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HJV-201 ,HJV ,Q6ZVN8
  • Uniprot Accession= Q6ZVN8
  • Ensembl Transcript= ENST00000336751.11
  • Uniprot Name= HJV
  • Name= Hemojuvelin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 23
GO term GO name GO namespace GO def
GO:0060586 multicellular organismal-level iron ion homeostasis biological_process A chemical homeostatic process involved in the maintenance of a steady state level of iron within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. [PMID:31431773]
GO:0098821 BMP receptor activity molecular_function Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity. [GOC:BHF, GOC:dos]
GO:0005102 signaling receptor binding molecular_function Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0015026 coreceptor activity molecular_function Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]
GO:0036122 BMP binding molecular_function Binding to a member of the bone morphogenetic protein (BMP) family. [GOC:BHF, PMID:9660951]
GO:1990459 transferrin receptor binding molecular_function Binding to a transferrin receptor. [GOC:pm, PMID:9819414]
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0006366 transcription by RNA polymerase II biological_process The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
GO:0006879 intracellular iron ion homeostasis biological_process A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. [GOC:ai, GOC:mah]
GO:0016540 protein autoprocessing biological_process Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337]
GO:0030509 BMP signaling pathway biological_process The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0878932437, PMID:17428827]
GO:0030514 negative regulation of BMP signaling pathway biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. [GOC:go_curators]
GO:0032924 activin receptor signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:rl, GOC:signaling]
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
GO:0071773 cellular response to BMP stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. [GOC:mah, GOC:yaf]
GO:0005615 extracellular space cellular_component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0009986 cell surface cellular_component The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
GO:0098552 side of membrane cellular_component A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos]
GO:0070724 BMP receptor complex cellular_component A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits. [GOC:mah, GOC:mh, PMID:19377468]
GO:0098797 plasma membrane protein complex cellular_component Any protein complex that is part of the plasma membrane. [GOC:dos]
GO:1990712 HFE-transferrin receptor complex cellular_component A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. [GOC:BHF, GOC:kom, PMID:25147378]