Total number of protein in "GO:0051091" GO term: 97
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABRA-201 | ABRA | Q8N0Z2 | Actin-binding Rho-activating protein | chr8 | GO:0051091 | Not Cancer Driver | No | 83 | 0.2178477690288714 | 285 | 69 | 0.1811023622047244 | 0 |
| AKT1-218 | AKT1 | P31749 | RAC-alpha serine/threonine-protein kinase | chr14 | GO:0051091 | Census, Compendium | Yes | 99 | 0.20625 | 158 | 19 | 0.0395833333333333 | 4 |
| ANXA3-201 | ANXA3 | P12429 | Annexin A3 | chr4 | GO:0051091 | Not Cancer Driver | No | 41 | 0.1269349845201238 | 22 | 3 | 0.0092879256965944 | 0 |
| APP-201 | APP | P05067 | Amyloid-beta precursor protein | chr21 | GO:0051091 | Not Cancer Driver | No | 94 | 0.122077922077922 | 419 | 52 | 0.0675324675324675 | 12 |
| ARHGEF5-201 | ARHGEF5 | Q12774 | Rho guanine nucleotide exchange factor 5 | chr7 | GO:0051091 | Not Cancer Driver | No | 122 | 0.0763932373199749 | 1141 | 89 | 0.0557294927989981 | 0 |
| ARID5B-201 | ARID5B | Q14865 | AT-rich interactive domain-containing protein 5B | chr10 | GO:0051091 | Not Cancer Driver | No | 133 | 0.1119528619528619 | 770 | 82 | 0.069023569023569 | 0 |
| ATF2-201 | ATF2 | P15336 | Cyclic AMP-dependent transcription factor ATF-2 | chr2 | GO:0051091 | Not Cancer Driver | No | 42 | 0.0831683168316831 | 451 | 36 | 0.0712871287128712 | 0 |
| BEX1-201 | BEX1 | Q9HBH7 | Protein BEX1 | chrX | GO:0051091 | Not Cancer Driver | No | 18 | 0.144 | 114 | 17 | 0.136 | 0 |
| BMP2-201 | BMP2 | P12643 | Bone morphogenetic protein 2 | chr20 | GO:0051091 | Not Cancer Driver | No | 54 | 0.1363636363636363 | 140 | 22 | 0.0555555555555555 | 0 |
| CEBPG-201 | CEBPG | P53567 | CCAAT/enhancer-binding protein gamma | chr19 | GO:0051091 | Not Cancer Driver | No | 10 | 0.0666666666666666 | 141 | 9 | 0.06 | 0 |
| CLEC7A-202 | CLEC7A | Q9BXN2 | C-type lectin domain family 7 member A | chr12 | GO:0051091 | Not Cancer Driver | No | 31 | 0.1255060728744939 | 46 | 1 | 0.0040485829959514 | 0 |
| COPS5-201 | COPS5 | Q92905 | COP9 signalosome complex subunit 5 | chr8 | GO:0051091 | Not Cancer Driver | No | 27 | 0.0808383233532934 | 32 | 4 | 0.0119760479041916 | 0 |
| DDIT3-201 | DDIT3 | P35638 | DNA damage-inducible transcript 3 protein | chr12 | GO:0051091 | Census | Yes | 19 | 0.1124260355029585 | 161 | 17 | 0.1005917159763313 | 0 |
| DDR2-201 | DDR2 | Q16832 | Discoidin domain-containing receptor 2 | chr1 | GO:0051091 | Census | Yes | 129 | 0.1508771929824561 | 120 | 25 | 0.0292397660818713 | 7 |
| DVL2-201 | DVL2 | O14641 | Segment polarity protein dishevelled homolog DVL-2 | chr17 | GO:0051091 | Not Cancer Driver | No | 72 | 0.0978260869565217 | 515 | 52 | 0.0706521739130434 | 0 |
| EDN1-201 | EDN1 | P05305 | Endothelin-1 | chr6 | GO:0051091 | Not Cancer Driver | No | 27 | 0.1273584905660377 | 98 | 16 | 0.0754716981132075 | 3 |
