| GO term | GO name | GO namespace | GO def |
| GO:0001540 | amyloid-beta binding | molecular_function | Binding to an amyloid-beta peptide/protein. [GOC:hjd] |
| GO:0001784 | phosphotyrosine residue binding | molecular_function | Binding to a phosphorylated tyrosine residue within a protein. [PMID:14636584] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | molecular_function | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. [GOC:bf, GOC:jl] |
| GO:0030159 | signaling receptor complex adaptor activity | molecular_function | The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. [GOC:mah] |
| GO:0030276 | clathrin binding | molecular_function | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. [GOC:jl, GOC:mah, ISBN:0198506732] |
| GO:0035591 | signaling adaptor activity | molecular_function | The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. [GOC:bf, PMID:19104498] |
| GO:0035612 | AP-2 adaptor complex binding | molecular_function | Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499] |
| GO:0035615 | clathrin adaptor activity | molecular_function | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. [GOC:BHF, PMID:15728179] |
| GO:0035650 | AP-1 adaptor complex binding | molecular_function | Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). [PMID:21097499] |
| GO:0050750 | low-density lipoprotein particle receptor binding | molecular_function | Binding to a low-density lipoprotein receptor. [GOC:ai] |
| GO:0006898 | receptor-mediated endocytosis | biological_process | An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363] |
| GO:0008203 | cholesterol metabolic process | biological_process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732] |
| GO:0030301 | cholesterol transport | biological_process | The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, ISBN:0198506732] |
| GO:0031623 | receptor internalization | biological_process | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] |
| GO:0034383 | low-density lipoprotein particle clearance | biological_process | The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah] |
| GO:0042632 | cholesterol homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| GO:0042982 | amyloid precursor protein metabolic process | biological_process | The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators] |
| GO:0043393 | regulation of protein binding | biological_process | Any process that modulates the frequency, rate or extent of protein binding. [GOC:go_curators] |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | biological_process | Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb] |
| GO:0071345 | cellular response to cytokine stimulus | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:mah] |
| GO:0090118 | receptor-mediated endocytosis involved in cholesterol transport | biological_process | A receptor-mediated endocytosis process involved in intracellular cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:pr, GOC:tb] |
| GO:0090205 | positive regulation of cholesterol metabolic process | biological_process | Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb] |
| GO:1903076 | regulation of protein localization to plasma membrane | biological_process | Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] |
| GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | biological_process | Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467] |
| GO:1905581 | positive regulation of low-density lipoprotein particle clearance | biological_process | Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] |
| GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport | biological_process | Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] |
| GO:0005769 | early endosome | cellular_component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0005883 | neurofilament | cellular_component | A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0009898 | cytoplasmic side of plasma membrane | cellular_component | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| GO:0009925 | basal plasma membrane | cellular_component | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| GO:0030424 | axon | cellular_component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | cellular_component | The lipid bilayer surrounding a clathrin-coated endocytic vesicle. [GOC:mah] |
| GO:0055037 | recycling endosome | cellular_component | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] |