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ISG15-203 ,ISG15 ,P05161
  • Uniprot Accession= P05161
  • Ensembl Transcript= ENST00000649529.1
  • Uniprot Name= ISG15
  • Name= Ubiquitin-like protein ISG15
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 29
GO term GO name GO namespace GO def
GO:0005178 integrin binding molecular_function Binding to an integrin. [GOC:ceb]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0031386 protein tag activity molecular_function A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]
GO:0007229 integrin-mediated signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
GO:0009615 response to virus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb]
GO:0030501 positive regulation of bone mineralization biological_process Any process that activates or increases the frequency, rate or extent of bone mineralization. [GOC:go_curators]
GO:0031397 negative regulation of protein ubiquitination biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
GO:0032020 ISG15-protein conjugation biological_process The covalent addition to a protein of ISG15, a ubiquitin-like protein. [GOC:mah]
GO:0032461 positive regulation of protein oligomerization biological_process Any process that activates or increases the frequency, rate or extent of protein oligomerization. [GOC:mah]
GO:0032649 regulation of type II interferon production biological_process Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
GO:0032728 positive regulation of interferon-beta production biological_process Any process that activates or increases the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]
GO:0032729 positive regulation of type II interferon production biological_process Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
GO:0032733 positive regulation of interleukin-10 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
GO:0034340 response to type I interferon biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
GO:0042742 defense response to bacterium biological_process Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
GO:0045071 negative regulation of viral genome replication biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. [GOC:go_curators]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0045648 positive regulation of erythrocyte differentiation biological_process Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]
GO:0051607 defense response to virus biological_process Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
GO:0060339 negative regulation of type I interferon-mediated signaling pathway biological_process Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]
GO:0070585 protein localization to mitochondrion biological_process A process in which a protein is transported to, or maintained in, a location within the mitochondrion. [GOC:ecd]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005576 extracellular region cellular_component The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0031625 ubiquitin protein ligase binding molecular_function Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
GO:0016567 protein ubiquitination biological_process The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
GO:0019941 modification-dependent protein catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. [GOC:go_curators]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]