| ENST00000681750 | RIGI | O95786 | Antiviral innate immune response receptor RIG-I | chr9 | GO:0051091 | Not Cancer Driver | No | 68 | 0.0777142857142857 | 58 | 5 | 0.0057142857142857 | 2 |
| EP300-201 | EP300 | Q09472 | Histone acetyltransferase p300 | chr22 | GO:0051091 | Census, Compendium | Yes | 203 | 0.084092792046396 | 1792 | 84 | 0.0347970173985087 | 1 |
| ESR1-201 | ESR1 | P03372 | Estrogen receptor | chr6 | GO:0051091 | Census, Compendium | Yes | 92 | 0.1546218487394958 | 198 | 19 | 0.0319327731092436 | 2 |
| ESR2-202 | ESR2 | Q92731 | Estrogen receptor beta | chr14 | GO:0051091 | Not Cancer Driver | No | 69 | 0.130188679245283 | 92 | 10 | 0.0188679245283018 | 1 |
| FANK1-203 | FANK1 | Q8TC84 | Fibronectin type 3 and ankyrin repeat domains protein 1 | chr10 | GO:0051091 | Not Cancer Driver | No | 60 | 0.1739130434782608 | 64 | 13 | 0.0376811594202898 | 0 |
| FOXA1-201 | FOXA1 | P55317 | Hepatocyte nuclear factor 3-alpha | chr14 | GO:0051091 | Census, Compendium | Yes | 85 | 0.1800847457627118 | 295 | 44 | 0.0932203389830508 | 0 |
| FZD1-201 | FZD1 | Q9UP38 | Frizzled-1 | chr7 | GO:0051091 | Not Cancer Driver | No | 65 | 0.1004636785162287 | 133 | 2 | 0.0030911901081916 | 0 |
| FZD2-201 | FZD2 | Q14332 | Frizzled-2 | chr17 | GO:0051091 | Not Cancer Driver | No | 73 | 0.1292035398230088 | 47 | 6 | 0.0106194690265486 | 2 |
| FZD4-201 | FZD4 | Q9ULV1 | Frizzled-4 | chr11 | GO:0051091 | Not Cancer Driver | No | 40 | 0.074487895716946 | 33 | 5 | 0.0093109869646182 | 17 |
| HDAC4-201 | HDAC4 | P56524 | Histone deacetylase 4 | chr2 | GO:0051091 | Not Cancer Driver | No | 145 | 0.1337638376383763 | 751 | 95 | 0.0876383763837638 | 3 |
| HDAC5-213 | HDAC5 | Q9UQL6 | Histone deacetylase 5 | chr17 | GO:0051091 | Not Cancer Driver | No | 93 | 0.0828877005347593 | 720 | 61 | 0.0543672014260249 | 0 |
| HIPK2-202 | HIPK2 | Q9H2X6 | Homeodomain-interacting protein kinase 2 | chr7 | GO:0051091 | Not Cancer Driver | No | 124 | 0.1035058430717863 | 686 | 76 | 0.0634390651085141 | 0 |
| HSF1-204 | HSF1 | Q00613 | Heat shock factor protein 1 | chr8 | GO:0051091 | Not Cancer Driver | No | 49 | 0.0926275992438563 | 336 | 30 | 0.0567107750472589 | 0 |
| IKBKE-203 | IKBKE | Q14164 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | chr1 | GO:0051091 | Not Cancer Driver | No | 90 | 0.1256983240223463 | 76 | 10 | 0.0139664804469273 | 0 |
| IL10-202 | IL10 | P22301 | Interleukin-10 | chr1 | GO:0051091 | Not Cancer Driver | No | 17 | 0.095505617977528 | 23 | 1 | 0.0056179775280898 | 0 |
| IL1B-201 | IL1B | P01584 | Interleukin-1 beta | chr2 | GO:0051091 | Not Cancer Driver | No | 32 | 0.1189591078066914 | 16 | 2 | 0.0074349442379182 | 0 |
| IL6-201 | IL6 | P05231 | Interleukin-6 | chr7 | GO:0051091 | Not Cancer Driver | No | 32 | 0.1509433962264151 | 58 | 6 | 0.0283018867924528 | 0 |
