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MSH4-201 ,MSH4 ,O15457
  • Uniprot Accession= O15457
  • Ensembl Transcript= ENST00000263187.4
  • Uniprot Name= MSH4
  • Name= MutS protein homolog 4
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 16
GO term GO name GO namespace GO def
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005524 ATP binding molecular_function Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GO:0030983 mismatched DNA binding molecular_function Binding to a double-stranded DNA region containing one or more mismatches. [GOC:mah]
GO:0140664 ATP-dependent DNA damage sensor activity molecular_function A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. [PMID:33302090, PMID:33510387]
GO:0001541 ovarian follicle development biological_process The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
GO:0006298 mismatch repair biological_process A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. [ISBN:0198506732, PMID:11687886]
GO:0007129 homologous chromosome pairing at meiosis biological_process The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]
GO:0007283 spermatogenesis biological_process The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
GO:0007292 female gamete generation biological_process Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. [GOC:dph, ISBN:0198506732]
GO:0000795 synaptonemal complex cellular_component A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element. [DOI:10.5772/29752, GOC:elh]
GO:0005694 chromosome cellular_component A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684]
GO:0005713 recombination nodule cellular_component An electron dense structure that is associated with meiotic chromosomes. [GOC:elh]
GO:0003690 double-stranded DNA binding molecular_function Binding to double-stranded DNA. [GOC:elh, GOC:vw]
GO:0007131 reciprocal meiotic recombination biological_process The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. [PMID:2087779]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]