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LAMTOR2-203 ,LAMTOR2 ,Q9Y2Q5
  • Uniprot Accession= Q9Y2Q5
  • Ensembl Transcript= ENST00000368305.9
  • Uniprot Name= LAMTOR2
  • Name= Ragulator complex protein LAMTOR2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 22
GO term GO name GO namespace GO def
GO:0150116 regulation of cell-substrate junction organization biological_process Any process that modulates the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GO:0060090 molecular adaptor activity molecular_function The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0001558 regulation of cell growth biological_process Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
GO:0008104 protein localization biological_process Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]
GO:0010761 fibroblast migration biological_process Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:BHF, GOC:dph, GOC:tb]
GO:0032008 positive regulation of TOR signaling biological_process Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]
GO:0038202 TORC1 signaling biological_process A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]
GO:0043410 positive regulation of MAPK cascade biological_process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
GO:0071230 cellular response to amino acid stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah]
GO:1902414 protein localization to cell junction biological_process A process in which a protein is transported to, or maintained in, a location within a cell junction. [GOC:TermGenie, PMID:18332111]
GO:1904263 positive regulation of TORC1 signaling biological_process Any process that activates or increases the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
GO:0005765 lysosomal membrane cellular_component The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
GO:0005770 late endosome cellular_component A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0010008 endosome membrane cellular_component The lipid bilayer surrounding an endosome. [GOC:mah]
GO:0031902 late endosome membrane cellular_component The lipid bilayer surrounding a late endosome. [GOC:pz]
GO:0035579 specific granule membrane cellular_component The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
GO:0070821 tertiary granule membrane cellular_component The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
GO:0071986 Ragulator complex cellular_component A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]
GO:1990877 FNIP-folliculin RagC/D GAP cellular_component A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2. [GOC:rn, PMID:24095279, PMID:26387955, PMID:34805795]