| GO term | GO name | GO namespace | GO def |
| GO:0090575 | RNA polymerase II transcription regulator complex | cellular_component | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb] |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular_function | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| GO:0000993 | RNA polymerase II complex binding | molecular_function | Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH] |
| GO:0001097 | TFIIH-class transcription factor complex binding | molecular_function | Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867] |
| GO:0003677 | DNA binding | molecular_function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| GO:0003682 | chromatin binding | molecular_function | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130] |
| GO:0003690 | double-stranded DNA binding | molecular_function | Binding to double-stranded DNA. [GOC:elh, GOC:vw] |
| GO:0003697 | single-stranded DNA binding | molecular_function | Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174] |
| GO:0003714 | transcription corepressor activity | molecular_function | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867] |
| GO:0003723 | RNA binding | molecular_function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| GO:0003725 | double-stranded RNA binding | molecular_function | Binding to double-stranded RNA. [GOC:jl] |
| GO:0003727 | single-stranded RNA binding | molecular_function | Binding to single-stranded RNA. [GOC:jl] |
| GO:0003730 | mRNA 3'-UTR binding | molecular_function | Binding to a 3' untranslated region of an mRNA molecule. [GOC:mah] |
| GO:0003779 | actin binding | molecular_function | Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0008143 | poly(A) binding | molecular_function | Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. [GOC:jl] |
| GO:0017069 | snRNA binding | molecular_function | Binding to a small nuclear RNA (snRNA). [GOC:mah] |
| GO:0017130 | poly(C) RNA binding | molecular_function | Binding to a sequence of cytosine residues in an RNA molecule. [GOC:mah] |
| GO:0031490 | chromatin DNA binding | molecular_function | Binding to DNA that is assembled into chromatin. [GOC:mah] |
| GO:0034046 | poly(G) binding | molecular_function | Binding to a sequence of guanine residues in an RNA molecule. [GOC:mah] |
| GO:0036002 | pre-mRNA binding | molecular_function | Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120] |
| GO:0042802 | identical protein binding | molecular_function | Binding to an identical protein or proteins. [GOC:jl] |
| GO:0043021 | ribonucleoprotein complex binding | molecular_function | Binding to a complex of RNA and protein. [GOC:bf, GOC:go_curators, GOC:vk] |
| GO:0044877 | protein-containing complex binding | molecular_function | Binding to a macromolecular complex. [GOC:jl] |
| GO:0070034 | telomerase RNA binding | molecular_function | Binding to the telomerase RNA template. [GOC:krc, PMID:16884717] |
| GO:0099122 | RNA polymerase II C-terminal domain binding | molecular_function | Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. [PMID:20889714] |
| GO:0106222 | lncRNA binding | molecular_function | Binding to a long noncoding RNA (lncRNA). [PMID:25578728] |
| GO:1990837 | sequence-specific double-stranded DNA binding | molecular_function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
| GO:1990841 | promoter-specific chromatin binding | molecular_function | Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729] |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | biological_process | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. [GOC:krc] |
| GO:0000398 | mRNA splicing, via spliceosome | biological_process | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. [GOC:krc, ISBN:0198506732, ISBN:0879695897] |
| GO:0001649 | osteoblast differentiation | biological_process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid] |
| GO:0006325 | chromatin organization | biological_process | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130] |
| GO:0006396 | RNA processing | biological_process | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. [GOC:mah] |
| GO:0007049 | cell cycle | biological_process | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. [GOC:go_curators, GOC:mtg_cell_cycle] |
| GO:0007346 | regulation of mitotic cell cycle | biological_process | Any process that modulates the rate or extent of progress through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb] |
| GO:0009048 | dosage compensation by inactivation of X chromosome | biological_process | Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. [GOC:jl, GOC:mr, GOC:pr, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system] |
| GO:0032211 | negative regulation of telomere maintenance via telomerase | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah] |
| GO:0032922 | circadian regulation of gene expression | biological_process | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah] |
| GO:0033673 | negative regulation of kinase activity | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah] |
| GO:0034244 | negative regulation of transcription elongation by RNA polymerase II | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH] |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
| GO:0048255 | mRNA stabilization | biological_process | Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. [GOC:jid] |
| GO:0051301 | cell division | biological_process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| GO:0051457 | maintenance of protein location in nucleus | biological_process | Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. [GOC:ai] |