| JMY-201 | JMY | Q8N9B5 | Junction-mediating and -regulatory protein | chr5 | GO:0051091 | Not Cancer Driver | No | 58 | 0.0587044534412955 | 576 | 37 | 0.0374493927125506 | 0 |
| JUP-203 | JUP | P14923 | Junction plakoglobin | chr17 | GO:0051091 | Not Cancer Driver | No | 81 | 0.1087248322147651 | 242 | 24 | 0.0322147651006711 | 0 |
| KIT-201 | KIT | P10721 | Mast/stem cell growth factor receptor Kit | chr4 | GO:0051091 | Census, Compendium | Yes | 186 | 0.1905737704918032 | 84 | 24 | 0.0245901639344262 | 15 |
| LRP6-201 | LRP6 | O75581 | Low-density lipoprotein receptor-related protein 6 | chr12 | GO:0051091 | Not Cancer Driver | No | 148 | 0.0917544947303161 | 255 | 27 | 0.0167389956602603 | 5 |
| MAVS-202 | MAVS | Q7Z434 | Mitochondrial antiviral-signaling protein | chr20 | GO:0051091 | Not Cancer Driver | No | 55 | 0.1018518518518518 | 415 | 44 | 0.0814814814814814 | 0 |
| MBTPS2-202 | MBTPS2 | O43462 | Membrane-bound transcription factor site-2 protease | chrX | GO:0051091 | Not Cancer Driver | No | 41 | 0.0789980732177264 | 16 | 3 | 0.0057803468208092 | 9 |
| MID2-201 | MID2 | Q9UJV3 | Probable E3 ubiquitin-protein ligase MID2 | chrX | GO:0051091 | Not Cancer Driver | No | 81 | 0.110204081632653 | 96 | 19 | 0.0258503401360544 | 1 |
| MYOCD-201 | MYOCD | Q8IZQ8 | Myocardin | chr17 | GO:0051091 | Not Cancer Driver | No | 228 | 0.2430703624733475 | 856 | 211 | 0.2249466950959488 | 0 |
| NEUROD1-201 | NEUROD1 | Q13562 | Neurogenic differentiation factor 1 | chr2 | GO:0051091 | Not Cancer Driver | No | 68 | 0.1910112359550561 | 203 | 42 | 0.1179775280898876 | 2 |
| NEUROD2-201 | NEUROD2 | Q15784 | Neurogenic differentiation factor 2 | chr17 | GO:0051091 | Not Cancer Driver | No | 20 | 0.0523560209424083 | 210 | 11 | 0.0287958115183246 | 2 |
| NEUROG1-201 | NEUROG1 | Q92886 | Neurogenin-1 | chr5 | GO:0051091 | Not Cancer Driver | No | 26 | 0.1097046413502109 | 179 | 17 | 0.0717299578059071 | 0 |
| NEUROG2-201 | NEUROG2 | Q9H2A3 | Neurogenin-2 | chr4 | GO:0051091 | Not Cancer Driver | No | 20 | 0.0735294117647058 | 211 | 18 | 0.0661764705882353 | 0 |
| NFAM1-201 | NFAM1 | Q8NET5 | NFAT activation molecule 1 | chr22 | GO:0051091 | Not Cancer Driver | No | 21 | 0.0777777777777777 | 120 | 14 | 0.0518518518518518 | 0 |
| NHLH2-201 | NHLH2 | Q02577 | Helix-loop-helix protein 2 | chr1 | GO:0051091 | Not Cancer Driver | No | 15 | 0.1111111111111111 | 83 | 7 | 0.0518518518518518 | 0 |
| NKX6-1-201 | NKX6-1 | P78426 | Homeobox protein Nkx-6.1 | chr4 | GO:0051091 | Not Cancer Driver | No | 20 | 0.0544959128065395 | 325 | 18 | 0.0490463215258855 | 0 |
| NODAL-201 | NODAL | Q96S42 | Nodal homolog | chr10 | GO:0051091 | Not Cancer Driver | No | 34 | 0.0979827089337175 | 34 | 9 | 0.0259365994236311 | 4 |
