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IQGAP3-201 ,IQGAP3 ,Q86VI3
  • Uniprot Accession= Q86VI3
  • Ensembl Transcript= ENST00000361170.7
  • Uniprot Name= IQGAP3
  • Name= Ras GTPase-activating-like protein IQGAP3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 23
GO term GO name GO namespace GO def
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005516 calmodulin binding molecular_function Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
GO:0031267 small GTPase binding molecular_function Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
GO:0070856 myosin VI light chain binding molecular_function Binding to a light chain of a myosin VI complex. [GOC:sart]
GO:0000082 G1/S transition of mitotic cell cycle biological_process The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle]
GO:0001934 positive regulation of protein phosphorylation biological_process Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
GO:0007265 Ras protein signal transduction biological_process An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]
GO:0008361 regulation of cell size biological_process Any process that modulates the size of a cell. [GOC:go_curators]
GO:0010467 gene expression biological_process The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
GO:0010628 positive regulation of gene expression biological_process Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0010629 negative regulation of gene expression biological_process Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0033598 mammary gland epithelial cell proliferation biological_process The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:mah]
GO:0033601 positive regulation of mammary gland epithelial cell proliferation biological_process Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]
GO:0043410 positive regulation of MAPK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
GO:0070371 ERK1 and ERK2 cascade biological_process A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier
GO:0071310 cellular response to organic substance biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:mah]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005911 cell-cell junction cellular_component A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
GO:0016328 lateral plasma membrane cellular_component The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]
GO:0005938 cell cortex cellular_component The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]
GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization biological_process Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
GO:0005096 GTPase activator activity molecular_function Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]
GO:0051015 actin filament binding molecular_function Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]