826086956521 | 27 | 2 | 0.008695652173913 | 1 |
| VEGFA-226 | VEGFA | P15692 | Vascular endothelial growth factor A, long form | chr6 | GO:0050731 | Not Cancer Driver | No | 24 | 0.060759493670886 | 215 | 9 | 0.0227848101265822 | 0 |
| VTN-201 | VTN | P04004 | Vitronectin | chr17 | GO:0050731 | Not Cancer Driver | No | 52 | 0.1087866108786611 | 168 | 20 | 0.0418410041841004 | 0 |
| YES1-201 | YES1 | P07947 | Tyrosine-protein kinase Yes | chr18 | GO:0050731 | Not Cancer Driver | No | 48 | 0.0883977900552486 | 63 | 9 | 0.0165745856353591 | 0 |