| PARK7-201 | PARK7 | Q99497 | Parkinson disease protein 7 | chr1 | GO:0051091 | Not Cancer Driver | No | 8 | 0.0423280423280423 | 30 | 0 | 0.0 | 6 |
| PHB2-203 | PHB2 | Q99623 | Prohibitin-2 | chr12 | GO:0051091 | Not Cancer Driver | No | 25 | 0.0836120401337792 | 26 | 4 | 0.0133779264214046 | 0 |
| PLCG2-206 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0051091 | Not Cancer Driver | No | 183 | 0.1446640316205533 | 144 | 18 | 0.0142292490118577 | 1 |
| PLPP3-201 | PLPP3 | O14495 | Phospholipid phosphatase 3 | chr1 | GO:0051091 | Not Cancer Driver | No | 42 | 0.135048231511254 | 10 | 1 | 0.0032154340836012 | 0 |
| PPARG-201 | PPARG | P37231 | Peroxisome proliferator-activated receptor gamma | chr3 | GO:0051091 | Census | Yes | 60 | 0.1188118811881188 | 44 | 3 | 0.0059405940594059 | 3 |
| PPARGC1A-201 | PPARGC1A | Q9UBK2 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | chr4 | GO:0051091 | Not Cancer Driver | No | 91 | 0.1140350877192982 | 613 | 85 | 0.106516290726817 | 0 |
| PPARGC1B-201 | PPARGC1B | Q86YN6 | Peroxisome proliferator-activated receptor gamma coactivator 1-beta | chr5 | GO:0051091 | Not Cancer Driver | No | 96 | 0.093841642228739 | 849 | 77 | 0.075268817204301 | 0 |
| PPRC1-201 | PPRC1 | Q5VV67 | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 | chr10 | GO:0051091 | Not Cancer Driver | No | 158 | 0.094951923076923 | 1474 | 134 | 0.0805288461538461 | 0 |
| PRKD2-201 | PRKD2 | Q9BZL6 | Serine/threonine-protein kinase D2 | chr19 | GO:0051091 | Compendium | Yes | 89 | 0.1013667425968109 | 247 | 26 | 0.0296127562642369 | 0 |
| PTEN-201 | PTEN | P60484 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | chr10 | GO:0051091 | Census, Compendium | Yes | 425 | 1.054590570719603 | 76 | 5 | 0.0124069478908188 | 37 |
| PYCARD-201 | PYCARD | Q9ULZ3 | Apoptosis-associated speck-like protein containing a CARD | chr16 | GO:0051091 | Not Cancer Driver | No | 12 | 0.0615384615384615 | 39 | 4 | 0.0205128205128205 | 0 |
| RGCC-201 | RGCC | Q9H4X1 | Regulator of cell cycle RGCC | chr13 | GO:0051091 | Not Cancer Driver | No | 4 | 0.0291970802919708 | 81 | 2 | 0.0145985401459854 | 0 |
| RIGI-202 | RIGI | O95786 | Antiviral innate immune response receptor RIG-I | chr9 | GO:0051091 | Not Cancer Driver | No | 78 | 0.0843243243243243 | 61 | 6 | 0.0064864864864864 | 2 |
| RNF220-203 | RNF220 | Q5VTB9 | E3 ubiquitin-protein ligase RNF220 | chr1 | GO:0051091 | Not Cancer Driver | No | 72 | 0.127208480565371 | 402 | 48 | 0.0848056537102473 | 2 |
| SMAD3-201 | SMAD3 | P84022 | Mothers against decapentaplegic homolog 3 | chr15 | GO:0051091 | Census, Compendium | Yes | 80 | 0.188235294117647 | 113 | 15 | 0.0352941176470588 | 5 |
| SMARCA4-201 | SMARCA4 | P51532 | Transcription activator BRG1 | chr19 | GO:0051091 | Census, Compendium | Yes | 300 | 0.1821493624772313 | 1078 | 163 | 0.0989678202792957 | 5 |