| GO:0055013 | cardiac muscle cell development | biological_process | The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. [GOC:devbiol, GOC:mtg_heart] |
| GO:0070934 | CRD-mediated mRNA stabilization | biological_process | An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). [GOC:mah, PMID:19029303] |
| GO:0071385 | cellular response to glucocorticoid stimulus | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:mah] |
| GO:0090336 | positive regulation of brown fat cell differentiation | biological_process | Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:BHF] |
| GO:0098963 | dendritic transport of messenger ribonucleoprotein complex | biological_process | The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites. [GOC:dos] |
| GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie] |
| GO:1901673 | regulation of mitotic spindle assembly | biological_process | Any process that modulates the frequency, rate or extent of mitotic spindle assembly. [GOC:TermGenie] |
| GO:1902275 | regulation of chromatin organization | biological_process | Any process that modulates the frequency, rate or extent of chromatin organization. [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] |
| GO:1902425 | positive regulation of attachment of mitotic spindle microtubules to kinetochore | biological_process | Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. [GOC:TermGenie, PMID:22065639] |
| GO:1902889 | protein localization to spindle microtubule | biological_process | A process in which a protein is transported to, or maintained in, a location within a spindle microtubule. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030] |
| GO:1990280 | RNA localization to chromatin | biological_process | A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. [GOC:dos, GOC:mah, PMID:22582262] |
| GO:1990830 | cellular response to leukemia inhibitory factor | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913] |
| GO:1990845 | adaptive thermogenesis | biological_process | The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. [PMID:17260010, PMID:20363363] |
| GO:2000373 | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity | biological_process | Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. [GOC:mah] |
| GO:2000648 | positive regulation of stem cell proliferation | biological_process | Any process that activates or increases the frequency, rate or extent of stem cell proliferation. [GOC:dph] |
| GO:2000737 | negative regulation of stem cell differentiation | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. [GOC:obol] |
| GO:2000767 | positive regulation of cytoplasmic translation | biological_process | Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. [GOC:obol] |
| GO:0000228 | nuclear chromosome | cellular_component | A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. [GOC:dph, GOC:mah] |
| GO:0000776 | kinetochore | cellular_component | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:elh] |
| GO:0000922 | spindle pole | cellular_component | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:clt] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0005813 | centrosome | cellular_component | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0009986 | cell surface | cellular_component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| GO:0016020 | membrane | cellular_component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| GO:0016363 | nuclear matrix | cellular_component | The dense fibrillar network lying on the inner side of the nuclear membrane. [ISBN:0582227089] |
| GO:0016607 | nuclear speck | cellular_component | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/] |
| GO:0030496 | midbody | cellular_component | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194] |
| GO:0032839 | dendrite cytoplasm | cellular_component | All of the contents of a dendrite, excluding the surrounding plasma membrane. [GOC:mah] |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | cellular_component | A ribonucleoprotein granule located in the cytoplasm. [GOC:bf, GOC:PARL, PMID:15121898] |
| GO:0070937 | CRD-mediated mRNA stability complex | cellular_component | A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. [GOC:mah, PMID:19029303] |
| GO:0072686 | mitotic spindle | cellular_component | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] |
| GO:0098577 | inactive sex chromosome | cellular_component | A sex chromosome that has been inactivated. [GOC:dos] |
| GO:1990023 | mitotic spindle midzone | cellular_component | The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. [GOC:mtg_cell_cycle, GOC:vw] |
| GO:1990498 | mitotic spindle microtubule | cellular_component | Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. [GOC:vw] |
| GO:0005697 | telomerase holoenzyme complex | cellular_component | Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. [PMID:11884619] |
| GO:0032991 | protein-containing complex | cellular_component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
| GO:0071013 | catalytic step 2 spliceosome | cellular_component | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] |
| GO:1990904 | ribonucleoprotein complex | cellular_component | A macromolecular complex that contains both RNA and protein molecules. [GOC:krc, GOC:vesicles] |
| GO:0000380 | alternative mRNA splicing, via spliceosome | biological_process | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. [GOC:krc, PMID:12110900] |