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GTF2B-201 ,GTF2B ,Q00403
  • Uniprot Accession= Q00403
  • Ensembl Transcript= ENST00000370500.10
  • Uniprot Name= GTF2B
  • Name= Transcription initiation factor IIB
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 33
GO term GO name GO namespace GO def
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding molecular_function Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. [GOC:pg, GOC:txnOH, PMID:12381658]
GO:0000993 RNA polymerase II complex binding molecular_function Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH]
GO:0004402 histone acetyltransferase activity molecular_function Catalysis of the reaction
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008270 zinc ion binding molecular_function Binding to a zinc ion (Zn). [GOC:ai]
GO:0016251 RNA polymerase II general transcription initiation factor activity molecular_function A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]
GO:0016407 acetyltransferase activity molecular_function Catalysis of the transfer of an acetyl group to an acceptor molecule. [GOC:ai]
GO:0017025 TBP-class protein binding molecular_function Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]
GO:0046966 nuclear thyroid hormone receptor binding molecular_function Binding to a nuclear thyroid hormone receptor. [GOC:ai]
GO:0140297 DNA-binding transcription factor binding molecular_function Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]
GO:1990841 promoter-specific chromatin binding molecular_function Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]
GO:0001174 transcriptional start site selection at RNA polymerase II promoter biological_process Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH, PMID:16826228, PMID:18846104]
GO:0006338 chromatin remodeling biological_process A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
GO:0006366 transcription by RNA polymerase II biological_process The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
GO:0006367 transcription initiation at RNA polymerase II promoter biological_process A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. [GOC:mah, GOC:txnOH]
GO:0006473 protein acetylation biological_process The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
GO:0019083 viral transcription biological_process The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. [GOC:jl, ISBN:0781702534]
GO:0051123 RNA polymerase II preinitiation complex assembly biological_process The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym
GO:0051177 meiotic sister chromatid cohesion biological_process The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. [GOC:ai]
GO:0051225 spindle assembly biological_process The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
GO:1904798 positive regulation of core promoter binding biological_process Any process that activates or increases the frequency, rate or extent of core promoter binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
GO:1990114 RNA polymerase II core complex assembly biological_process The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex. [GOC:rb, PMID:23459708]
GO:0000776 kinetochore cellular_component A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:elh]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005694 chromosome cellular_component A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684]
GO:0016604 nuclear body cellular_component Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
GO:0032153 cell division site cellular_component The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]
GO:0042585 germinal vesicle cellular_component The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. [GOC:jl, GOC:mtg_sensu, PMID:19019837]
GO:0005669 transcription factor TFIID complex cellular_component A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
GO:0032993 protein-DNA complex cellular_component A macromolecular complex containing both protein and DNA molecules. [GOC:mah]
GO:0090575 RNA polymerase II transcription regulator complex cellular_component A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
GO:0097550 transcription preinitiation complex cellular_component A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. [GOC:di, PMID:22751016]