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LGR6-203 ,LGR6 ,Q9HBX8
  • Uniprot Accession= Q9HBX8
  • Ensembl Transcript= ENST00000367278.8
  • Uniprot Name= LGR6
  • Name= Leucine-rich repeat-containing G-protein coupled receptor 6
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 18
GO term GO name GO namespace GO def
GO:0004930 G protein-coupled receptor activity molecular_function Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
GO:0004888 transmembrane signaling receptor activity molecular_function Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0016500 protein-hormone receptor activity molecular_function Combining with a protein hormone to initiate a change in cell activity. [GOC:mah]
GO:0007186 G protein-coupled receptor signaling pathway biological_process The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
GO:0008283 cell population proliferation biological_process The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
GO:0016055 Wnt signaling pathway biological_process The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]
GO:0030177 positive regulation of Wnt signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. [GOC:dph, GOC:go_curators, GOC:tb]
GO:0030335 positive regulation of cell migration biological_process Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
GO:0090263 positive regulation of canonical Wnt signaling pathway biological_process Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]
GO:1990523 bone regeneration biological_process The regrowth of bone following its loss or destruction. [PMID:25257467]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0031982 vesicle cellular_component Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
GO:0032588 trans-Golgi network membrane cellular_component The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. [GOC:mah]
GO:0008201 heparin binding molecular_function Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]
GO:0050919 negative chemotaxis biological_process The directed movement of a motile cell or organism towards a lower concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]
GO:0007411 axon guidance biological_process The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
GO:0048495 Roundabout binding molecular_function Binding to Roundabout (ROBO) receptor, a transmembrane receptor. [GOC:ecd, PMID:10102268, PMID:10197527]