| GO term | GO name | GO namespace | GO def |
| GO:0032405 | MutLalpha complex binding | molecular_function | Binding to a MutLalpha mismatch repair complex. [GOC:vk] |
| GO:0032406 | MutLbeta complex binding | molecular_function | Binding to a MutLbeta mismatch repair complex. [GOC:vk] |
| GO:0032408 | MutSbeta complex binding | molecular_function | Binding to a MutSbeta mismatch repair complex. [GOC:vk] |
| GO:0000701 | purine-specific mismatch base pair DNA N-glycosylase activity | molecular_function | Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. [GOC:elh, PMID:9224623] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0019104 | DNA N-glycosylase activity | molecular_function | Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:11554296] |
| GO:0032407 | MutSalpha complex binding | molecular_function | Binding to a MutSalpha mismatch repair complex. [GOC:vk] |
| GO:0046872 | metal ion binding | molecular_function | Binding to a metal ion. [GOC:ai] |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | molecular_function | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] |
| GO:0006281 | DNA repair | biological_process | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486] |
| GO:0045007 | depurination | biological_process | The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar. [GOC:ai] |
| GO:0060546 | negative regulation of necroptotic process | biological_process | Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0005739 | mitochondrion | cellular_component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| GO:0006298 | mismatch repair | biological_process | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. [ISBN:0198506732, PMID:11687886] |
| GO:0035485 | adenine/guanine mispair binding | molecular_function | Binding to a double-stranded DNA region containing an A/G mispair. [GOC:bf, GOC:jh] |
| GO:0034039 | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | molecular_function | Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. [GOC:mah, PMID:17641464] |
| GO:0006284 | base-excision repair | biological_process | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194] |
| GO:0032357 | oxidized purine DNA binding | molecular_function | Binding to a DNA region containing an oxidized purine residue. [GOC:vk] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |