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GRIK3-201 ,GRIK3 ,Q13003
  • Uniprot Accession= Q13003
  • Ensembl Transcript= ENST00000373091.8
  • Uniprot Name= GRIK3
  • Name= Glutamate receptor ionotropic, kainate 3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 27
GO term GO name GO namespace GO def
GO:0042391 regulation of membrane potential biological_process Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity molecular_function Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. [GOC:bf, GOC:dph]
GO:0004970 glutamate-gated receptor activity molecular_function Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [ISBN:0198506732]
GO:0008066 glutamate receptor activity molecular_function Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]
GO:0015277 kainate selective glutamate receptor activity molecular_function An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. [GOC:mah, PMID:10049997, PMID:8804111]
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential molecular_function Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:15145529, PMID:19558451]
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway biological_process An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
GO:0007215 glutamate receptor signaling pathway biological_process The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:9131252]
GO:0007216 G protein-coupled glutamate receptor signaling pathway biological_process A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling, PMID:9131252]
GO:0034220 monoatomic ion transmembrane transport biological_process A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]
GO:0035235 ionotropic glutamate receptor signaling pathway biological_process The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0198506732]
GO:0051967 negative regulation of synaptic transmission, glutamatergic biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
GO:0060078 regulation of postsynaptic membrane potential biological_process Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef]
GO:0099505 regulation of presynaptic membrane potential biological_process Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0030424 axon cellular_component The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
GO:0030425 dendrite cellular_component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
GO:0032839 dendrite cytoplasm cellular_component All of the contents of a dendrite, excluding the surrounding plasma membrane. [GOC:mah]
GO:0043195 terminal bouton cellular_component Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
GO:0043204 perikaryon cellular_component The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
GO:0098978 glutamatergic synapse cellular_component A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
GO:0032983 kainate selective glutamate receptor complex cellular_component An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits. [GOC:bf, http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html, PMID:18655795]
GO:0035249 synaptic transmission, glutamatergic biological_process The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos]
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential molecular_function Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, PMID:20200227]
GO:0098839 postsynaptic density membrane cellular_component The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]
GO:0042734 presynaptic membrane cellular_component A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
GO:0050804 modulation of chemical synaptic transmission biological_process Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]