| SMARCB1-213 | SMARCB1 | Q12824 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | chr22 | GO:0051091 | Census, Compendium | Yes | 55 | 0.1428571428571428 | 141 | 26 | 0.0675324675324675 | 3 |
| SRF-201 | SRF | P11831 | Serum response factor | chr6 | GO:0051091 | Not Cancer Driver | No | 30 | 0.0590551181102362 | 443 | 29 | 0.0570866141732283 | 0 |
| STING1-201 | STING1 | Q86WV6 | Stimulator of interferon genes protein | chr5 | GO:0051091 | Not Cancer Driver | No | 39 | 0.1029023746701846 | 66 | 12 | 0.0316622691292876 | 4 |
| STK3-201 | STK3 | Q13188 | Serine/threonine-protein kinase 3 | chr8 | GO:0051091 | Not Cancer Driver | No | 48 | 0.0977596741344195 | 241 | 22 | 0.0448065173116089 | 0 |
| TCF3-201 | TCF3 | P15923 | Transcription factor E2-alpha | chr19 | GO:0051091 | Census | Yes | 40 | 0.0611620795107033 | 658 | 40 | 0.0611620795107033 | 0 |
| TFDP1-201 | TFDP1 | Q14186 | Transcription factor Dp-1 | chr13 | GO:0051091 | Not Cancer Driver | No | 61 | 0.148780487804878 | 246 | 36 | 0.0878048780487804 | 0 |
| TNF-208 | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0051091 | Not Cancer Driver | No | 22 | 0.0944206008583691 | 45 | 2 | 0.0085836909871244 | 0 |
| TNFRSF11A-202 | TNFRSF11A | Q9Y6Q6 | Tumor necrosis factor receptor superfamily member 11A | chr18 | GO:0051091 | Not Cancer Driver | No | 61 | 0.099025974025974 | 286 | 33 | 0.0535714285714285 | 5 |
| TNFSF11-202 | TNFSF11 | O14788 | Tumor necrosis factor ligand superfamily member 11 | chr13 | GO:0051091 | Not Cancer Driver | No | 32 | 0.1009463722397476 | 57 | 0 | 0.0 | 1 |
| TP53BP1-201 | TP53BP1 | Q12888 | TP53-binding protein 1 | chr15 | GO:0051091 | Not Cancer Driver | No | 159 | 0.0806288032454361 | 1638 | 131 | 0.0664300202839756 | 0 |
| TRAF2-201 | TRAF2 | Q12933 | TNF receptor-associated factor 2 | chr9 | GO:0051091 | Not Cancer Driver | No | 51 | 0.1017964071856287 | 4 | 1 | 0.0019960079840319 | 0 |
| TRAF5-201 | TRAF5 | O00463 | TNF receptor-associated factor 5 | chr1 | GO:0051091 | Not Cancer Driver | No | 46 | 0.0825852782764811 | 59 | 4 | 0.0071813285457809 | 0 |
| TRAF6-202 | TRAF6 | Q9Y4K3 | TNF receptor-associated factor 6 | chr11 | GO:0051091 | Not Cancer Driver | No | 51 | 0.0977011494252873 | 62 | 5 | 0.0095785440613026 | 0 |
| TRIM14-201 | TRIM14 | Q14142 | Tripartite motif-containing protein 14 | chr9 | GO:0051091 | Not Cancer Driver | No | 28 | 0.0633484162895927 | 94 | 4 | 0.0090497737556561 | 0 |
| TRIM15-206 | TRIM15 | Q9C019 | E3 ubiquitin-protein ligase TRIM15 | chr6 | GO:0051091 | Not Cancer Driver | No | 46 | 0.0989247311827957 | 79 | 7 | 0.0150537634408602 | 0 |
| TRIM21-201 | TRIM21 | P19474 | E3 ubiquitin-protein ligase TRIM21 | chr11 | GO:0051091 | Not Cancer Driver | No | 63 | 0.1326315789473684 | 49 | 8 | 0.0168421052631578 | 0 |
