| GO term | GO name | GO namespace | GO def |
| GO:0062023 | collagen-containing extracellular matrix | cellular_component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
| GO:0005201 | extracellular matrix structural constituent | molecular_function | The action of a molecule that contributes to the structural integrity of the extracellular matrix. [GOC:mah] |
| GO:0005509 | calcium ion binding | molecular_function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| GO:0005518 | collagen binding | molecular_function | Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732] |
| GO:0043236 | laminin binding | molecular_function | Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. [GOC:ecd] |
| GO:0043237 | laminin-1 binding | molecular_function | Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. [GOC:go_curators] |
| GO:0043394 | proteoglycan binding | molecular_function | Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [ISBN:0198506732] |
| GO:0007160 | cell-matrix adhesion | biological_process | The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb] |
| GO:0010811 | positive regulation of cell-substrate adhesion | biological_process | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb] |
| GO:0032836 | glomerular basement membrane development | biological_process | The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. [GOC:sr] |
| GO:0045785 | positive regulation of cell adhesion | biological_process | Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators] |
| GO:0051149 | positive regulation of muscle cell differentiation | biological_process | Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai] |
| GO:0071711 | basement membrane organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. [GOC:mah] |
| GO:0110011 | regulation of basement membrane organization | biological_process | Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. [GOC:ha, PMID:27404358] |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway | biological_process | Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol] |
| GO:0005576 | extracellular region | cellular_component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| GO:0005604 | basement membrane | cellular_component | A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. [ISBN:0198547684, PMID:22505934] |
| GO:0070062 | extracellular exosome | cellular_component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| GO:0098637 | protein complex involved in cell-matrix adhesion | cellular_component | Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion. [GOC:dos] |
| GO:0042813 | Wnt receptor activity | molecular_function | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:go_curators] |
| GO:0060070 | canonical Wnt signaling pathway | biological_process | A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488] |
| GO:0017147 | Wnt-protein binding | molecular_function | Binding to a Wnt-protein, a secreted growth factor involved in signaling. [GOC:jl] |