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INAVA-201 ,INAVA ,Q3KP66
  • Uniprot Accession= Q3KP66
  • Ensembl Transcript= ENST00000367342.8
  • Uniprot Name= INAVA
  • Name= Innate immunity activator protein
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 21
GO term GO name GO namespace GO def
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0002221 pattern recognition receptor signaling pathway biological_process The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
GO:0002720 positive regulation of cytokine production involved in immune response biological_process Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add]
GO:0031398 positive regulation of protein ubiquitination biological_process Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
GO:0032494 response to peptidoglycan biological_process Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:add, ISBN:0721601464]
GO:0032495 response to muramyl dipeptide biological_process Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. [GOC:add]
GO:0032731 positive regulation of interleukin-1 beta production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
GO:0032733 positive regulation of interleukin-10 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
GO:0032755 positive regulation of interleukin-6 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
GO:0032874 positive regulation of stress-activated MAPK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]
GO:0034334 adherens junction maintenance biological_process The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:mah]
GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
GO:0043410 positive regulation of MAPK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0060729 intestinal epithelial structure maintenance biological_process A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. [GOC:BHF, GOC:dph, GOC:tb]
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway biological_process The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]
GO:1903409 reactive oxygen species biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0016604 nuclear body cellular_component Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]