| TRIM22-201 | TRIM22 | Q8IYM9 | E3 ubiquitin-protein ligase TRIM22 | chr11 | GO:0051091 | Not Cancer Driver | No | 64 | 0.1285140562248996 | 27 | 0 | 0.0 | 0 |
| TRIM25-201 | TRIM25 | Q14258 | E3 ubiquitin/ISG15 ligase TRIM25 | chr17 | GO:0051091 | Not Cancer Driver | No | 45 | 0.0714285714285714 | 226 | 11 | 0.0174603174603174 | 0 |
| TRIM26-268 | TRIM26 | Q12899 | Tripartite motif-containing protein 26 | chr6 | GO:0051091 | Not Cancer Driver | No | 38 | 0.0705009276437847 | 153 | 5 | 0.0092764378478664 | 0 |
| TRIM27-202 | TRIM27 | P14373 | Zinc finger protein RFP | chr6 | GO:0051091 | Census | Yes | 46 | 0.0896686159844054 | 87 | 9 | 0.0175438596491228 | 0 |
| TRIM31-210 | TRIM31 | Q9BZY9 | E3 ubiquitin-protein ligase TRIM31 | chr6 | GO:0051091 | Not Cancer Driver | No | 37 | 0.0870588235294117 | 152 | 15 | 0.0352941176470588 | 0 |
| TRIM32-203 | TRIM32 | Q13049 | E3 ubiquitin-protein ligase TRIM32 | chr9 | GO:0051091 | Not Cancer Driver | No | 62 | 0.0949464012251148 | 87 | 9 | 0.0137825421133231 | 3 |
| TRIM34-201 | TRIM34 | Q9BYJ4 | E3 ubiquitin-protein ligase TRIM34 | chr11 | GO:0051091 | Not Cancer Driver | No | 55 | 0.1127049180327868 | 32 | 2 | 0.0040983606557377 | 0 |
| TRIM37-201 | TRIM37 | O94972 | E3 ubiquitin-protein ligase TRIM37 | chr17 | GO:0051091 | Not Cancer Driver | No | 89 | 0.0923236514522821 | 493 | 42 | 0.0435684647302904 | 3 |
| TRIM38-201 | TRIM38 | O00635 | E3 ubiquitin-protein ligase TRIM38 | chr6 | GO:0051091 | Not Cancer Driver | No | 46 | 0.0989247311827957 | 49 | 5 | 0.010752688172043 | 0 |
| TRIM5-202 | TRIM5 | Q9C035 | Tripartite motif-containing protein 5 | chr11 | GO:0051091 | Not Cancer Driver | No | 38 | 0.0770791075050709 | 78 | 7 | 0.0141987829614604 | 0 |
| TRIM62-201 | TRIM62 | Q9BVG3 | E3 ubiquitin-protein ligase TRIM62 | chr1 | GO:0051091 | Not Cancer Driver | No | 47 | 0.0989473684210526 | 81 | 12 | 0.0252631578947368 | 0 |
| TRIM8-209 | TRIM8 | Q9BZR9 | E3 ubiquitin-protein ligase TRIM8 | chr10 | GO:0051091 | Not Cancer Driver | No | 52 | 0.0943738656987295 | 209 | 23 | 0.0417422867513611 | 0 |
| WNT1-201 | WNT1 | P04628 | Proto-oncogene Wnt-1 | chr12 | GO:0051091 | Not Cancer Driver | No | 20 | 0.054054054054054 | 25 | 0 | 0.0 | 8 |
| WNT2-201 | WNT2 | P09544 | Protein Wnt-2 | chr7 | GO:0051091 | Not Cancer Driver | No | 53 | 0.1472222222222222 | 11 | 1 | 0.0027777777777777 | 0 |
| ZC4H2-202 | ZC4H2 | Q9NQZ6 | Zinc finger C4H2 domain-containing protein | chrX | GO:0051091 | Not Cancer Driver | No | 51 | 0.2276785714285714 | 136 | 34 | 0.1517857142857142 | 11 |
| ZIC2-201 | ZIC2 | O95409 | Zinc finger protein ZIC 2 | chr13 | GO:0051091 | Not Cancer Driver | No | 37 | 0.0695488721804511 | 388 | 20 | 0.037593984962406 | 18 |