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LAMTOR5-206 ,LAMTOR5 ,O43504
  • Uniprot Accession= O43504
  • Ensembl Transcript= ENST00000602318.6
  • Uniprot Name= LAMTOR5
  • Name= Ragulator complex protein LAMTOR5
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 25
GO term GO name GO namespace GO def
GO:0010628 positive regulation of gene expression biological_process Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:1905636 positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding biological_process Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23675531]
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GO:0060090 molecular adaptor activity molecular_function The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008361 regulation of cell size biological_process Any process that modulates the size of a cell. [GOC:go_curators]
GO:0009615 response to virus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb]
GO:0019079 viral genome replication biological_process Any process involved directly in viral genome replication, including viral nucleotide metabolism. [ISBN:0781702534]
GO:0032008 positive regulation of TOR signaling biological_process Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]
GO:0032757 positive regulation of interleukin-8 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
GO:0038202 TORC1 signaling biological_process A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]
GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0061462 protein localization to lysosome biological_process A process in which a protein is transported to, or maintained in, a location within a lysosome. [GOC:dph]
GO:0071230 cellular response to amino acid stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah]
GO:1900182 positive regulation of protein localization to nucleus biological_process Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]
GO:1904263 positive regulation of TORC1 signaling biological_process Any process that activates or increases the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
GO:0005765 lysosomal membrane cellular_component The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
GO:0005764 lysosome cellular_component A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0031902 late endosome membrane cellular_component The lipid bilayer surrounding a late endosome. [GOC:pz]
GO:0071986 Ragulator complex cellular_component A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
GO:1990877 FNIP-folliculin RagC/D GAP cellular_component A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2. [GOC:rn, PMID:24095279, PMID:26387955, PMID:34805795]