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NDUFS2-224 ,NDUFS2 ,O75306
  • Uniprot Accession= O75306
  • Ensembl Transcript= ENST00000676972.1
  • Uniprot Name= NDUFS2
  • Name= NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 25
GO term GO name GO namespace GO def
GO:0003954 NADH dehydrogenase activity molecular_function Catalysis of the reaction
GO:0008137 NADH dehydrogenase (ubiquinone) activity molecular_function Catalysis of the reaction
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0009055 electron transfer activity molecular_function A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer]
GO:0019826 oxygen sensor activity molecular_function Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]
GO:0031625 ubiquitin protein ligase binding molecular_function Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0048038 quinone binding molecular_function Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732]
GO:0051287 NAD binding molecular_function Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]
GO:0051539 4 iron, 4 sulfur cluster binding molecular_function Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
GO:0006120 mitochondrial electron transport, NADH to ubiquinone biological_process The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363]
GO:0006979 response to oxidative stress biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
GO:0009060 aerobic respiration biological_process The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]
GO:0022008 neurogenesis biological_process Generation of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
GO:0032981 mitochondrial respiratory chain complex I assembly biological_process The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. [GOC:rph]
GO:0042063 gliogenesis biological_process The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. [GOC:dgh, GOC:jid]
GO:0042775 mitochondrial ATP synthesis coupled electron transport biological_process The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. [GOC:mtg_sensu, ISBN:0716731363]
GO:0042776 proton motive force-driven mitochondrial ATP synthesis biological_process The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363]
GO:0061351 neural precursor cell proliferation biological_process The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. [GOC:dph, GOC:yaf]
GO:0071453 cellular response to oxygen levels biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:mah]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005739 mitochondrion cellular_component A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
GO:0005743 mitochondrial inner membrane cellular_component The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
GO:0005747 mitochondrial respiratory chain complex I cellular_component A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. [GOC:mtg_sensu, ISBN:0198547684]
GO:0005759 mitochondrial matrix cellular_component The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]