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MTHFR-204 ,MTHFR ,P42898
  • Uniprot Accession= P42898
  • Ensembl Transcript= ENST00000376590.9
  • Uniprot Name= MTHFR
  • Name= Methylenetetrahydrofolate reductase (NADPH)
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 21
GO term GO name GO namespace GO def
GO:0001843 neural tube closure biological_process The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. [GOC:dph, ISBN:0878932437]
GO:0070828 heterochromatin organization biological_process Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. [GOC:mah]
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function Catalysis of the reaction
GO:0044877 protein-containing complex binding molecular_function Binding to a macromolecular complex. [GOC:jl]
GO:0050660 flavin adenine dinucleotide binding molecular_function Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]
GO:0050661 NADP binding molecular_function Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]
GO:0072341 modified amino acid binding molecular_function Binding to a modified amino acid. [GOC:mah]
GO:0106313 methylenetetrahydrofolate reductase NADPH activity molecular_function Catalysis of the reaction
GO:0001666 response to hypoxia biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
GO:0006555 methionine metabolic process biological_process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]
GO:0009410 response to xenobiotic stimulus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
GO:0033274 response to vitamin B2 biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus. [GOC:sl]
GO:0035999 tetrahydrofolate interconversion biological_process The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. [GOC:yaf, PMID:1825999]
GO:0043200 response to amino acid biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:ef, GOC:mlg]
GO:0046500 S-adenosylmethionine metabolic process biological_process The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:go_curators, ISBN:0198506732]
GO:0050667 homocysteine metabolic process biological_process The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. [ISBN:0198506732]
GO:0051593 response to folic acid biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. [GOC:ai]
GO:0070555 response to interleukin-1 biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:BHF, GOC:mah]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0071949 FAD binding molecular_function Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]
GO:0009086 methionine biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]