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KCNA2-201 ,KCNA2 ,P16389
  • Uniprot Accession= P16389
  • Ensembl Transcript= ENST00000316361.10
  • Uniprot Name= KCNA2
  • Name= Potassium voltage-gated channel subfamily A member 2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 38
GO term GO name GO namespace GO def
GO:0005249 voltage-gated potassium channel activity molecular_function Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]
GO:0005251 delayed rectifier potassium channel activity molecular_function Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513]
GO:0005267 potassium channel activity molecular_function Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0015271 outward rectifier potassium channel activity molecular_function Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]
GO:0019894 kinesin binding molecular_function Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]
GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential molecular_function Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. [GOC:dos]
GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential molecular_function Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005]
GO:0006813 potassium ion transport biological_process The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
GO:0014059 regulation of dopamine secretion biological_process Any process that modulates the frequency, rate or extent of the regulated release of dopamine. [GOC:ef]
GO:0019228 neuronal action potential biological_process An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb]
GO:0019233 sensory perception of pain biological_process The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]
GO:0021633 optic nerve structural organization biological_process The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
GO:0021987 cerebral cortex development biological_process The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
GO:0022038 corpus callosum development biological_process The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep biological_process Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. [GOC:go_curators]
GO:0051260 protein homooligomerization biological_process The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]
GO:0060078 regulation of postsynaptic membrane potential biological_process Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef]
GO:0071805 potassium ion transmembrane transport biological_process A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
GO:0097623 potassium ion export across plasma membrane biological_process The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440]
GO:0099505 regulation of presynaptic membrane potential biological_process Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef]
GO:0005789 endoplasmic reticulum membrane cellular_component The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0030027 lamellipodium cellular_component A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]
GO:0030424 axon cellular_component The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
GO:0030425 dendrite cellular_component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
GO:0031258 lamellipodium membrane cellular_component The portion of the plasma membrane surrounding a lamellipodium. [GOC:mah]
GO:0032809 neuronal cell body membrane cellular_component The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. [GOC:jl]
GO:0033010 paranodal junction cellular_component A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. [PMID:11395001, PMID:14630217]
GO:0042734 presynaptic membrane cellular_component A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
GO:0043194 axon initial segment cellular_component Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]
GO:0043204 perikaryon cellular_component The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
GO:0043679 axon terminus cellular_component Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl]
GO:0044224 juxtaparanode region of axon cellular_component A region of an axon near a node of Ranvier that is between the paranode and internode regions. [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]
GO:0044305 calyx of Held cellular_component The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]
GO:0045211 postsynaptic membrane cellular_component A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]
GO:0098978 glutamatergic synapse cellular_component A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
GO:0008076 voltage-gated potassium channel complex cellular_component A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]