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NBL1-202 ,NBL1 ,P41271
  • Uniprot Accession= P41271
  • Ensembl Transcript= ENST00000375136.8
  • Uniprot Name= NBL1
  • Name= Neuroblastoma suppressor of tumorigenicity 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 16
GO term GO name GO namespace GO def
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0016015 morphogen activity molecular_function Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. [GOC:go_curators]
GO:0036122 BMP binding molecular_function Binding to a member of the bone morphogenetic protein (BMP) family. [GOC:BHF, PMID:9660951]
GO:0042802 identical protein binding molecular_function Binding to an identical protein or proteins. [GOC:jl]
GO:0007165 signal transduction biological_process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
GO:0007399 nervous system development biological_process The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
GO:0030514 negative regulation of BMP signaling pathway biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. [GOC:go_curators]
GO:0035582 sequestering of BMP in extracellular matrix biological_process Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. [GOC:BHF, PMID:20855508]
GO:0038098 sequestering of BMP from receptor via BMP binding biological_process Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor. [GOC:bf, GOC:signaling, PMID:19855014]
GO:0045666 positive regulation of neuron differentiation biological_process Any process that activates or increases the frequency, rate or extent of neuron differentiation. [GOC:go_curators]
GO:0048263 determination of dorsal identity biological_process Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:jid]
GO:0048812 neuron projection morphogenesis biological_process The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. [GOC:mah]
GO:0090027 negative regulation of monocyte chemotaxis biological_process Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]
GO:0005615 extracellular space cellular_component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
GO:0009887 animal organ morphogenesis biological_process Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
GO:0048018 receptor ligand activity molecular_function The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]